Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, in an article , author is Zhao, Chao, once mentioned of 174775-48-5, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibiting DYRK1A. Eight isopentenyl-substituted compounds (1-8), including four coumarins (1-4), one benzofuran (5), and three flavonoids (6-8), were isolated and identified from G. uralensis Fisch. Among them, licocoumarone (LC, 5) showed effective inhibitory activity against DYRK1A with an IC50 value of 12.56 mu M. Molecular docking analysis suggested that LC completely occupied the whole pocket of DYRK1A and formed obvious hydrophobic interactions and hydrogen bonds with DYRK1A residues. Further in vitro validation, including Microscale Thermophoresis (MST) and drug affinity responsive target stability (DARTS) techniques, demonstrated the specific combining capacity of LC to DYRK1A. Meanwhile, LC induced significant cytotoxicity against DYRK1A-overexpressing BxPC-3 cells with an IC50 value of 50.77 mu M. Mechanism studies revealed that LC reduced c-MET protein level by inhibiting DYRK1A. These findings provide preliminary evidences that LC as a natural DYRK1A inhibitor suppresses human pancreatic adenocarcinoma BxPC-3 cell proliferation and induces cell apoptotic, which might present new options and possibilities for targeted therapies in pancreatic cancer therapy.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Meyer-Alert, Henriette, once mentioned the application of 6296-53-3, Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, molecular weight is 205.1669, MDL number is MFCD00453138, category is benzofurans. Now introduce a scientific discovery about this category.

Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio)

Biotests like the fish embryo toxicity test have become increasingly popular in risk assessment and evaluation of chemicals found in the environment. The large range of possible endpoints is a big advantage when researching on the mode of action of a certain substance. Here, we utilized the frequently used model organism zebrafish (Danio rerio) to examine regulative mechanisms in the pathway of the aryl-hydrocarbon receptor (AHR) in early development. We exposed embryos to representatives of two chemical classes known to elicit dioxin-like activity: benzo[a]pyrene for polycyclic aromatic hydrocarbons (PAHs) and 2,3-benzofuran for polar O-substituted heterocycles as a member of heterocyclic compounds in general (N-, S-, O-heterocycles; NSO-hets). We measured gene transcription of the induced P450 cytochromes (cyp1), their formation of protein and biotransformation activity throughout the whole embryonic development until 5 days after fertilization. The results show a very specific time course of transcription depending on the chemical properties (e.g. halogenation, planarity, K-ow), the physical decay and the biodegradability of the tested compound. However, although this temporal pattern was not precisely transferable onto the protein level, significant regulation in enzymatic activity over time could be detected. We conclude, that a careful choice of time and end point as well as consideration of the chemical properties of a substance are fairly important when planning, conducting and especially evaluating biotests.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3. In an article, author is Sun, Zhi-Gang,once mentioned of 174775-48-5.

The Research Progress of Direct Thrombin Inhibitors

Blood coagulation is the process of changing the blood from the flowing state to the gel state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated, and finally thrombin is formed to form fibrin clot. Direct thrombin inhibitors are important anticoagulant drug. These drugs can selectively bind to the active site of thrombin, inhibit thrombin activity, have strong action and high specificity, and have important significance in the clinical treatment of thrombus diseases. Some of them come from natural products of animals or plants, and many of them have been applied in the clinic. The other part is derived from the design, synthesis and activity studies of small molecule inhibitors. This review discusses the progress of direct thrombin inhibitors in recent years.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Electric Literature of 6296-53-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a article, author is Adeyemi, Ahmed, introduce new discover of the category.

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction

The palladium(0)-catalyzed intramolecular annulation of 12 1,3-disubstituted cyclopentenes, derived from (+)-vincelactam, resulted in 5-exo cyclizations which furnished a series of 2,5-dimethyl-14(3R,4’S)-2H-spiro[benzofuran-3,1′-cyclopentan]2′-en-4′-yl)-1H-pyrroles in excellent diastereoselectivities and useful isolated yields. The double bond migration process that followed the arylpalladium insertion was controlled by a fine-tuning of the reaction system, which provided regioselectivities of up to 98:2. The selective Mizoroki-Heck reaction was used as the key transformation for preparing two new spirocyclic monoprotected amino acids as single stereoisomers.

Electric Literature of 6296-53-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 6296-53-3 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, in an article , author is Ida, Hiroto, once mentioned of 6296-53-3, Recommanded Product: 6296-53-3.

Online fast pyrolysis of cellulose over titanium dioxide using tandem micro -reactor -GC -MS

In this work, the catalytic effect of titanium dioxide (TiO 2 ) on the online fast pyrolysis of cellulose was inves- tigated using a tandem micro reactor coupled to a gas chromatograph-mass spectrometer (GC -MS) system. This system was used in the following two different modes: in -situ and ex -situ . The results obtained with TiO 2 were compared with those of zeolite (HZSM-5) under identical pyrolysis conditions. Levoglucosan was the major product in the non -catalytic pyrolysis of cellulose. As for the catalytic pyrolysis of cellulose at 500 ? C with TiO 2 ( in -situ ), the peak of levoglucosan disappeared whereas aromatic hydrocarbons such as benzene, toluene and naphthalene were newly detected. In this case, oxygenated compounds such as furfural, furan, methylfuran were still observed for TiO 2 whereas oxygenated compounds (i.e, furan, benzofuran, methylbenzofuran, acetone and 2-butanone) with low yields were observed for in -situ catalytic pyrolysis with HZSM-5. For ex -situ catalytic py- rolysis of cellulose at 500 ? C using TiO 2 , oxygen -containing compounds were hardly formed, while various ar- omatic hydrocarbons were detected. When the ex -situ pyrolysis of cellulose with HZSM-5 was carried out, the yields of the aromatic hydrocarbons were comparable to those with TiO 2 .

Interested yet? Read on for other articles about 6296-53-3, you can contact me at any time and look forward to more communication. Recommanded Product: 6296-53-3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application of 6296-53-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a article, author is Ali, T. E., introduce new discover of the category.

Nucleophilic Reactivity of a Novel 3-Chloro-3-(4,9-dimethoxy5-oxo-5H-furo[3,2-g]chromen-6-yl)prop-2-enal

A novel 3-chloro-3-(4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromen-6-yl)prop-2-enal was synthesized from 6-acetyl-4,9-dimethoxy-5H-furo[3,2-g]chromen-5-one by the Vilsmeier-Haack reaction, and its chemical reactivity toward some mono- and di-nitrogen nucleophiles was investigated. The reactions of the synthesized enal with primary amines, specifically benzylamine andp-toluidine, gave novel enamines or enaminones, depending on the molar ratio of the reagents, and its reactions with 1,2- and 1,3-dinucleophiles produced some novel benzofuran derivatives bearing bipyrazole, pyrazolylisoxazole, and bipyrimidine substituents in the C(6)position. The structures of the newly synthesized compounds waere elucidated on the basis of their analytical and spectral data.

Application of 6296-53-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 6296-53-3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, belongs to benzofurans compound, is a common compound. In a patnet, author is Phan, Phuong-Thuy T., once mentioned the new application about 6296-53-3, COA of Formula: C10H7NO4.

Synthesis and anti-methicillin-resistant Staphylococcus aureus activity of 5,7-dibromo-2-benzoylbenzofurans alone and in combination with antibiotics

A series of 5,7-dibromo-2-benzoylbenzofurans were synthesized by the Rap-Stoermer condensation of 5,7-dibromosalicylaldehyde with diverse phenacyl bromides and evaluated for in-vitro antibacterial activities against methicillin-sensitive Staphylococcus aureus (MSSA) ATCC 29213, methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, and MRSA ATCC 33591 by agar dilution method. The synergistic effects were determined by using the agar dilution checkerboard assay. The derivatives bearing carboxylic acid functional groups exhibited reasonable activity against MRSA strains with the best MIC = 32 mu g/mL (9b, 9d). Moreover, the additive or synergistic interactions against MRSA strains was observed in six combinations (1b + cefuroxime/gentamicin, 1c + ciprofloxacin/gentamicin, 9b + gentamicin, and 9c + ciprofloxacin) with the fractional inhibitory concentration index (FICI) values in the range of 0.375-1.0. Significantly, the MICs of these antibiotics were reduced 2-4-fold. The results of the MTT assay illustrated the low mammalian cell cytotoxicity of these potent compounds.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem