Heterocyclic Building Block-benzofuran

Electric Literature of 24673-56-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, molecular formula is C10H8O3. In a article，once mentioned of 24673-56-1

The development of a palladium-catalyzed decarboxylative coupling reaction of arene carboxylates with olefinic substrates is described. The optimized procedure for decarboxylative palladation employs Pd(O2CCF3)2 as catalyst (0.2 equiv) in the presence of Ag2CO3 (3 equiv) in the solvent 5% DMSO-DMF and proceeds at temperatures of 80-120 C with a wide range of arene carboxylates and alkenes as substrates. The process is proposed to proceed by an initial Ar-SE reaction involving ipso attack of an electrophilic Pd(II) intermediate on an arene carboxylate to form an arylpalladium(II) species with loss of carbon dioxide. This intermediate is then proposed to react with an olefinic substrate by steps common to the Heck coupling process. Reoxidation of the liberated Pd(0) in situ is proposed to establish the catalytic cycle. Copyright

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Benzofuran – Wikipedia,
Benzofuran | C8H2763O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 652-12-0, name is Tetrafluorophthalic anhydride, introducing its new discovery. Quality Control of Tetrafluorophthalic anhydride

This review focuses on a new generation of polymers with intrinsic microporosity (PIMs) and their hydrogen storage applications. PIMs are a novel microporous material attracting attention due to their potentially useful functional properties. In this review, the methods of synthesis, suitable characterisation techniques and applications are briefly described. Importantly, the hydrogen capacity of PIMs that have been investigated recently is highlighted and the hydrogen uptake is compared to other microporous materials such as hypercrosslinked polymers (HCPs), metal organic frameworks (MOFs) and activated carbons. This review brings H2storage-applicable PIMs that have been reported in different studies together for the first time, providing a reference for better comparison of H2storage in PIMs.

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Benzofuran – Wikipedia,
Benzofuran | C8H3758O – PubChem

Synthetic Route of 4265-16-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Article，once mentioned of 4265-16-1

The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX-9065a.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1037O – PubChem

4265-25-2, Name is 2-Methylbenzofuran, belongs to benzofurans compound, is a common compound. HPLC of Formula: C9H8OIn an article, once mentioned the new application about 4265-25-2.

The influence of the heating rate and of the presence of oxygen on the decomposition pathways and on the decomposition product yields obtained from the thermal degradation of electronic boards containing brominated flame retardants was investigated. TG-FTIR techniques and a fixed bed batch reactor coupled to different analytical techniques were used to simulate different thermal degradation conditions. The qualitative and quantitative yields of decomposition products at different heating rates and in different reaction environments were obtained and compared to those from the decomposition of the unlinked resin and of tetrabromobisphenol A. Bromine was mainly evolved in the gaseous fraction for all the materials and the experimental conditions considered, although significant quantities are present as well in the condensable fraction. An increase of bromine evolved as gaseous hydrogen bromide was evidenced at higher heating rates. In the presence of oxygen, PBDD and PBDF were detected among the decomposition products. The possible precursors and the likely radical reaction pathways leading to the formation of these compounds were identified on the basis of the experimental data. The results obtained confirm that the formation of highly hazardous organobrominated compounds may be expected from the combustion of electronic scrap and of materials containing brominated flame retardants.

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Benzofuran – Wikipedia,
Benzofuran | C8H38O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 3-Methylbenzofuran-2-carboxylic acid, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 24673-56-1

A variety of beta-aryl ketones and aldehydes were facilely synthesized via a Pd(II)/Ag2CO3-mediated decarboxylative Heck type reaction between readily available benzoic acid derivatives and allylic alcohols under mild conditions. The control experiments indicated that this transformation may proceed via a hydrogen migration process.

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Benzofuran – Wikipedia,
Benzofuran | C8H2750O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 6-Bromobenzofuran, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 128851-73-0, name is 6-Bromobenzofuran. In an article，Which mentioned a new discovery about 128851-73-0

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

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Benzofuran – Wikipedia,
Benzofuran | C8H3285O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 3-Methylbenzofuran-2-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, molecular formula is C10H8O3

A novel methodology for the decarboxylative Suzuki-Miyaura-type coupling has been established. This process uses iodine or a bromine source as both the decarboxylation mediator and the terminal oxidant, thus avoiding the need for stoichiometric amounts of transition metal salts previously required. Our new protocol allows for the construction of valuable biaryl architectures through the coupling of (hetero)aromatic carboxylic acids with arylboronic acids. The scope of this decarboxylative Suzuki reaction has been greatly diversified, allowing for previously inaccessible non-ortho-substituted aromatic acids to undergo this transformation. The procedure also benefits from low catalyst loadings and the absence of stoichiometric transition metal additives.

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Benzofuran – Wikipedia,
Benzofuran | C8H2769O – PubChem

334022-87-6, Name is 6-Hydroxybenzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. Application In Synthesis of 6-Hydroxybenzofuran-2-carboxylic acidIn an article, once mentioned the new application about 334022-87-6.

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, we developed a novel series of benzothiophene derivatives and their analogues (6-8) that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g inhibited the replication of hRV-B14, A21, and A71, with respective EC50 values of 0.083, 0.078, and 0.015 muM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation analysis on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A molecular docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2891O – PubChem

Application of 16859-59-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16859-59-9, Name is 3-Hydroxyisobenzofuran-1(3H)-one, molecular formula is C8H6O3. In a Patent，once mentioned of 16859-59-9

A method of exchanging a halogen atom of a halide, which has a group containing an acidic proton and in which one or more halogen atom(s) is/are substituted on a carbon atom of the carbon-carbon double bond, with a metal atom by halogen-metal-exchange reaction and introducing an electrophilic reagent into the carbon atom to which the metal atom is attached. The above method is an industrially excellent method of introducing a substituent by halogen-metal exchange reaction.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1429O – PubChem

Related Products of 10242-10-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.10242-10-1, Name is 5-Chlorobenzofuran-2-carboxylic acid, molecular formula is C9H5ClO3. In a article，once mentioned of 10242-10-1

ClC-Ka and ClC-Kb Cl- channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, we followed a rational chemical strategy, accompanied by computational modeling and electrophysiological techniques, to identify the molecular requisites for binding to a blocking or to an activating binding site on ClC-Ka. The major molecular determinant that distinguishes activators from blockers is the level of planarity of the aromatic portions of the molecules: only molecules with perfectly coplanar aromatic groups display potentiating activity. Combining several molecular features of various CLC-K ligands, we discovered that phenyl-benzofuran carboxylic acid derivatives yield the most potent ClC-Ka inhibitors so far described (affinity <10 muM). The increase in affinity compared with 3-phenyl-2-p-chlorophenoxypropionic acid (3-phenyl-CPP) stems primarily from the conformational constraint provided by the phenyl-benzofuran ring. Several other key structural elements for high blocking potency were identified through a detailed structure-activity relationship study. Surprisingly, some benzofuran-based drugs inhibit ClC-Kb with a similar affinity of <10 muM, thus representing the first inhibitors for this CLC-K isoform identified so far. Based on our data, we established a pharmacophore model that will be useful for the development of drugs targeting CLC-K channels. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10242-10-1 Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3192O – PubChem