Tag: M.W:200-300

He, Meixia; Lehn, Jean-Marie published an article about the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6,SMILESS:O=S(C(F)(F)F)([O-])=O.[Ag+] ).Recommanded Product: Silver(I) trifluoromethanesulfonate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2923-28-6) through the article.

Optimizing C=N bond formation and C/N component exchange has major significance in dynamic covalent chem. (DCC). Imine and hydrazone generation from their aldehyde, amine and hydrazine components showed large accelerations in presence of AgOTf or Zn(OTf)2, up to 104 for the Zn(II)-(p-anisidine)imine complex. Zn(OTf)2 and auxiliary p-anisidine together accelerated 630 times the formation of the Zn(II)-hydrazone complex, revealing a strong synergistic effect, traced to very fast initial formation of the reactive Zn(II)-imine complex presenting a C=N bond metallo-activated towards reaction with the hydrazine component. Reactions involving more entities showed kinetically faster and thermodynamically simpler outputs due to dynamic competition within a mixture of higher complexity. Catalytic amounts of metal salts and auxiliary amine gave similar marked rate accelerations and turnover, indicating true catalysis. The synergistic effect achieved by combining metallo- and organo-catalysis points to a powerful co-catalysis strategy of bond-formation in DCC through interconnected chem. transformations.

Here is a brief introduction to this compound(2923-28-6)Recommanded Product: Silver(I) trifluoromethanesulfonate, if you want to know about other compounds related to this compound(2923-28-6), you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference：
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference：
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem