Heterocyclic Building Block-benzofuran

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Modification of horseradish peroxidase with bifunctional N-hydroxysuccinimide esters: effects on molecular stability》. Authors are Miland, Enda; Smyth, Malcolm R.; Fagain, Ciaran O..The article about the compound:Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinatecas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O).Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Through the article, more information about this compound (cas:70539-42-3) is conveyed.

Horseradish peroxidase (HRP) has been chem. modified with the homobifunctional crosslinking reagents suberic acid N-hydroxysuccinimide ester (SA-NHS) and ethylene glycol bis-succinimidyl succinate (EG-NHS) yielding derivatives of native HRP with enhanced stability in a range of organic solvents. Modification did not cause any loss of activity. It has been shown that these modification reagents react specifically with the ε-amino groups of the six lysine residues of HRP. Stability increased with concentrations of EG-NHS up to a level of 4-5 mg ml-1. A marked difference was observed in the tryptophan fluorescence profiles of native and the EG-NHS peroxidases upon thermoinactivation at 65°. Both modified peroxidases exhibited improved resistance to the denaturant guanidine hydrochloride.

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Benzofuran – Wikipedia,
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Synthetic Route of C18H20N2O12. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Selective calcium-dependent interaction of calmodulin with the head domain of synapsin 1. Author is Hayes, Nandini V. L.; Bennett, Alison F.; Baines, Anthony J..

The calcium-dependent regulatory protein calmodulin is a critical element in the machinery regulating exocytosis at nerve terminals. T. Okabe and K. Sobue (1987) showed that calmodulin interacts with one of the proteins intimately connected with the neuronal exocytotic process, i.e. synapsin 1. Here, the site at which calmodulin interacts with synapsin 1 was studied. It is possible to generate chem. crosslinked Ca2+-dependent complexes between synapsin 1 and calmodulin in vitro, and covalent crosslinking was used in conjunction with calmodulin affinity chromatog. to identify fragments of synapsin 1 that interact with calmodulin. Ca2+-dependent calmodulin binding is restricted to the head domain (residues 1-453 in bovine synapsin 1). Within this domain the binding site is located in a unique 11-kDa Staphylococcus aureus V8 proteinase-generated fragment. This fragment does not contain the site for cAMP-dependent phosphorylation and therefore does not represent the N terminus of the protein.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hirschelmann, R.; Bekemeier, Heinz researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Inhibition of the incorporation of [14C]-leucine into lymphocytes from peritoneal exudate of the rat by cytostatics, antiphlogistics, and selenophenones》 about this compound( cas:129-18-0 ) in Acta Biologica et Medica Germanica. Keywords: lymphocytes peritoneal exudate metabolism; peritoneal exudate lymphocytes metabolism; protein synthesis cytostatics; cytostatics protein synthesis; antiphlogistics protein synthesis; selenophenones protein synthesis; selenium compound protein synthesis. We’ll tell you more about this compound (cas:129-18-0).

Actinomycin C, azathioprine, cyclophosphamide, indomethacin, benzydamine, phenylbutazone, aminophenazone, sodium salicylate, and some new selenophenones (4-alkylseleno-α-alkyl-β-hexamethyleniminophenones) were tested in relation to leucine-14C incorporation into lymphocytes isolated from peritoneal exudate of rats with formaldehyde peritonitis and to depression of the viability of the lymphocytes. It was not possible by these means to discriminate cytostatics from antiphlogistics used in rheumatic diseases. The procedure may be a simple screening test for substances which influence protein synthesis.

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Benzofuran – Wikipedia,
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Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies. Author is Zhu, Dunming; Yang, Yan; Buynak, John D.; Hua, Ling.

In our effort to search for effective carbonyl reductases, the activity and enantioselectivity of a carbonyl reductase from Sporobolomyces salmonicolor have been evaluated toward the reduction of a variety of ketones. This carbonyl reductase (SSCR) reduces a broad spectrum of ketones including aliphatic and aromatic ketones, as well as α- and β-ketoesters. Among these substrates, SSCR shows highest activity for the reduction of α-ketoesters. Aromatic α-ketoesters are reduced to (S)-α-hydroxy esters, while (R)-enantiomers are obtained from the reduction of aliphatic counterparts. This interesting observation is consistent with enzyme-substrate docking studies, which show that hydride transfer occurs at the different faces of carbonyl group for aromatic and aliphatic α-ketoesters. It is worthy to note that sterically bulky ketone substrates, such as 2′-methoxyacetophenone, 1-adamantyl Me ketone, Et 4,4-dimethyl-3-oxopentanoate and Et 3,3-dimethyl-2-oxobutanoate, are reduced to the corresponding alcs. with excellent optical purity. Thus, SSCR possesses an unusually broad substrate specificity and is especially useful for the reduction of ketones with sterically bulky substituents.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonistic effects against single lethal doses of Amanita phalloides. Author is Floersheim, G. L..

Agents with antagonistic effects against phalloidin [17466-45-4] or α-amanitin [23109-05-9] were tested in mice against lethal doses of an extract from the whole mushroom A. phalloides. The following categories of agents reduced lethality of the extract First, agents protecting only against phalloidin such as rifampicin [13292-46-1], Na phenylbutazone [129-18-0] and antamanide [16898-32-1]. Second, silymarin [22888-70-6] and prednisolone [50-24-8] which display both antiamatoxic and marked (silymarin) or moderate (prednisolone [61-33-6]) antiphallotoxic activity. Thioctic acid [1077-28-7] displayed some activity when tested against mid- lethal doses of the extract Cytochrome c [9007-43-6], a chem. with curative potencies against α-amanitin did not reduce the lethality of the extract All of the effective agents acted only when applied prior to the poisoning. The pattern or protective activity would indicate that in mice death after single doses of A. phalloides may follow a qual. particular course which is difficult to ascribe to phallo- or amatoxic effects alone.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yuasa, Yoshifumi; Tsuruta, Haruki published the article 《Practical syntheses of (S)-4-hydroxytetrahydrofuran-2-one, (S)-3-hydroxytetrahydrofuran, and their (R)-enantiomers》. Keywords: hydroxytetrahydrofuranone preparation; hydroxytetrahydrofuran preparation; THF hydroxy preparation; furanol preparation; chlorohydroxybutanoate cyclocondensation kinetics.They researched the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ).HPLC of Formula: 90866-33-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:90866-33-4) here.

Optically active 4-hydroxytetrahydrofuran-2-one was synthesized in good yield from ClCH2CHOHCH2CO2Et (I) by refluxing with dilute HCl. In a similar manner, optically active 3-hydroxytetrahydrofuran was prepared from ClCH2CHOH(CH2)2OH, which was derived from I by NaBH4-reduction These cyclizations proceed without racemization.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Physiological and drug-induced changes in the glycogen content of mouse brain. Author is Hutchins, D. A.; Rogers, Keith James.

The effect of the method of killing on the concentration of glycogen in mouse brain was determined The cerebral glycogen content of mice killed by immersion in liquid N did not differ significantly from that of animals decapitated and the heads immediately frozen. A delay before freezing led to the rapid loss of brain glycogen, with a 17% fall at 10 sec and an 82% loss after 5 min. Hyperglycemia, induced by the administration of D-glucose, resulted in an 8.3% loss of brain glycogen after 120 min. Insulin hypoglycemia produced a 10.7% fall in glycogen at 60 min followed by an 11.2% increase at 120 min. Exposure to either high (32°) or low (10°) ambient temperatures, caused a depletion of brain glycogen. A circadian rhythm of brain glycogen concentration was found, with a nadir which was coincident with the peak of locomotor activity and body temperature Drugs from several pharmacol. classes were studied for their in vivo effect on the concentration of glycogen in mouse brain. Brain glycogen was increased by all the depressant drugs tested, and by some drugs which had little effect on behavior (diphenhydramine, phenytoin and propranolol), or which caused excitation (caffeine and nialamide). Glycogen was depleted only by amphetaminelike compounds or by bemegride-induced convulsions. The results are discussed with particular reference to the possible relation between catechol amines and glycogen metabolism in the brain.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell, published in 1992-02-15, which mentions a compound: 70539-42-3, Name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, Molecular C18H20N2O12, Category: benzofurans.

Bifunctional reagents were used to exam. the subunit composition of the non-DNA-binding form of the rat and human glucocorticoid receptor. Treatment of intact cells and cell extracts with a reversible cross-linker, followed by electrophoretic anal. of immunoadsorbed receptor revealed that 3 proteins of apparent approx. mol. masses, 90, 53, and 14 kDa are associated with the receptor. The 1st of these was identified immunochem. as a 90-kDa heat-shock protein (hsp90). The complex isolated from HeLa cells contained 2.2 mol hsp90/mol steroid-binding subunit. Crosslinking of the receptor complex in the cytosol completely prevented salt-induced dissociation of the subunits. The cross-linked receptor was electrophoretically resolved into 2 oligomeric complexes of apparent mol. mass 288 kDa and 347 kDa, reflecting the association of the 53-kDa protein with a fraction of the receptor. Since no higher oligomeric complexes could be generated by crosslinking cell extracts under different conditions, it was concluded that most of the untransformed cytosolic receptor is devoid of addnl. components.

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Benzofuran – Wikipedia,
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Electric Literature of CAgF3O3S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Synthesis, crystal structure and photophysical properties of bis[2,6-difluoro-3-(pyridin-2-yl)pyridine-κN](trifluoromethanesulfonato-κO)silver(I). Author is Moon, Suk-Hee; Paek, Sanghyun; Kang, Youngjin.

In the title compound, [Ag(CF3SO3)(C10H6F2N2)2], the AgI center adopts a highly distorted trigonal-planar coordination environment resulting from its coordination by one O atom of the trifluoromethanesulfonate anion and the pyridine N atoms of two crystallog. independent 2′,6′-difluoro-2,3′-bipyridine ligands, which display very similar conformations to one another. Pairwise Ag···O-SO2CF3- [Ag···O = 2.8314 (14) Å] interactions and intermol. C-H···O interactions between inversion-related units lead to the formation of an eight-membered cyclic dimer in which the silver atoms are separated by 6.2152 (3) Å. In the crystal, the dimers are linked through C-H···O hydrogen bonds, halogen···π and weak π-π stacking interactions, resulting in the formation of a three-dimensional supramol. network. The title compound exhibits a strong and broad emission band from 400 nm to 550 nm in solution and its photoluminescence quantum efficiency is estimated to be ca 0.2, indicating that the title compound could have applications as an emitting material in organic light-emitting diodes (OLEDs).

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Benzofuran – Wikipedia,
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Product Details of 90866-33-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Production of (R)-ethyl-4-chloro-3-hydroxybutanoate using Saccharomyces cerevisiae YOL151W reductase immobilized onto magnetic microparticles. Author is Choo, Jin Woo; Kim, Hyung Kwoun.

For the synthesis of various pharmaceuticals, chiral alcs. are useful intermediates. Among them, (R)-ethyl-4-chloro-3-hydroxybutanoate ((R)-ECHB) is an important building block for the synthesis of L-carnitine. (R)-ECHB is produced from ethyl-4-chloro-3-oxobutanoate (ECOB) by a reductase-mediated, enantioselective reduction reaction. The Saccharomyces cerevisiae YOL151W reductase that is expressed in Escherichia coli cells exhibited an enantioselective reduction reaction toward ECOB. By virtue of the C-terminal His-tag, the YOL151W reductase was purified from the cell-free extract using Ni2+-NTA column chromatog. and immobilized onto Ni2+-magnetic microparticles. The phys. properties of the immobilized reductase (Imm-Red) were measured using electron microscopy, a magnetic property measurement system, and a zeta potential system; the average size of the particles was approx. 1 μm and the saturated magnetic value was 31.76 emu/g. A neodymium magnet was used to recover the immobilized enzyme within 2 min. The Imm-Red showed an optimum temperature at 45°C and an optimum pH at 6.0. In addition, Bacillus megaterium glucose dehydrogenase (GDH) was produced in the E. coli cells and was used in the coupling reaction to regenerate the NADPH cofactor. The reduction/oxidation coupling reaction composed of the Imm-Red and GDH converted 20 mM ECOB exclusively into (R)- ECHB with an e.e.p value of 98%.

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Benzofuran – Wikipedia,
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