Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1260795-42-3, is researched, SMILESS is O=C(C1C(C=O)=CC(Br)=CC=1)OC, Molecular C9H7BrO3Journal, Article, Chemistry – A European Journal called Indium-Catalyzed C-F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins, Author is Yata, Tetsuji; Nishimoto, Yoshihiro; Chiba, Kouji; Yasuda, Makoto, the main research direction is difluorovinyl benzoate indium oxymetalation fluorine elimination catalyst; isocoumarin fluorinated preparation; C−F bond transformation; catalysis; fluorinated heterocycles; gem-difluoroalkene; indium.Synthetic Route of C9H7BrO3.
Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochem. industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C-F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins, I (R 1 = H, 5-Me, 6-Me, 8-Cl, etc.; R2 = H, n-Bu). The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theor. calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem