Synthesis, characterization and biological activities of some benzofuropyrimidine derivatives was written by Yamuna, A. J.;Vaidya, Vijayvithal P.;Shruthi, Eshwarappa;Mahadevan, Kittappa M.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2013.COA of Formula: C11H10BrNO3 This article mentions the following:
A series of new benzofuropyrimidinone derivatives I [Ar = C6H5, 2-ClC6H4, 4-ClC6H4, etc.; R = H, Me] were synthesized by using Et 3-amino-5-bromo-benzofuran-2-carboxylate (II) as a starting material. Amino ester II was converted into its hydrazide by reacting with hydrazine hydrate, which upon treatment with various aldehydes and ketones gave corresponding Schiff bases III [Ar = C6H5, 2-ClC6H4, 4-ClC6H4, etc.; R = H, Me]. The desired compounds I were obtained by reacting Schiff bases III with tri-Et orthoformate. The compounds I were evaluated for their antimicrobial activity by cup plate method and antioxidant activity by DPPH radical scavenging method. Some of the compounds exhibited considerable antimicrobial activities and compounds I [R = 4-MeOC6H4, 4-HOC6H4] were found to be excellent in scavenging DPPH radical at 50 μg and also retained almost same activity in 100 μg. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-5-bromobenzofuran-2-carboxylate (cas: 330555-71-0COA of Formula: C11H10BrNO3).
Ethyl 3-amino-5-bromobenzofuran-2-carboxylate (cas: 330555-71-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C11H10BrNO3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem