Ibrahimi, Maroua; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Vanelle, Patrice published the artcile< Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy>, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one, the main research area is benzylphthalide preparation; nitrobenzyl chloride tetrakisdimethylaminoethylene formylbenzoate nucleophilic addition.
A one-pot synthesis of new 3-benzylphthalide derivatives I (X = CH, N; R1 = 4-NO2, 3-OMe-4-NO2, 2-NO2-4-C6H4, etc.; R2 = 4-CN, 5-Cl, 4-COOMe, etc.) was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with Me 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3H)-one products in moderate to good yields.
Synlettpublished new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 531-88-4 belongs to class benzofurans, and the molecular formula is C10H10O4, Recommanded Product: 5,6-Dimethoxyisobenzofuran-1(3H)-one.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem