Heterocyclic Building Block-benzofuran

Graham, Samuel L. published the artcileTopically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides, HPLC of Formula: 50551-63-8, the main research area is benzofuransulfonamide preparation carbonic anhydrase inhibition; indolesulfonamide preparation carbonic anhydrase inhibition; carbonic anhydrase inhibition benzofuransulfonamide indolesulfonamide; ocular hypotensive benzofuransulfonamide indolesulfonamide; glaucoma treatment indolesulfonamide benzofuransulfonamide.

Derivatives of 2-benzofuran- and 2-indolesulfonamide (e.g., I, II) were prepared for evaluation as topically active ocular hypotensive agents. These compounds were excellent inhibitors of carbonic anhydrase and lowered intraocular pressure in a rabbit model of ocular hypertension. However, their development for clin. use was precluded because they cause dermal sensitization in guinea pigs. A correlation between electrophilicity, as assessed by in vitro reactivity with reduced glutathione, and dermal sensitization potential was further documented.

Journal of Medicinal Chemistry published new progress about Allergens Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Henry, Martyn C. published the artcileSynthesis of Benzo[b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis, Category: benzofurans, the main research area is benzofuran preparation regioselective; aryl alkyl ketone halogenation arylation iron copper catalyst.

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogs, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), RACT (Reactant or Reagent). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fang, Huaquan published the artcileA Pincer Ruthenium Complex for Regioselective C-H Silylation of Heteroarenes, Quality Control of 50551-63-8, the main research area is pincer ruthenium complex catalyst regioselective silylation heteroarene; heteroaryl silane preparation regioselective Hiyama Denmark coupling iodobenzene.

A pincer Ru(II) catalyst for the highly efficient undirected silylation of O- and S-heteroarenes with (TMSO)2MeSiH and Et3SiH is described, producing heteroarylsilanes with exclusive C2-regioselectivity, good functional-group tolerance, and high turnover numbers (up to 1960). The synthetic utility of the silylated products is demonstrated by Pd-catalyzed Hiyama-Denmark cross-coupling under mild conditions. One-pot, two-step silylation and coupling procedures have been also developed.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Bang-Le published the artcileA new efficient method for the total synthesis of linear furocoumarins, Product Details of C9H8O2, the main research area is furocoumarin total synthesis; psoralen total synthesis; benzofuran preparation; nitroalkyl phenol Nef oxidation intramol cyclocondensation.

A new efficient method for the synthesis of linear furocoumarins by a Nef reaction and intramol. cyclocondensation in one pot results in the construction of a benzofuran ring. This method provides a new strategy to furnish the benzofuran framework easily, and also allows the convenient synthesis of furocoumarin derivatives with different substituents on the coumarin ring by a subsequent Pechmann reaction. This strategy has also been applied to the preparation of four addnl. benzofuran derivatives

Synlett published new progress about Coumarins Role: SPN (Synthetic Preparation), PREP (Preparation). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Product Details of C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nath, Sarbasri published the artcileFast Synthesis of Benzofurans from Coumarins, Application In Synthesis of 50551-63-8, the main research area is coumarin zinc oxide catalyst microwave irradiation ring contraction; benzofuran preparation green chem.

A new solid support, Zinc oxide was used as a green catalyst for the ring contraction of coumarins to benzofurans. Employing microwave induced synthesis whenever possible, minimizing the use of toxic solvents. Benzofurans was achieved from coumarins by ring contraction reaction in single step. Microwave irradiation was used to shorten the reaction time and to improve the yield.

Journal of Ultra Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Application In Synthesis of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sun, Nan published the artcileZeolite-catalyzed synthesis of 2,3-unsubstituted benzo[b]furans via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals, Synthetic Route of 50551-63-8, the main research area is benzofuran preparation tin exchanged zeolite catalyst cyclization aryloxyacetaldehyde acetal.

An efficient and environmentally benign heterogeneous catalytic process for the synthesis of 2,3-unsubstituted benzo[b]furans was established via the intramol. cyclization of 2-aryloxyacetaldehyde acetals. By using tin-exchanged H-β zeolite (Sn-β) as catalyst, a wide range of functionalized 2,3-unsubstituted benzo[b]furans could be prepared in good to excellent yields. The Sn-β zeolite catalyst also exhibited excellent shape selectivity on the cyclization of meta-substituted 2-aryloxyacetaldehyde acetals, and 6-substituted isomers were preferably formed up to 97% regio-selectivity. Moreover, Sn-β zeolite could be easily recovered and reused without any noticeable activity loss.

Tetrahedron published new progress about Beta zeolites Role: CAT (Catalyst Use), USES (Uses) (tin-exchanged). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Synthetic Route of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yoshida, N. published the artcileReductive dechlorination of PCBs and other chlorinated compounds by novel anaerobic bacterial species, Formula: C8H5ClO2, the main research area is anaerobic bacteria polychlorinated biphenyl chlorinated compound reductive dechlorination.

Bacteria that can reductively dechlorinate chlorinated compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) have been receiving much attention in the field of environmental science and technol. In this study, the enrichment of bacteria that dechlorinate PCBs and PCDDs was performed by the sequentially transferred culture amended with 4,5,6,7-tetrachlorophthalide (fthalide) and single fatty acids from an uncontaminated paddy field. The enrichment cultures amended with lactate (KFL) or formate (KFF) maintained the activity to dechlorinate fthalide to 4-chlorophthalide in the sequential transfer but not the culture amended with acetate and butyrate. The only KFL-culture dechlorinated diverse chlorinated compounds including 2,3,4,5-tetrachlorobiphenyl, 2,3,4-trichlorobiphenyl, 1,2,3-trichlorodibenzo-p-dioxin. A further enrichment of KLF-culture provided an enrichment culture, KFC4A-culture, containing uniformly small short rods. Microbial community anal. based on 16S rRNA genes revealed the involvement of two phylogenetically distinct operational taxonomic units (OTUs) of Dehalobacter sp. (FTH1 and FTH2) with the dechlorination of chlorinated compounds Dehalobacter restrictus TEA was their closest relative, and had 97.5% and 97.3% of 16SrRNA gene similarities for FTH1 and FTH2, resp. These results demonstrate the capacity of uncontaminated paddy soil to dechlorinate PCBs and PCDDs, and the involvement of Dehalobacter sp.

Organohalogen Compounds published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Formula: C8H5ClO2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yoshida, Naoko published the artcileA novel Dehalobacter species is involved in extensive 4,5,6,7-tetrachlorophthalide dechlorination, Category: benzofurans, the main research area is novel Dehalobacter tetrachlorophthalide dechlorination waste fungicide rice blast Dehalobacter.

The purpose of this study was the enrichment and phylogenetic identification of bacteria that dechlorinate 4,5,6,7-tetrachlorophthalide (com. designated “”fthalide””), an effective fungicide for rice blast disease. Sequential transfer culture of a paddy soil with lactate and fthalide produced a soil-free enrichment culture (designated the “”KFL culture””) that dechlorinated fthalide by using hydrogen, which is produced from lactate. Phylogenetic anal. based on 16S rRNA genes revealed the dominance of two novel phylotypes of the genus Dehalobacter (FTH1 and FTH2) in the KFL culture. FTH1 and FTH2 disappeared during culture transfer in medium without fthalide and increased in abundance with the dechlorination of fthalide, indicating their growth dependence on the dechlorination of fthalide. Dehalobacter restrictus TEA is their closest relative, with 97.5% and 97.3% 16S rRNA gene similarities to FTH1 and FTH2, resp.

Applied and Environmental Microbiology published new progress about Dechlorination. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tabanca, Nurhayat published the artcileGas chromatographic-mass spectrometric analysis of essential oils from Pimpinella aurea, Pimpinella corymbosa, Pimpinella peregrina and Pimpinella puberula gathered from Eastern and Southern Turkey, Application In Synthesis of 13391-27-0, the main research area is Pimpinella essential oil terpene phenylpropanoid.

Essential oils from fruits, stems and leaves and roots of Pimpinella aurea DC., P. corymbosa Boiss., P. peregrina L. were analyzed by gas chromatog. (GC) and gas chromatog.-mass spectrometry (GC-MS) techniques. Fruits and aerial parts of P. puberula (DC.) Boiss were also evaluated. A total of 140 different compounds were identified, and significant qual. and quant. differences were observed among the samples. In fact, the main constituents of each species were different and only the oils extracted from roots shared the same principal compound, epoxy pseudoisoeugenyl-2-Me butyrate (26.8-42.8%). The other fractions were dominated by different sesquiterpene compounds although in three of them, P. aurea stem and leaves, P. puberula fruits and P. puberula stems and leaves, monoterpene constituents also appear as main ones.

Journal of Chromatography A published new progress about Gas chromatography. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Application In Synthesis of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Moock, Daniel published the artcileEnantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis, Category: benzofurans, the main research area is octahydrobenzofuran enantioselective preparation; benzofuran preparation enantioselective hydrogenation cascade catalyst; benzofuran; cascade catalysis; enantioselective hydrogenation; heterogeneous catalysis; homogeneous catalysis.

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive mols. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem