Interesting scientific research on 5-Methylfuran-2(5H)-one

If you¡¯re interested in learning more about 591-11-7. The above is the message from the blog manager. Category: benzofurans.

591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is van Rensburg, Helena D. Janse, once mentioned the new application about 591-11-7, Category: benzofurans.

Synthesis and evaluation of methoxy substituted 2-benzoyl-1-benzofuran derivatives as lead compounds for the development adenosine A(l) and/or A(2A) receptor antagonists

A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A(1) and A(2A) receptors via radioligand binding assays to establish the structure activity relationships pertinent for A(1) and A(2A) affinity. Compound 3j (6,7-dimethoxybenzofuran-2-yl)(3-methoxyphenyl) methanone exhibited A(1) affinity (A(1)K(i) (rat) = 6.880 mu M) as well as A(2A) affinity (A(2A)K(i) (rat) = 0.5161 mu M). Compounds 3a-b & 3i-k exhibited selective affinity towards A(1) with K-i values below 10 mu M. The results indicate that C6,7-diOCH(3) substitution on ring A in combination with meta (C3′)-OCH3 substitution on ring B is beneficial for A(1) and A(2A )affinity and activity. Compounds 3a-b & 3j-k showed low cytotoxicity. Upon in vitro and in silico evaluation, compound 3j may be considered lead-like (i.e. a molecular entity suitable for optimization) and, thus, of value in the design of novel, potent and selective adenosine A(1) and A(2A) receptor antagonists.

If you¡¯re interested in learning more about 591-11-7. The above is the message from the blog manager. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem