Heterocyclic Building Block-benzofuran

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, belongs to benzofurans compound. In a document, author is Ryabukhin, Dmitry S., introduce the new discover.

One-pot propargylation and Claisen-type rearrangement for natural lignans matairesinol and alpha-conidendrin

Improved methods for one-pot propargylation and Claisen rearrangement have been devised for natural lignans – matairesinol and alpha-conidendrin. The rearrangement was regiospecific, yielding only 2-methylbenzofuran derivatives.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3. Name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3, belongs to benzofurans compound. In a document, author is Rubab, Momna, introduce the new discover, Application In Synthesis of Ethyl 5-aminobenzofuran-2-carboxylate.

Bioactive Potential of 2-Methoxy-4-vinylphenol and Benzofuran from Brassica oleracea L. var. capitate f, rubra (Red Cabbage) on Oxidative and Microbiological Stability of Beef Meat

In the future, plant based phytochemicals will be considered as efficient replacement sources of chemical preservatives, to act as potential bio-preservatives. We investigated the antibacterial and antioxidant activity of red cabbage (RC) extracts using different solvents. Among all extracts, chloroform extract exhibited strong antimicrobial and antioxidant activities. Hence, the phytochemical constitutions of the RC chloroform extract was examined by GC-MS analysis, and further, based on molecular docking analysis, revealed 2-Methoxy-4-vinylphenol and benzofuran as two major compounds found to be possessing higher degrees of interaction with DNA gyrase (4PLB; -8.63 Kcal.mol(-1)) and lipoprotein (LpxC-8.229 Kcal.mol(-1)), respectively, of the bacterial cell wall, which leads to higher antimicrobial efficacy. Further, it was confirmed with that the in vivoCaenorhabditis elegansmodel (but no cytotoxic effect) was exhibited in the MCF-7 cell line. Thus, we investigated the influence of this extract on the shelf life of meat under refrigeration storage. The physicochemical properties were observed periodically, and microbial analysis was conducted. The shelf life of the beef was enhanced (up to eight days) in terms of microbial and physiochemical properties, at 4 +/- 2 degrees C when compared to control. We concluded that chloroform extract of RC has potential as a natural preservative in the meat processing industry.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 174775-48-5. Application In Synthesis of Ethyl 5-aminobenzofuran-2-carboxylate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, formurla is C11H11NO3. In a document, author is Yamaguchi, Yuki, introducing its new discovery. Computed Properties of C11H11NO3.

Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

If you are hungry for even more, make sure to check my other article about 174775-48-5, Computed Properties of C11H11NO3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 497-23-4497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Caliskan, Zerrin Zerenler, introduce new discover of the category.

Synthesis of New 4-Oxo-Tetrahydroindol Derivatives by Using Chemical and Microbial Biotransformation Methods

An efficient method for the preparation of 4-oxo-4,5,6,7-tetrahydroindoles was successfully applied to the synthesis of N-substituted 4-oxo-4,5,6,7-tetrahydroindoles (4) and (5) for the first time. Manganese(III) acetate-mediated acetoxylation of (2) produced 4,5,6,7-tetrahydro-4-oxo-7,7-dimethyl benzofuran-5-yl acetate (3) for the first time in the literature. Then 4,5,6,7-tetrahydro-4-oxo-7,7-dimethyl benzofuran-5-yl acetate was converted to its indole derivative (4) via benzyl amine. Thus, 1-benzyl-5-hydroxy-7,7-dimethyl-6,7-dihydro-1H-indol-4(5H)-one (4) was obtained in good yields. Furthermore, biotransformation of pharmacologically interesting compounds such as 5-hydroxy-7,7-dimethyl-6,7-dihydro-1H-indol-4-(5H)-one (5) were also obtained by biotransformation reaction using Aspergillus niger.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 497-23-4. Recommanded Product: 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 97148-39-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, SMILES is O=C([O-])/C(C1=CC=CO1)=NOC.[NH4+], belongs to benzofurans compound. In a article, author is Mokhtar, Mohamed, introduce new discover of the category.

A Green Mechanochemical One-Pot Three-Component Domino Reaction Synthesis of Polysubstituted Azoloazines Containing Benzofuran Moiety: Cytotoxic Activity Against HePG2 Cell Lines

A one-pot procedure for the synthesis of azolopyrimidine derivatives by a three-component reaction of beta-ketosulfone, aldehyde, and 2-aminoben-zimidazole over synthetic magadiite clay (SMC-H) under ball milling in the absence of any solvent and additive has been developed. The catalyst was re-used for consequent reactions. The novel manufactured compounds were verified for HePG2 cell development inhibition. A pronounced inhibitory effect on the growth of HePG2 cell line was recorded. This protocol offers a broad scope for an access to a variety of diversely substituted azolopyrimidines of high inhibition activity against HePG2 cell line. The use of non-hazardous organic solvent, ball milling, cost efficiency, recyclability of the catalyst up to six runs without appreciable loss of activity, and high yields of products make this procedure greener.

Related Products of 97148-39-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 97148-39-5.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Synthetic Route of 6296-53-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a article, author is Chen, Hui, introduce new discover of the category.

Site-selective remote C(sp(3))-H heteroarylation of amides via organic photoredox catalysis

Radical translocation processes triggered by nitrogen-centered radicals (NCRs), such as 1,5-hydrogen atom transfers (1,5-HAT), demonstrated by the well-established Hofmann-Loffler-Freytag (HLF) reaction, provide an attractive approach for the controllable and selective functionalization of remote inert C(sp(3))-H bonds. Here we report an amidyl radical-triggered site-selective remote C(sp(3))-H heteroarylation of amides under organic photoredox conditions. This approach provides a mild and highly regioselective reaction affording remote C(sp(3))-H heteroarylated amides at room temperature under transition-metal free, weakly basic, and redox-neutral conditions. Non-prefunctionalized heteroarenes, such as purines, thiazolopyridines, benzoxazole, benzothiazoles, benzothiophene, benzofuran, thiazoles and quinoxalines, can be alkylated directly. Sequential and orthogonal C-H functionalization of different heteroarenes by taking advantage pH value or polarity of radicals has also been achieved. DFT calculations explain and can predict the site-selectivity and reactivity of this reaction. This strategy expands the scope of the Minisci reaction and serves as its alternative and potential complement.

Synthetic Route of 6296-53-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 6296-53-3 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is van Rensburg, Helena D. Janse, once mentioned the new application about 591-11-7, Category: benzofurans.

Synthesis and evaluation of methoxy substituted 2-benzoyl-1-benzofuran derivatives as lead compounds for the development adenosine A(l) and/or A(2A) receptor antagonists

A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A(1) and A(2A) receptors via radioligand binding assays to establish the structure activity relationships pertinent for A(1) and A(2A) affinity. Compound 3j (6,7-dimethoxybenzofuran-2-yl)(3-methoxyphenyl) methanone exhibited A(1) affinity (A(1)K(i) (rat) = 6.880 mu M) as well as A(2A) affinity (A(2A)K(i) (rat) = 0.5161 mu M). Compounds 3a-b & 3i-k exhibited selective affinity towards A(1) with K-i values below 10 mu M. The results indicate that C6,7-diOCH(3) substitution on ring A in combination with meta (C3′)-OCH3 substitution on ring B is beneficial for A(1) and A(2A )affinity and activity. Compounds 3a-b & 3j-k showed low cytotoxicity. Upon in vitro and in silico evaluation, compound 3j may be considered lead-like (i.e. a molecular entity suitable for optimization) and, thus, of value in the design of novel, potent and selective adenosine A(1) and A(2A) receptor antagonists.

If you¡¯re interested in learning more about 591-11-7. The above is the message from the blog manager. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Li, Xiaohui, introduce the new discover, Category: benzofurans.

Expanded benzofuran-decorated twistacene derivatives: synthesis, characterization and single-component white electroluminescence

Two novel phenanthro[9,10-b]benzofuran and pyreno[4,5-b]benzofuran modified twistacene derivatives, 9 and 10, have been successfully synthesized via Suzuki coupling and then characterized. The photophysical properties were examined and DFT calculations were carried out in a comparative manner, and both molecules emitted strong blue light in organic solvents and in the solid state. Impressively, fabricated electroluminescent devices based on these single emitters radiate pure white light.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6296-53-3 is helpful to your research. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a document, author is Ganea, Iolanda-Veronica, introduce the new discover, Product Details of 66357-35-5.

Study of Metal Ion Removal from Aqueous Systems Using Magnetic Nanostructures Based on Functionalized Poly(Benzofuran-co-Arylacetic Acid)

Metal pollution has become a worldwide problem, mainly because of the toxicity, effects on living organisms, and the impact on the food chain and the quality of drinking water. Researchers have been focusing on developing new materials through green chemistry methods in order to remove these pollutants from the environment. In the recent decades, due to their unique properties, magnetic nanostructures containing functionalized polymers as shells have been demonstrated to be useful in water and wastewater treatment for this application. In this study, we report the synthesis and characterization of hybrid magnetic core-shell nanostructures including magnetite as the inorganic core and poly(benzofuran-co-arylacetic acid) functionalized with N alpha, N alpha’-bis(carboxymethyl)-L-lysine as the organic shell. These nanomaterials were used in the adsorption of different metal ions from aqueous solutions and contaminated water samples collected from Rosia River (Rosia Montana, Romania), representing attractive alternatives for water and/or wastewater treatment. The properties of the magnetic hybrid nanostructures were investigated by Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), magnetization measurements. The heavy metal concentrations in aqueous solutions were determined by flame atomic absorption spectrometry (FAAS).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 66357-35-5 is helpful to your research. Product Details of 66357-35-5.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 497-23-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Rao, Bodapati V. D., introduce new discover of the category.

Ultrasound Assisted Synthesis of 2-Substituted Benzofurans via One-Pot and Sequential Method: Their In Vitro Evaluation

Background: The 2-substituted benzofuran framework has attracted enormous attention due to its presence in a range of bioactive compounds and natural products. While various methods for the synthesis of 2-substituted benzofuran derivatives are known, several of them suffer from certain drawbacks. Objective: The main objective of this work was to explore a series of 2-(het)aryl substituted benzofurans derivatives for their cytotoxic properties against cancer cell lines in vitro. Methods: In our efforts, we have developed a one-pot synthesis of this class of compounds via sequential C-C coupling followed by C-Si bond cleavage and subsequent tandem C-C/C-O bond-forming reaction under ultrasound irradiation. The methodology involved coupling of (trimethylsilyl)acetylene with iodoarenes in the presence of 10% Pd/C-Cul-PPh3-Et3N in MeOH followed by treating the reaction mixture with K2CO3 in aqueous WON and finally coupling with 2-iodophenol. A variety of 2-substituted benzofurans were synthesized using this methodology in good yield. All the synthesized compounds were tested in vitro against two cancer cell lines, e.g. MDAMB-231 and MCF-7 cell lines subsequently against SIRT1. Results: The benzofuran derivative 3m showed encouraging growth inhibition of both MDAMB-231 and MCF-7 cell lines and significant inhibition of SIRT1. The compound 3m also showed a concentration-dependent increase in the acetylation of p53. Conclusion: Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans but also revealed that the benzofuran framework presented here could be a potential template for the identification of potent inhibitors of SIRT1.

Reference of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem