Heterocyclic Building Block-benzofuran

Yu, Longhui; Liu, Jun; Wang, Hongyu; Xu, Lijun; Wu, Yufei; Zheng, Changwu; Zhao, Gang published the artcile< Asymmetric Dieckmann Condensation towards Spirocyclic Oxindoles Catalyzed by Amino Acid-derived Phosphonium Salts>, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one, the main research area is oxoindolinyl methylbenzenecarboxylate phosphonium salt catalyst enantioselective Dieckmann condensation; spiroindeneoxindole preparation.

An asym. Dieckmann condensation towards spirocyclic oxindoles and aza-oxindoles catalyzed by amino acid-derived phosphonium salt was developed, which expanded the applicability of asym. phosphonium salt catalysis in the production of 1,3-dicarbonyl compounds This reaction was distinguished by its mild conditions (-20°C), low catalyst loading (3-5 mol%), and broad substrate scope (25 examples). Control experiments revealed that both the catalyst’s phosphonium skeleton and H-bonding site were required. Product transformations and a gram scale experiment were also carried out.

Advanced Synthesis & Catalysis published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Heng; Song, Qing; Yu, Guangjun; Cao, Zhongcheng; Qiang, Xiaoming; Liu, Xiuxiu; Deng, Yong published the artcile< Phthalimide-(N-alkylbenzylamine) cysteamide hybrids as multifunctional agents against Alzheimer's disease: Design, synthesis, and biological evaluation>, HPLC of Formula: 531-88-4, the main research area is Alzheimer disease amino acid BBB AChE anitioxidant human; Alzheimer’s disease; acetylcholinesterase inhibition; anti-Aβ aggregation; antioxidant; multi-target agents; neuroprotective effect; phthalimide-(N-alkylbenzylamine)cysteamide hybrids.

The complex pathogenesis of Alzheimer’s disease (AD) calls for multi-target approach for disease treatment. Herein, based on the MTDLs strategy, a series of phthalimide-(N-alkylbenzylamine) cysteamide hybrids were designed, synthesized, and investigated in vitro for the purpose. Most of the target compounds were found to be potential multi-target agents. In vitro results showed that compound 9e was the representative compound in this series, endowed with high EeAChE and HuAChE inhibitory potency (IC50 = 1.55μM and 2.23μM, resp.), good inhibitory activity against self-induced Aβ1-42 aggregation (36.08% at 25μM), and moderate antioxidant capacity (ORAC-FL value was 0.68 Trolox equivalent). Mol. docking studies rationalized the binding mode of 9e in both PAS and CAS of AChE. Moreover, 9e displayed excellent ability to against H2O2-induced PC12 cell injury and penetrate BBB. Overall, these results highlighted that compound 9e was an effective and promising multi-target agent for further anti-AD drug development.

Chemical Biology & Drug Design published new progress about Alzheimer disease. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, HPLC of Formula: 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wang; Feng, Zili; Hu, Daihua; Meng, Jin published the artcile< Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors>, HPLC of Formula: 531-88-4, the main research area is arylnaphthalene lignan lactone derivative topoisomerase inhibitor design antitumor activity; Arylnaphthalene lignin lactones; anti-proliferation activity; catalytic inhibitor; cell proliferation assay; chemotherapeutic agents; topoisomerase IIα..

Arylnaphthalene lignan lactones are a class of natural products containing the phenyl-naphthyl skeleton. Some arylnaphthalene lignan lactones have been used in clin. practice as antitumor agents, due to their cytotoxicity and inhibitory activities against DNA topoisomerase I (Topo I) and topoisomerase II (Topo II). This study presents the design and synthesis of arylnaphthalene lignan lactones derivatives The inhibitory activities against Topo I and Topo IIα and antitumor activities of these compounds were assayed. A series of arylnaphthalene lignan lactones derivatives have been designed and synthesized, using the Diels-Alder reaction and Suzuki reaction as the key steps. Their antiproliferation activities were evaluated by sulforhodamine B assay on human breast cancer MDAMB-231, MDA-MB-435 and human cervical cancer HeLa cells. DNA relaxation assays were employed to examine the inhibitory activity of compounds 1-22 on Topo I and Topo IIα in vitro. Flow cytometry anal. was performed to study the drug effects on cell cycle progressions. Seven compounds exhibited the modest anti-proliferation activity with IC50 values between 1.36 and 20 μM. Compounds 3, 19 and 22 showed potent inhibitory activities with IC50 values less than 1 μM. DNA relaxation assay revealed that compound 22 showed potent inhibitory activity against Topo IIα in vitro. Compound 22 also induced DNA breaks in MDA-MB-435 cells evidenced by comet tails and the accumulation of γ-H2AX foci. The ability of 22 in inducing DNA breaks mediated by Topo IIα resulted in G2/M phase arrest and apoptosis. This work indicates that arylnaphthalene lignan lactones derivatives represent a novel type of Topo IIα inhibitory scaffold for developing new antitumor chemotherapeutic agents.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Antiproliferative agents. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, HPLC of Formula: 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Du, Tian; Gao, Ruiheng; Deng, Yunfeng; Wang, Cheng; Zhou, Qian; Geng, Yanhou published the artcile< Indandione-Terminated Quinoids:Facile Synthesis by Alkoxide-Mediated Rearrangement Reaction and Semiconducting Properties>, Related Products of 531-88-4, the main research area is indandione terminated quinoid preparation alkoxide rearrangement semiconductor; aromatic dialdehydes; electron transport; indandione; organic thin-film transistor; quinoidal compounds.

A series of 1,3-indandione-terminated π-conjugated quinoids were synthesized by alkoxide-mediated rearrangement reaction of the resp. alkene precursors, followed by air oxidation This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels <-4.0 eV and molar absorptivities >105 L mol-1 cm-1. The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier MOs over the entire mol. skeleton involving aryl termini. n-Channel organic thin-film transistors with electron mobility of up to 0.38 cm2 V-1 s-1 were fabricated, showing the potential of this new class of quinoids as organic semiconductors.

Angewandte Chemie, International Edition published new progress about Crystal structure. 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Related Products of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lei, Zhen-Yao; Hu, Kui; He, Yuan-Xiang; Geng, Shu; Chen, Li-Na; Zou, Shuai; Pan, Li; Ding, Zhi-Jun; Huang, Feng published the artcile< Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones>, Reference of 531-88-4, the main research area is isoindolinone isoquinolinone preparation; alkenyl amide visible light radical cyclization.

An efficient N-centered radical intramol. cyclization reaction of alkenyl amides induced by visible light was described. In this process, an alkenyl amide underwent 5-exo/6-endo cyclization to selectively yield two critical alkaloid structures, namely isoindolinones and isoquinolinones.

Organic & Biomolecular Chemistrypublished new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (alkenyl). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Reference of 531-88-4.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Bin; Zhou, Xigeng published the artcile< Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane>, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one, the main research area is phenylenedimethanol preparation isobenzofuranone reduction base silane.

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, was developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and γ-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.

Chinese Chemical Letterspublished new progress about Bases Role: RGT (Reagent), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Li, Junxuan; Zhou, Jinlei; Wang, Yumei; Yu, Yue; Liu, Qiang; Yang, Tilong; Chen, Huoji; Cao, Hua published the artcile< Mechanistic insight into the synergistic Cu/Pd-catalyzed carbonylation of aryl iodides using alcohols and dioxygen as the carbonyl source>, Category: benzofurans, the main research area is aryl iodide alc carbonylation dioxygen carbonyl source mechanistic insight.

Pd-catalyzed carbonylation, as an efficient synthetic approach for the installation of carbonyl groups in organic compounds, has been one of the most important research fields in the past decade. Although elegant reactions that allow highly selective carbonylations have been developed, straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical applications. Here, authors show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcs. and dioxgen as the carbonyl sources. A broad range of aryl iodides and alcs. are compatible with this protocol. The reaction is concise and practical due to the ready availability of the starting materials and the scalability of the reaction. In addition, the reaction affords lactones and lactams in an intermol. fashion. Moreover, DFT calculations have been performed to study the detailed mechanisms.

Science China: Chemistrypublished new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ibrahimi, Maroua; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Vanelle, Patrice published the artcile< Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy>, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one, the main research area is benzylphthalide preparation; nitrobenzyl chloride tetrakisdimethylaminoethylene formylbenzoate nucleophilic addition.

A one-pot synthesis of new 3-benzylphthalide derivatives I (X = CH, N; R1 = 4-NO2, 3-OMe-4-NO2, 2-NO2-4-C6H4, etc.; R2 = 4-CN, 5-Cl, 4-COOMe, etc.) was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with Me 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3H)-one products in moderate to good yields.

Synlettpublished new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem