Heterocyclic Building Block-benzofuran

Arbatsky, I. W. published the artcileTitration theory of dilute solutions, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Zeitschrift fuer Analytische Chemie (1938), 117-26, database is CAplus.

The theory of titrating dilute solutions is discussed with respect to the magnitude of the error and the determination of the proper correction values. The titration of carbonates with phenolphthalein and α-naphtholphthalein as indicators is discussed in detail and the formulas for determining the correction factor are worked out. The advantages of the latter indicator are pointed out with respect to this titration.

Zeitschrift fuer Analytische Chemie published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Guo, Fang published the artcileMoracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation, COA of Formula: C14H10O4, the publication is International Immunopharmacology (2018), 80-86, database is CAplus and MEDLINE.

Moracin M, a phenolic component obtained from Mori Cortex, has been reported to have anti-inflammatory activities. The present study was designed to investigate the effects and mechanisms of Moracin M on lipopolysaccharide (LPS)-treated nucleus pulposus cells (NPCs) in intervertebral disk. NPCs were treated with moracin M at different concentrations for 1 h and then stimulated with LPS (0.5μg/mL) for 24 h. The result demonstrated that moracin M could significantly inhibit LPS-induced inflammation. The elevated levels of IL-1β, TNF-α and IL-6 induced by LPS could be reversed by moracin M in NPCs. Moreover, moracin M increased the expressions of autophagy-related proteins and up-regulated the phosphorylation of PI3K/Akt/mTOR in LPS-treated NPCs. In conclusion, our data demonstrated that moracin M might inhibit LPS-induced PI3K and Akt phosphorylation, which leading to promote the autophagy and inhibit the inflammatory mediator production in NPCs.

International Immunopharmacology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, COA of Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhong, Zhuoheng published the artcileMolecular characterization of a geranyl diphosphate-specific prenyltransferase catalyzing stilbenoid prenylation from Morus alba, Application In Synthesis of 56317-21-6, the publication is Plant and Cell Physiology (2018), 59(11), 2214-2227, database is CAplus and MEDLINE.

Pharmaceutically active compounds from medical plants are attractive as a major source for new drug development. Prenylated stilbenoids with increased lipophilicity are valuable secondary metabolites which possess a wide range of biol. activities. So far, many prenylated stilbenoids have been isolated from Morus alba but the enzyme responsible for the crucial prenyl modification remains unknown. In the present study, a stilbenoid-specific prenyltransferase (PT), termed Morus alba oxyresveratrol geranyltransferase (MaOGT), was identified and functionally characterized in vitro. MaOGT recognized oxyresveratrol and geranyl diphosphate (GPP) as natural substrates, and catalyzed oxyresveratrol prenylation. Our results indicated that MaOGT shared common features with other aromatic PTs, e.g. multiple transmembrane regions, conserved functional domains and targeting to plant plastids. This distinct PT represents the first stilbenoid-specific PT accepting GPP as a natural prenyl donor, and could help identify addnl. functionally varied PTs in moraceous plants. Furthermore, MaOGT might be applied for high-efficiency and large-scale prenylation of oxyresveratrol to produce bioactive compounds for potential therapeutic applications.

Plant and Cell Physiology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C19H14O2, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hu, Qiu-Fen published the artcileAntiviral Phenolic Compounds from Arundina graminifolia, Formula: C14H10O4, the publication is Journal of Natural Products (2013), 76(2), 292-296, database is CAplus and MEDLINE.

Five new phenolic compounds, gramniphenols C-G (I–V), and eight known compounds (6-13) were isolated from the whole plant of Arundina graminifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC₅₀ values of 20.8, 40.8, and 57.7 μM, resp. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.

Journal of Natural Products published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Cao, Yan-gang published the artcileTwo new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity, Related Products of benzofurans, the publication is Natural Product Research (2018), 32(4), 391-398, database is CAplus and MEDLINE.

A new biphenyl-furocoumarin, named morescoumarin A, and a new prenylated flavanone, named morflavanone A were isolated from the root bark of Morus alba L., together with four known compounds Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zha, Gao-Feng published the artcilePalladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides, Product Details of C8H5IO, the publication is Angewandte Chemie, International Edition (2017), 56(17), 4849-4852, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂, ethenesulfonyl fluoride underwent chemo-, regio- and diastereoselective aerobic Heck reactions with aryl, heteroaryl, and vinyl iodides mediated by silver trifluoroacetate in acetone to yield arylvinylsulfonyl fluorides such as (E)-PhCH:CHSO₂F and (E,E)-PhCH:CHCH:CHSO₂F in 24-99% yields. The structure of (E,E)-PhCH:CHCH:CHSO₂F was determined by x-ray crystallog.

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C11H22N2O4, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Shang-Ke published the artcileMoracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor, Application In Synthesis of 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(9), 3261-3264, database is CAplus and MEDLINE.

Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug ‘Sang-Bai-Pi’ (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC₅₀ values of 2.9, 4.5, >40, and >100 μM, resp. Our mol. docking and 8 ns mol. dynamics (MD) simulations demonstrated that moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics anal. of its analog moracin C was carried out to qual. validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Jing, Ying published the artcileChemical constituents from the leaves of Morus mongolica, Category: benzofurans, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2010), 22(2), 181-184, database is CAplus.

Chem. constituents of the leaves of Morus mongolica were isolated and purified by ion-exchange resin, silica gel, ODS and Sephadex LH-20 column chromatogs. Their structures were elucidated on the basis of physico-chem. properties and spectral data. Ten compounds were identified as 1-deoxynojirimycin (1), fagomine (2), myoinositol (3), moracin M (4), 3-O-β-D-glucopyranoside (5), umbelliferone (6), scopoletin (7), syringaresinol (8), 2,4,2′,4′-tetrahydroxychalcone (9), and daucosterol (10), resp. Compounds 2, 3, 5-10 were isolated from this plant for the first time, and compound 9 is a new natural product.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Pei-Song published the artcileTwo new 2-arylbenzofurans from the stems of Nicotiana tabacum and their bioactivities, SDS of cas: 56317-21-6, the publication is Heterocycles (2016), 92(8), 1462-1467, database is CAplus.

Two new 2-arylbenzofurans, 4-(7-methoxy-3,5-dimethyl-benzofuran-2-yl)phenol (1), 4-(6-methoxy-3,5-dimethylbenzofuran-2-yl)-phenol (2), together with two known 2-arylbenzofurans (3 and 4) were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-4 were tested for their anti-TMV and cytotoxicity activities. The results showed that compound 2 exhibited high anti-TMV activities with inhibition rates of 36.4% at the concentration of 20 μM. This rate is higher than that of pos. control. Compounds 1-4 showed moderate-to-weak cytotoxicities against some tested human tumor cell lines with IC50 values in the range of 2.2-8.4 μM.

Heterocycles published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C15H20BNO3, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Hua published the artcileA Construction of α-Alkenyl Lactones via Reduction Radical Cascade Reaction of Allyl Alcohols and Acetylenic Acids, Formula: C8H5IO, the publication is Organic Letters (2020), 22(21), 8337-8344, database is CAplus and MEDLINE.

An iron-catalyzed cascade reaction of radical reduction of allyl alcs. and acetylenic acids to construct polysubstituted α-alkenyl lactones has been developed. In this paper, various allyl alcs. can form allyl ester intermediates and are further transformed into alkyl radicals, which form products through intramol. reflex-Michael addition In addition, this method can be used to prepare spirocycloalkenyl lactones. Interestingly, this protocol can be used to synthesize the skeleton structure of natural products. Moreover, the product can be further transformed into a β-methylene THF and THF diene.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C10H19NO3, Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem