Properties and Exciting Facts About Benzofuran-2-carboxylic acid

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A variety of arylboronic esters were efficiently carboxylated with CO 2 using a simple AgOAc/PPh3 catalyst, affording the corresponding carboxylic acids in good yield. This simple and efficient silver(i) catalytic system showed wide functional group compatibility. The Royal Society of Chemistry 2012.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2046O – PubChem

The Absolute Best Science Experiment for 1563-38-8

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Reference of 1563-38-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, molecular formula is C10H12O2. In a Article,once mentioned of 1563-38-8

Global pollution from excessive pesticide use has become a serious environmental and public health problem. The aim of the study was to optimize the fungal mediated simultaneous removal of carbofuran and carbaryl from soil. Carb-PV5 strain was isolated from contaminated soil following enrichment culture technique; based on 18S rRNA sequencing, strain was identified as Acremonium sp. (MK514615); Field Emission Scanning Electron Microscopic analysis reflected its morphology. Towards the development of bioaugmentation strategy for the bioremediation of carbamate-contaminated soil, the process parameters were optimized employing Central Composite Rotatable Method. The experimental studies were performed in the range of biomass (0.2?0.6 g kg?1), temperature (23?33 C), pH (6?9) and moisture (10?30%). The degradation rate parameters, k and t1/2 were determined to as 0.475, 0.325 d?1 and 5.39, 2.1 d with the corresponding r2 of 0.9491, 0.9964 for zero and first order, respectively. The cube root growth kinetic constant k of Acremonium sp. varied from 0.0469 to 0.0512 (g1/3 L?1/3 h?1) and 0.0378 to 0.0415 (g1/3 L?1/3 h?1) for carbofuran and carbaryl, respectively. To confirm the model appropriacy and sustainability of the optimization procedure, bioremediation experiments were conducted onto real carbamate-contaminated soils. UPLC and GCMS analysis confirmed the successful removal of carbamates. The current study presents the first report on the bioaugmentation studies carried out on the mixed carbamate contaminated soil using newly isolated Acremonium sp.

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Benzofuran – Wikipedia,
Benzofuran | C8H2373O – PubChem

The Absolute Best Science Experiment for 2,3-Dihydrobenzofuran-7-amine

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Related Products of 13414-56-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13414-56-7, Name is 2,3-Dihydrobenzofuran-7-amine, molecular formula is C8H9NO. In a Article,once mentioned of 13414-56-7

Deregulated activity of the nonreceptor tyrosine kinase c-Src is believed to result in signal transduction, cytoskeletal and adhesion changes, ultimately promoting a tumor-invasive phenotype. We report here the discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of the c-Src enzyme. Special attention was directed toward finding inhibitors selective against KDR tyrosine kinase in order to ensure that the in vivo profile of a specific Src inhibitor could be determined. The 4-aminobenzodioxole quinazoline series gave compounds with excellent potency and selectivity. The most interesting compounds were evaluated in vivo and displayed good pharmacokinetics following oral dosing. Compounds such as the aminobenzodioxoles were shown to be potent inhibitors of tumor growth in a c-Src-transformed 3T3 xenograft model in vivo, resulting in more than 90% growth inhibition at doses as low as 6 mg/kg po once daily. Src tyrosine kinase inhibitors such as these may provide a novel therapeutic modality for targeting cancer invasion and metastasis.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H526O – PubChem

Brief introduction of Benzo[b]furan-2-carboxaldehyde

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The alkylmagnesium alkoxide sBuMgOR?LiOR (R=2-ethylhexyl), which was prepared as a 1.5 m solution in toluene, undergoes very fast Br/Mg exchange with aryl and heteroaryl bromides, producing aryl and heteroaryl magnesium alkoxides (ArMgOR?LiOR) in toluene. These Grignard reagents react with a broad range of electrophiles, including aldehydes, ketones, allyl bromides, acyl chlorides, epoxides, and aziridines, in good yields. Remarkably, the related reagent sBu2Mg?2 LiOR (R=2-ethylhexyl) undergoes Cl/Mg exchange with various electron-rich aryl chlorides in toluene, producing diorganomagnesium species of type Ar2Mg?2 LiOR, which react well with aldehydes and allyl bromides.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1140O – PubChem

Archives for Chemistry Experiments of 4265-16-1

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A series of 2-(arylmethyl)-3-substituted quinuclidines was developed as alpha7 neuronal nicotinic acetylcholine receptor (nAChR) agonists based on a putative pharmacophore model. The series is highly selective for the alpha7 over other nAChRs (e.g., the alpha4beta2 of the CNS, and the muscle and ganglionic subtypes) and is functionally tunable at alpha7. One member of the series, (+)-N-(1-azabicyclo[2.2.2]oct-3-yl)benzo[b]furan-2-carboxamide (+)-8l), has potent agonistic activity for the alpha7 nAChR (EC50 = 33 nM, Imax = 1.0), at concentrations below those that result in desensitization.

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Benzofuran – Wikipedia,
Benzofuran | C8H949O – PubChem

More research is needed about 3-Hydroxyisobenzofuran-1(3H)-one

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A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT2C agonism with excellent selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.

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Benzofuran – Wikipedia,
Benzofuran | C8H1454O – PubChem

Can You Really Do Chemisty Experiments About 35700-40-4

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Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-dihydrobenzofura n, are disclosed. These compounds are useful as imaging agents for D-2 receptors in the human brain and exhibit good brain retention and in vivo stability.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2181O – PubChem

Some scientific research about 4,5-Difluorophthalic Anhydride

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To improve the processability and thermal stability of polyimide, a series of novel phenylethynyl-endcapped oligoimides (PEPA-oligoimides) with calculated molecular weights (MnC) were successfully prepared from thermal imidization of 4,4?-(9-fluorenylidene) dianiline (BAFL) as fluorenyl diamine, 4,4?-oxy-diphthalic anhydride (ODPA) as aromatic dianhydride and 4-phenylethynylphthalic anhydride (4-PEPA) acted as reactive end-capping reagent at elevated temperatures. Experiment results indicated that the oligoimides were the mixtures of PEPA-endcapped oligomers with different degrees of polymerization characterized by MALDI-TOF mass spectra. The influence of chemical structures on the melt processabilities of the oligoimides, the thermal, dielectric and mechanical properties of the thermoset resins was studied. The typical oligoimide resin owned minimum melt viscosity of 0.2 Pa·s at around 310 C and wide melting processing window, suitable for resin transfer molding (RTM). Besides, its corresponding thermal-cured polyimide resin possessed glass transition temperature (Tg) as high as 514 C. The dielectric constants of polyimide resins decreased from 3.15 to 2.80 by reducing the MnC. The mechanical properties of the polyimide neat resins were improved gradually with increasing MnC. Finally, the carbon fiber/polyimide (Cf/PI) composite laminates showed excellent mechanical strength retention rate at 350 C, might be long-term served at extremely high temperature in aerospace and aviation field.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2922O – PubChem

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This review provides a summary of syntheses of galanthamine since 2006, the time of publication of the last major review on this topic. Some landmark syntheses that were reported prior to 2006 are mentioned here as well for completeness. A brief review of biosynthesis of galanthamine is also provided.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3261O – PubChem

Discovery of 2-Methylbenzofuran

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Substituted 2-methylbenzofurans were obtained from 2-allylphenols via Pd2+-catalyzed oxidative cyclization using Cu(OAc)2-LiCl as a reoxidant and wet DMF as a solvent.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H258O – PubChem