Tag: 400-500

Ligand Function of Ion-Selective Electrodes Reversible to Zinc and Cobalt Thiocyanate Complexes: Causes of Formation, Mathematical Description, and Analytical Applications was written by Matveichuk, Yu. V.;Rakhman’ko, E. M.. And the article was included in Journal of Analytical Chemistry in 2019.Application of 76-54-0 This article mentions the following:

The manifestation of the ligand function of Zn(NCS)₄^2- and Co(NCS)₄^2- selective electrodes based on higher quaternary ammonium salts is explained by the exchange displacement of zinc and cobalt thiocyanates by SCN^– ions from the membrane into the near-electrode layer of the solution Its action is limited by the dissociation of the quaternary ammonium salt as an associate with Zn(NCS)₄^2- and Co(NCS)₄^2- ions. The effect of the background concentration of CoCl₂ or ZnCl₂ on the selectivity of Zn(NCS)₄^2- and Co(NCS)₄^2- selective electrodes based on higher quaternary ammonium salts to SCN^– ions is studied. The introduction of CoCl₂ or ZnCl₂ into the solution binds cobalt or zinc ions released from the membrane into thiocyanate complexes. The high selectivity of the Zn(NCS)₄^2- and Co(NCS)₄^2-selective electrodes to SCN^– ions is due to the higher extraction ability of the cobalt and zinc complexes with SCN^– ions compared to acid complexes with the competing anions. It is demonstrated that Zn(NCS)₄^2- and Co(NCS)₄^2- selective electrodes can be used for the determination of SCN^– ions in process solutions in the production of polyacrylonitrile fibers. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Morroniside protects OLN-93 cells against H₂O₂-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities was written by Li, Fengzhi;Song, Xue;Xu, Jiaxin;Shi, Yujiao;Hu, Ruina;Ren, Zhen;Qi, Qi;Lu, Hezuo;Cheng, Xiaoxin;Hu, Jianguo. And the article was included in Cell Cycle in 2021.COA of Formula: C20H10Cl2O5 This article mentions the following:

Neurodegenerative disorders, including spinal cord injury (SCI), result in oxidative stress-induced cell damage. Morroniside (MR), a major active ingredient of the Chinese herb Shan Zhu Yu, has been shown to ameliorate oxidative stress and inflammatory response. Our previous study also confirmed that morroniside protects SK-N-SH cell line (human neuroblastoma cells) against oxidative impairment. However, it remains unclear whether MR also plays a protective role for oligodendrocytes that are damaged following SCI. The present study investigated the protective effects of MR against hydrogen peroxide (H₂O₂)-induced cell death in OLN-93 cells. MR protected OLN-93 cells from H₂O₂-induced injury, attenuated H₂O₂-induced increase in reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and blocked the reduction of mitochondrial membrane potential (MMP) induced by H₂O₂. MR enhanced the activity of the antioxidant enzyme superoxide dismutase (SOD) and suppressed H₂O₂-induced downregulation of the antiapoptotic protein Bcl-2 and activation of the proapoptotic protein caspase-3. Finally, we found that LY294002, a specific inhibitor of the PI3K/Akt pathway, inhibited the protective effect of MR against H₂O₂-induced OLN-93 cell injury in the MTT and TUNEL assays. LY294002 also inhibited the expression of SOD and Bcl-2, and increased the expression of iNOS and c-caspase-3 induced by MR treatment. MR exerts protective effects against H₂O₂-induced OLN-93 cell injury through the PI3K/Akt signaling pathway-mediated antioxidative stress and antiapoptotic activities. MR may provide a potential strategy for SCI treatment or other related neurodegeneration. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0COA of Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The budesonide-hydroxypropyl-beta-cyclodextrin complex attenuates ROS generation, IL-8 release and cell death induced by oxidant and inflammatory stress. Study on A549 and A-THP-1 cells was written by Bayiha, Jules Cesar;Evrard, Brigitte;Cataldo, Didier;De Tullio, Pascal;Mingeot-Leclercq, Marie-Paule. And the article was included in Molecules in 2020.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Synthetic glucocorticoids such as budesonide (BUD) are potent anti-inflammatory drugs commonly used to treat patients suffering from chronic inflammatory diseases. A previous animal study reported a higher anti-inflammatory activity with a 2-hydroxypropyl-β-cyclodextrin (HPβCD)-based formulation of BUD (BUD:HPβCD). This study investigated, on cellular models (A549 and A-THP-1), the effect of BUD:HPβD in comparison with BUD and HPβCD on the effects induced by oxidative and inflammatory stress as well as the role of cholesterol. We demonstrated the protective effect afforded by BUD:HPβCD against cytotoxicity and ROS generation induced by oxidative and inflammatory stress. The effect observed for BUD:HPβCD was comparable to that observed with HPβCD with no major effect of cholesterol content. We also demonstrated (i) the involvement of the canonical mol. pathway including ROS generation, a decrease in PI3K/Akt activation, and decrease in phosphorylated/unphosphorylated HDAC2 in the effect induced by BUD:HPβCD, (ii) the maintenance of IL-8 decrease with BUD:HPβCD, and (iii) the absence of improvement in glucocorticoid insensitivity with BUD:HPβCD in comparison with BUD, in conditions where HDAC2 was inhibited. Resulting from HPβCD antioxidant and anticytotoxic potential and protective capacity against ROS-induced PI3K/Akt signaling and HDAC2 inhibition, BUD:HPβCD might be more beneficial than BUD alone in a context of concomitant oxidative and inflammatory stress. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells was written by Pandit, Kritika;Kaur, Sandeep;Kumar, Ajay;Bhardwaj, Renu;Kaur, Satwinderjeet. And the article was included in Nutrition and Cancer in 2021.COA of Formula: C20H10Cl2O5 This article mentions the following:

Trans-Anethole, the major bioactive component of Illicium verum Hook. commonly known as star anise exhibits various pharmacol. activities including anti-inflammatory, antimicrobial, insecticidal, and antitumor. Osteosarcoma is an extremely aggressive malignant bone tumor that affects children and young adults and accounts for around 60% of all sarcomas. The study was planned to evaluate the potential of trans-Anethole against Human osteosarcoma cell line MG-63. The antiproliferative activity of trans-Anethole was assessed by MTT assay. trans-Anethole exhibited apoptotic cell death as monitored by confocal/electron microscopy and flow cytometry studies. Modulation of gene expression was studied by Western blot and RT-PCR anal. The present study revealed that trans-Anethole inhibited osteosarcoma proliferation in a dose-dependent manner with a GI50 value of 60.25μM and showed pro-apoptotic activity as analyzed by Annexin V-FITC/PI assay. Flow cytometric anal. revealed that trans-Anethole induced cell cycle arrest at the G0/G1 phase with the generation of reactive oxygen species and reduction in mitochondrial membrane potential (ΔΨm). Immunoblotting results showed the increased expression of caspase-9/-3, p53, and decreased expression of Bcl-xL suggesting the involvement of the p53 and mitochondrial intrinsic pathway. This work provides a rationale that trans-Anethole might be considered as a promising chemotherapeutic/nutraceutical agent for the management of osteosarcoma. Highlightstrans-Anethole inhibited cell growth and caused G0/G1 arrest in Human osteosarcoma MG-63 cell line.trans-Anethole led to the loss of mitochondrial membrane permeability along with ROS generation.trans-Anethole upregulates the expression of p53, Caspase-9/-3, and downregulate Bcl-xL expression. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0COA of Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease was written by Stankova, Pavla;Kucera, Otto;Peterova, Eva;Lotkova, Halka;Maseko, Tumisang Edward;Nozickova, Katerina;Cervinkova, Zuzana. And the article was included in International Journal of Molecular Sciences in 2020.Computed Properties of C20H10Cl2O5 This article mentions the following:

Maladaptation of mitochondrial oxidative flux seems to be a considerable feature of nonalcoholic fatty liver disease (NAFLD). The aim of this work was to induce NAFLD in mice fed a Western-style diet (WD) and to evaluate liver mitochondrial functions. Experiments were performed on male C57BL/6J mice fed with a control diet or a WD for 24 wk. Histol. changes in liver and adipose tissue as well as hepatic expression of fibrotic and inflammatory genes and proteins were evaluated. The mitochondrial respiration was assessed by high-resolution respirometry. Oxidative stress was evaluated by measuring lipoperoxidation, glutathione, and reactive oxygen species level. Feeding mice a WD induced adipose tissue inflammation and massive liver steatosis accompanied by mild inflammation and fibrosis. We found decreased succinate-activated mitochondrial respiration and decreased succinate dehydrogenase (SDH) activity in the mice fed a WD. The oxidative flux with other substrates was not affected. We observed increased ketogenic capacity, but no impact on the capacity for fatty acid oxidation We did not confirm the presence of oxidative stress. Mitochondria in this stage of the disease are adapted to increased substrate flux. However, inhibition of SDH can lead to the accumulation of succinate, an important signaling mol. associated with inflammation, fibrosis, and carcinogenesis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy was written by Zhou, Tian-Jiao;Xu, Yuan;Xing, Lei;Wang, Yi;Jiang, Hu-Lin. And the article was included in Advanced Materials (Weinheim, Germany) in 2021.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular hydrogen peroxide (H₂O₂) into hydroxyl radicals (OH·). Although many studies on H₂O₂ supplementation have been conducted to improve the therapeutic effect of CDT, few studies have focused on the application of superoxide radical (O₂^-·) in CDT, which may result in better efficacy. A major concern about O₂^-·-mediated CDT is its tendency to induce serious oxidative damage to normal tissues, which may be addressed by using a degradable O₂^-· scavenger. Here, a harmless-harmful switchable and uninterrupted laccase (LAC)-instructed killer (HULK) is constructed, which is the first CDT agent accelerated by LAC-instructed O₂^-· generation and possesses a harmless-harmful switchable effect because of the photodegradation of the O₂^-· scavenger iron-chlorin e6 (FeCe6). LAC-instructed substrate oxidation effectively catalyzes O₂-· production with the help of intracellular reduction, thereby promoting the conversion of Fe³⁺ to Fe²⁺, accelerating the generation of OH·, and inducing tumor cell apoptosis and necrosis. The introduced O₂-· scavenger FeCe6 is quickly photodegraded during irradiation, while LAC-instructed O₂^-· generation proceeds as before, resulting in activatable CDT. This work not only provides the first strategy for LAC-instructed O₂^-· generation but also presents new insight into activatable CDT. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cholinergic system and exploratory behavior are changed after weekly-binge ethanol exposure in zebrafish was written by Bernardo, Henrique Teza;Agostini, Jotele Fontana;Toe, Helena Cristina Zuehl Dal;Vieira, Karine Medeiros;Baldin, Samira Leila;Schuck, Patricia Fernanda;Uribe-Cruz, Carolina;Longo, Larisse;da Silveira, Themis Reverbel;Rosemberg, Denis Broock;Rico, Eduardo Pacheco. And the article was included in Pharmacology, Biochemistry and Behavior in 2019.Synthetic Route of C20H10Cl2O5 This article mentions the following:

Binge drinking is characterized by excessive alc. consumption in a short period of time and is associated with a poor quality of life. Zebrafish are commonly used to investigate neurochem., behavioral, and genetic parameters associated with ethanol (EtOH) exposure. However, few studies have used zebrafish as a model to investigate binge EtOH exposure. In order to elucidate the potential neurobehavioral impairments evoked by binge EtOH exposure in zebrafish, animals were immersed in 1.4% EtOH for 30 min three consecutive times with intervals of one week. Neurobehavioral parameters were analyzed immediately following the third exposure, as well as 2 and 9 days later. Brain choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were reduced 9 days after the treatment. Thiobarbituric acid-reactive species and dichlorodihydrofluorescein levels were increased immediately after the treatment, but both returned to normal levels 2 days after the treatment. Catalase and glutathione reductase were impaired 2 and 9 days after the treatment. No alteration was observed in superoxide dismutase and glutathione peroxidase activities. EtOH treatment did not alter brain expression of inflammatory genes such as il-1β, il-10, and tnf-α . Zebrafish displayed anxiolytic-like behavior immediately after the last exposure, though there was no behavioral alteration observed 9 days after the treatment. Therefore, binge EtOH exposure in zebrafish leads to long lasting brain cholinergic alteration, probably related to oxidative stress immediately after the exposure, which is independent of classical inflammatory markers. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Impaction of factors associated with oxidative stress on the pathogenesis of gestational hypertension and preeclampsia: A Chinese patients based study was written by Qiu, Dongmei;Wu, Jufei;Li, Min;Wang, Li;Zhu, Xianggan;Chen, Youguo. And the article was included in Medicine (Philadelphia, PA, United States) in 2021.Synthetic Route of C20H10Cl2O5 This article mentions the following:

We aimed to investigate the effect of Kelch-like ECH-associated protein 1/NF-E2 p45-related factor 2 (Keap1/Nrf2) pathway on the biol. function of trophoblast cells in oxidative stress model at the cellular level, and analyzed the expression level and clin. significance of Keap1/Nrf2 pathway and related antioxidant factors in placental tissues of Preeclampsia (PE) patients at clin. level. In present study, we found that under hypoxia/reoxygenation conditions, the activity of oxidative stress-related enzymes (CAT, GSH-Px, SOD) in HTR8/SVneo cells was significantly lower than that before treatment (P<01). The activities of CAT, GSH-Px and SOD in HTR8/SVneo cells in SiRNA+H/R group decreased significantly (P<01), indicating the important defense effect of Keap1/Nrf2 signaling pathway in oxidative stress. As a control group of Nrf2SiRNA+H/R group, Si-NC+H/R group had CAT, GSH-Px and SOD activities decreasing, which was similar to that in H/R group. Moreover, the activities of oxidative stress-related active enzymes in patients with PE were further confirmed by detecting and comparing the activities of CAT, GSH-Px and SOD in placental tissues. The results showed that the activity of SOD (P<001), GSH-Px (P<01) and CAT (P<01) in placental tissues of patients with PE were significant different from those of normal placental tissues. The expression level of Keap1 in placenta of patients with PE was slightly lower than that of normal placenta. While the expression of Nrf2 in placenta of patients with PE was significantly higher than that of normal placenta. HO-1 expression in placenta of patients with PE was significantly higher than that of normal placenta. These results implicate the importance of Keap-1/Nrf2 pathway in PE. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effects of operating conditions on PM oxidative potential assays was written by Frezzini, Maria Agostina;De Francesco, Nayma;Massimi, Lorenzo;Canepari, Silvia. And the article was included in Atmospheric Environment in 2022.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Oxidative potential (OP) has been suggested as a biol. relevant exposure metric for estimating particulate matter (PM) capacity to induce oxidative stress in living organisms. However, standardized exptl. procedures are not yet available. This study explores how a variety of operating conditions influences responses of several different assays for measuring OP: the 2′,7′-dichlorofluorescein (OP^DCFH), the ascorbic acid (OP^AA) and the dithiothreitol (OP^DTT) assays. A recently optimized method for the evaluation of PM reducing properties, based on the 2,2-diphenyl-1-picrylhydrazyl assay (RP^DPPH), was also included in the study. Two monitoring campaigns were carried out in Central Italy by using co-located PM10 samplers working in parallel, for comparing results obtained from different operating procedures simultaneously applied on equivalent samples. Extraction efficiency and repeatability of three different water-extraction methods (rotating agitator, ultrasonic bath, and vortex), and the influence of storage duration and conditions on OP results were examined OPDCFH values were found to be significantly higher when ultrasonic bath (US) was used for extraction, probably due to the formation of free radicals induced by US; for all the OP assays, the highest repeatability was obtained by extracting samples with rotating agitator (RA). Sample storage was confirmed to be a very critical issue as all the assays, except OP^DTT, showed a marked dependence on storage time and conditions. The influence of membrane filters used to collect PM was also assessed. No significant differences were observed between samples collected on quartz and polytetrafluoroethylene (PTFE) membrane filters, except for OP^AA, that gave significantly higher results for samples collected on PTFE membranes. Lastly, the contribution of water-insoluble PM components to OP was examined and warrants further investigations. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Anti-inflammatory potential of cultured ginseng roots extract in lipopolysaccharide-stimulated mouse macrophages and adipocytes was written by Park, Hyun Ju;Jo, Sang-Mi;Seo, Seok Hee;Lee, Myoungsook;Lee, Yunkyoung;Kang, Inhae. And the article was included in International Journal of Environmental Research and Public Health in 2020.Recommanded Product: 76-54-0 This article mentions the following:

Wild ginseng, Panax ginseng Meyer, is a traditional medicine widely used in Asia. Due to low reward and high costs, wild ginseng is produced by a plant cell culture technique called cultured ginseng roots (GR). The health benefits of wild ginseng have been well studied, but the potential health effects of GR are largely unknown. Thus, we investigated the role of a GR extract (GRE) on inflammatory responses. We firstly investigated the anti-inflammatory potential of GRE in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. GRE (100 Μg/mL) dampened pro-inflammatory gene expression, cytokine release, reactive oxygen species (ROS) production, and mitogen-activated protein kinase (MAPK) activation. These anti-inflammatory responses by GRE were confirmed in mouse bone marrow-derived macrophages (BMDMs), which showed that GRE could inhibit inflammation with the induction of antioxidant levels. LPS was recently reported to impair mitochondrial bioenergetics in mouse macrophages. We next measured the mitochondrial oxygen consumption rate (OCR), determining mitochondrial function. LPS treatment downregulated OCR; however, GRE partially restored the LPS-mediated energy homeostasis defects. Furthermore, GRE-pretreated conditioned media (CM) obtained from mouse macrophages decreased CM-mediated adipocyte inflammation. Collectively, these data suggested that GRE attenuated LPS-induced inflammation, and it might be partially involved in the protection from mitochondrial dysfunction in macrophages and adipocytes. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem