Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 4412-91-3, Name is 3-Furanmethanol, SMILES is OCC1=COC=C1, belongs to benzofurans compound. In a document, author is Liu, Kun, introduce the new discover, Application In Synthesis of 3-Furanmethanol.
Electrooxidation enables highly regioselective dearomative annulation of indole and benzofuran derivatives
The dearomatization of arenes represents a powerful synthetic methodology to provide three-dimensional chemicals of high added value. Here we report a general and practical protocol for regioselective dearomative annulation of indole and benzofuran derivatives in an electrochemical way. Under undivided electrolytic conditions, a series of highly functionalized five to eight-membered heterocycle-2,3-fused indolines and dihydrobenzofurans, which are typically unattainable under thermal conditions, can be successfully accessed in high yield with excellent regio- and stereo-selectivity. This transformation can also tolerate a wide range of functional groups and achieve good efficiency in large-scale synthesis under oxidant-free conditions. In addition, cyclic voltammetry, electron paramagnetic resonance (EPR) and kinetic studies indicate that the dehydrogenative dearomatization annulations arise from the anodic oxidation of indole into indole radical cation, and this process is the rate-determining step.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4412-91-3 is helpful to your research. Application In Synthesis of 3-Furanmethanol.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem