Heterocyclic Building Block-benzofuran

Infrared spectra of some substituted benzofuran derivatives was written by Epstein, W. W.;Horton, W. J.;Lin, C. T.. And the article was included in Journal of Organic Chemistry in 1965.Recommanded Product: 1646-27-1 This article mentions the following:

The ir spectra of a number of simple and complex substituted benzofurans (I) were studied. The findings indicated a relationship between the presence or absence of furan H atoms and medium to strong bands in the 1020-1180-cm.^-1 region. I were divided into 2 groups. One group wherein R¹ = H and the 2nd group in which R¹ = COMe, CO₂Me, CO₂H, iso-Pr, iso-PrCO, C:CHMe, and COCH₂COMe. The 1st had 2 bands, one in the 1125-1160cm.^-1 region and the other in the 1029-1087-cm.^-1 region associated with the in-plane bending modes of the β- and α-H atoms on the furan nucleus. The 2nd had only 1 band at 1121-1172 cm.^-1 characteristic of the β-H. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of 14 sulfonamide residues in shrimps by high performance liquid chromatography coupled with post-column derivatization was written by Huang, Dongmei;Huang, Xuanyun;Gu, Runrun;Hui, Yunhua;Tian, Liangliang;Feng, Bing;Zhang, Xuan;Yu, Huijuan. And the article was included in Sepu in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

A method for the determination of 14 sulfonamide residues in shrimps by high performance liquid chromatog. coupled with post-column derivatization was established. The sulfonamide residues were extracted with Et acetate after adding sulfapyridine as internal standard The extracts were vacuum-concentrated and reverse-extracted by 2 mol/L hydrochloric acid solution for clean-up, and then the hydrochloric acid solution was defatted with n-hexane. The solution after filtration was blended with a mixed solution of methanol, acetonitrile and 3.5 mol/L sodium acetate solution (5:5:20, volume/volume/v). The sulfonamides were separated on a C₁₈ column by RP-HPLC and online derivatized with a fluorescamine and detected with a fluorescence detector. The standard addition method was used for quant. anal. The parameters of post-column derivatization system, such as concentration of fluorescamine solution, velocity of reagent solution and reaction temperature, were optimized. The calibration curves of the method showed good linearity in the range of 5-200 μg/L. The limits of quantification (LOQ, S/N = 10) were 1.0-5.0 μg/kg for the 14 sulfonamides. The recoveries were 77.8%-103.6% in the spiked range of 1.0-100.0 μg/kg in shrimps with the relative standard deviations of 2.9%-9.1% (n = 6). The results indicated that the method is sensitive, efficient and more accurate. It is suitable for the simultaneous determination of the 14 sulfonamide residues in shrimps. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Protein Quantitation and Analysis of Purity was written by Campion, Eva M.;Loughran, Sinead T.;Walls, Dermot. And the article was included in Methods in Molecular Biology (New York, NY, United States) in 2017.Formula: C17H10O4 This article mentions the following:

The accurate quantitation of proteins and an anal. of their purity are essential in numerous areas of scientific research, and is a critical factor in many clin. applications. The large number and variety of techniques employed for this purpose is therefore not surprising. The selection of a suitable assay is dependent on such factors as the level of sensitivity required, the presence of interfering agents, and the composition of the protein itself. Here, protocols for the most commonly used protein determination methodologies are outlined, as well as for the more recently adapted technique of quant. immuno-Polymerase Chain Reaction. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization, antimicrobial and in-silico studies of (1,1-dibenzofuran-2-yl) ethyl terephthalamide derivatives was written by Gurunathan, Krishnaswamy;R., Desai Nivedita;Hanuma, Naika Raja Naika;B., Aruna Kumar Doyijode;S., Sreenivasa. And the article was included in Research Journal of Chemistry and Environment in 2021.HPLC of Formula: 38220-75-6 This article mentions the following:

In search of new benzofuran derivatives of biol. importance, sym. terephthalamide derivatives I [R = H, Cl, Br; R¹ = H, Cl, Br] of benzofuran were synthesized from 2- acetylbenzofuran. The synthesis of title compounds followed a sequence of condensation, reduction and coupling reactions. The structures of all the newly synthesized compounds were established by FT-IR, ¹H and ¹³C NMR and MS spectral methods. The formation of amine follows novel reduction method under microwave irradiation All the synthesized compounds I, II and III were subjected to invitro antimicrobial studies and found to be moderate antibacterial agent and poor antifungal agents. In correlation, the mode of action of these compounds I, II and III as antimicrobial agents was determined by the in-silico studies. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6HPLC of Formula: 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Characterisation of nociception and inflammation observed in traumatic muscle injury model in rats was written by Kudsi, Sabrina Qader;Antoniazzi, Caren Tatiane de David;Camponogara, Camila;Brum, Evelyne da Silva;Brusco, Indiara;Peres, Diulle Spat;Fischer, Susana Paula Moreira;Dalenogare, Diessica Padilha;Stein, Carolina dos Santos;Zaccaron, Rubya Pereira;Silveira, Paulo Cesar Lock;Moresco, Rafael Noal;Oliveira, Sara Marchesan;Trevisan, Gabriela. And the article was included in European Journal of Pharmacology in 2020.COA of Formula: C20H10Cl2O5 This article mentions the following:

Muscle pain is the most prevalent type of pain in the world, but treatment remains ineffective. Thus, it is relevant to develop trustable animal models to understand the involved pain mechanisms. Therefore, this study characterised the nociception and inflammation in a traumatic muscle injury model in rats. A single blunt trauma impact on the right gastrocnemius muscle of male Wistar rats (250-350 g) was used as model for muscle pain. Animals were divided into four groups (sham/no treatment; sham/diclofenac 1%; injury/no treatment; injury/diclofenac 1%) and the topical treatment with a cream containing 1% monosodium diclofenac (applied at 2, 6, 12, 24, and 46 h after muscle injury; 200 mg/muscle) was used as an anti-inflammatory control. Nociception (mech. and cold allodynia, or nociceptive score) and locomotor activity were evaluated at 26 and 48 h after injury. Also, inflammatory and oxidative parameters were evaluated in gastrocnemius muscle and the creatine kinase (CK) activity and lactate/glicose levels in rat’s serum and plasma, resp. Muscle injury caused mech. and cold allodynia, and increased nociceptive scores, without inducing locomotor impairment. This model also increased the inflammatory cells infiltration (seen by myeloperoxidase and N-acetyl-β-D-glucosaminidase activities and histol. procedure), nitric oxide, interleukin (IL)-1β, IL-6, and dichlorofluorescein fluorescence in muscle samples; and CK activity and lactate/glicose ratio. The treatment with 1% monosodium diclofenac reduced inflammatory cells infiltration, dichlorofluorescein fluorescence and lactate/glicose levels. Thus, we characterised the traumatic muscle injury as a reproducible model of muscle pain, which makes it possible to evaluate promising antinociceptive and anti-inflammatory therapies. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0COA of Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.COA of Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

2-Acyl-3-aminobenzofurans. II. Synthesis of heterocyclic systems consisting of 2-acyl-3-aminobenzofuran derivatives was written by Trofimov, F. A.;Shevchenko, L. I.;Lelyak, G. F.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.COA of Formula: C9H8N2O2 This article mentions the following:

Cyclization of I (R = Ac, R1 = OH) by Ac2O gave 87% benzofurooxazine II; cyclization by PhNH2 gave 54% III (R = Me, R1 = Ph). Treatment of I (R = H, R1 = OMe) with CH(OEt)3 gave 15% III (R = R1 = H); treatment with O-methylcaprolactam gave 35% III [RR1 = (CH2)5]. Treatment of I (R = ClCH2CO, R1 = Ph) with urotropine gave IV. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7COA of Formula: C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Condensation-cyclodehydration of 2,4-dioxobutanoates: synthesis of new esters of pyrazoles and isoxazoles and their antimicrobial screening was written by Siddiqui, Naqui Jahan;Idrees, Mohammad. And the article was included in Pharma Chemica in 2014.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Series of pyrazole-3-carboxylates I (X = NH, H₂NCON; R¹ = R³ = H, R² = Br; R¹ = Me, R² = Cl, R³ = H, Cl; R⁴ = Me) and isoxazole-3-carboxylates I (X = O; R¹ – R³ as above; R⁴ = Et) were synthesized by the reaction of 4-(benzofuran-2-yl)-2,4-dioxobutanoates II with active nitrogen nucleophiles (hydrazine hydrate, hydroxylamine hydrochloride or semicarbazide hydrochloride) via condensation-cyclodehydration sequence. The synthesized compounds I were evaluated for their antimicrobial activity against Gram pos. and Gram neg. bacteria and fungi. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An easy to make Hg(II) complex as a selective and sensitive fluorescent turn-on chemosensor for iodide in an aqueous solution based on metal ion displacement mechanism was written by Satheeshkumar, K.;Saravana Kumar, P.;Shanmugapriya, R.;Nandhini, C.;Vennila, K. N.;Elango, Kuppanagounder P.. And the article was included in Inorganic Chemistry Communications in 2022.Product Details of 54802-10-7 This article mentions the following:

A simple Schiff base ligand (L) bearing 3,5-dibromo-2-hyrdoxybenzaldehyde fluorophore moiety has rationally been designed, synthesized and characterized. The Hg(II) complex of L was synthesized by simply stirring a mixture of L and HgCl₂ in ethanol at RT and the resultant non-fluorescent complex HgL is found to detect iodide ion selectively, with a turn-on fluorescence in H₂O:DMSO (1:1 volume/volume) medium. The detection of iodide was performed via the metal ion displacement mechanism with a 1:2 (Probe:Iodide) stoichiometry and binding constant of 1.51 × 10⁴ M^-1. Novel HgL complex showed rapid response towards iodide ion with a limit of detection (LOD) as low as 60 nM. Moreover, the sensing mechanism of iodide by the complex is theor. supported by d. functional theory (DFT) and time dependent d. functional theory (TD-DFT) calculations In addition, estimation of iodide in real water samples, table salt and urine sample demonstrate the practical value of the probe. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-Droplet Electrophoretic Separation and Enrichment of Biomolecules was written by Saucedo-Espinosa, Mario A.;Dittrich, Petra S.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.Related Products of 76-54-0 This article mentions the following:

The authors demonstrate the in-droplet separation and enrichment of mols. from small organic mols. to long nucleic acids (lambda DNA). Elec. potentials are applied via two parallel three-dimensional electrodes, which interface the nanodroplets through polydimethylsiloxane (PDMS)-carbon composite membranes. These membranes enable the generation of uniform elec. fields inside the droplets, while simultaneously preventing the formation of electrolytic byproducts. Biomols. of different sizes migrate toward one side of the droplets, according to their net charge, when exposed to the elec. field. Directly afterward, a Y-junction promotes droplet splitting, resulting in the generation of biomol.-enriched daughter droplets. Biomols. were fluorescently labeled, and fluorescence microscopy was employed to assess their electrophoretic separation and enrichment. Exptl. results demonstrate how the enrichment of biomols. is influenced by their size, charge, and concentration, by the ionic strength, viscosity, and pH of the suspending medium, and by the in-droplet flow profile. Enrichments above 95% were observed for small mols. and highly charged species at velocities over 10 mm/s (13 droplets per s). Moreover, the enrichment performance asymptotically approached a value of 38% for velocities as high as 50 mm/s, demonstrating the potential of this technique for the high-throughput separation of charged species. The applicability of the system was demonstrated by cleaving a peptide and selectively separating the cleaved fragments in different daughter droplets on the basis of their net charge. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nicotinamide ameliorates amyloid beta-induced oxidative stress-mediated neuroinflammation and neurodegeneration in adult mouse brain was written by Rehman, Inayat Ur;Ahmad, Riaz;Khan, Ibrahim;Lee, Hyeon Jin;Park, Jungsung;Ullah, Rahat;Choi, Myeong Jun;Kang, Hee Young;Kim, Myeong Ok. And the article was included in Biomedicines in 2021.Formula: C20H10Cl2O5 This article mentions the following:

Alzheimer’s disease (AD) is the most predominant age-related neurodegenerative disease, pathol. characterized by the accumulation of aggregates of amyloid beta Aβ1-42 and tau hyperphosphorylation in the brain. It is considered to be the primary cause of cognitive dysfunction. The aggregation of Aβ1-42 leads to neuronal inflammation and apoptosis. Since vitamins are basic dietary nutrients that organisms need for their growth, survival, and other metabolic functions, in this study, the underlying neuroprotective mechanism of nicotinamide (NAM) Vitamin B3 against Aβ1-42 -induced neurotoxicity was investigated in mouse brains. Intracerebroventricular (i.c.v.) Aβ1-42 injection elicited neuronal dysfunctions that led to memory impairment and neurodegeneration in mouse brains. After 24 h after Aβ1-42 injection, the mice were treated with NAM (250 mg/kg i.p.) for 1 wk. For biochem. and Western blot studies, the mice were directly sacrificed, while for confocal and “immunohistochem. staining”, mice were perfused transcardially with 4% paraformaldehyde. Our biochem., immunofluorescence, and immunohistochem. results showed that NAM can ameliorate neuronal inflammation and apoptosis by reducing oxidative stress through lowering malondialdehyde and 2,7-dichlorofluorescein levels in an Aβ1-42-injected mouse brains, where the regulation of p-JNK further regulated inflammatory marker proteins (TNF-α, IL-1β, transcription factor NF-kB) and apoptotic marker proteins (Bax, caspase 3, PARP1). Furthermore, NAM + Aβ treatment for 1 wk increased the amount of survival neurons and reduced neuronal cell death in Nissl staining. We also analyzed memory dysfunction via behavioral studies and the anal. showed that NAM could prevent Aβ1-42 -induced memory deficits. Collectively, the results of this study suggest that NAM may be a potential preventive and therapeutic candidate for Aβ1-42 -induced reactive oxygen species (ROS)-mediated neuroinflammation, neurodegeneration, and neurotoxicity in an adult mouse model. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem