The influence of green tea extract on nintedanib’s bioavailability in patients with pulmonary fibrosis was written by Veerman, G. D. Marijn;van der Werff, Sanne C.;Koolen, Stijn L. W.;Miedema, Jelle R.;Oomen-de Hoop, Esther;van der Mark, Sophie C.;Chandoesing, Prewesh P.;de Bruijn, Peter;Wijsenbeek, Marlies S.;Mathijssen, Ron H. J.. And the article was included in Biomedicine & Pharmacotherapy in 2022.Recommanded Product: 24280-93-1 This article mentions the following:
Nintedanib is an oral small-mol. kinase inhibitor and first-line treatment for idiopathic pulmonary fibrosis. Nintedanib is a substrate of the drug efflux transporter ABCB1. Green tea flavonoids –especially epigallocatechin gallate (EGCG)– are potent ABCB1 modulators. We investigated if concomitant administration of green tea extract (GTE) could result in a clin. relevant herb-drug interaction. Patients were randomized between A-B and B-A, with A being nintedanib alone and B nintedanib with GTE. Both periods lasted 7 days, in which nintedanib was administered twice daily directly after a meal. In period B, patients addnl. received capsules with GTE (500 mg BID, >60% EGCG). Pharmacokinetic sampling for 12 h was performed at day 7 of each period. Primary endpoint was change in geometric mean for the area under the curve (AUC0-12 h). A linear mixed model was used to analyze AUCs and maximal concentration (Cmax). In 26 included patients, the nintedanib AUC0-12 h was 21% lower (95% CI -29% to -12%; P < 0.001) in period B (with GTE) compared to period A. Cmax did not differ significantly between periods; – 14% (95% CI -29% to +4%; P = 0.12). The detrimental effect was predominant in patients with the ABCB1 3435 C>T wild type variant. No differences in toxicities were observed Exposure to nintedanib decreased with 21% when administered 60 min after GTC for only 7 days. This is a statistically significant interaction which could potentially impair treatment efficacy. Before patients and physicians should definitely be warned to avoid this combination, prospective clin. validation of an exposure-response relationship is necessary. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Recommanded Product: 24280-93-1).
(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 24280-93-1
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem