334022-87-6, In an article, published in an article,authors is Borza, Istvan, once mentioned the application of 334022-87-6, Name is 6-Hydroxybenzofuran-2-carboxylic acid,molecular formula is C9H6O4, is a conventional compound. this article was the specific content is as follows.
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides
(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structure-activity relationship (SAR) and to attempt the improvement of the ADME properties of the lead, a series of compounds were prepared and tested. Several derivatives showed low nanomolar activity both in the binding and in the functional assay. In a formalin-induced hyperalgesia model in mice, 6a and (4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimidazol-2- yl]-methanone (60a) were as active as besonprodil (2) after oral administration. A CoMS1A model was developed based on binding data of a series of indole- and benzimidazole-2-carboxamides.
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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2889O – PubChem