Tag: 400-500

Hepatoprotective potential of kirenol on ethanol-induced liver toxicity in albino rats and acetaminophen-induced oxidative stress-mediated apoptosis in hepatic HepG2 cells was written by Sun, Dongsheng;Li, Ying;Cao, Hui;Guo, Hui;Alahmadi, Tahani Awad;Alharbi, Sulaiman Ali;Yu, Jian. And the article was included in Journal of Biochemical and Molecular Toxicology in 2021.Recommanded Product: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Liver diseases are a major health issue in both men and women and cause significant mortality worldwide. The hepatoprotective effects of kirenol were evaluated in acetaminophen (APAP)-induced toxicity in HepG2 cells and ethanol (EtOH)- induced hepatotoxicity in rats. The cytotoxicity of kirenol (IC₅₀, 25 ν M/mL) and APAP (20μ g/mL) with sylimarin (IC₅₀, 15μg/mL) was observed in HepG2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Furthermore, reactive oxygen species formation, mitochondrial membrane potential, and oxidative stress markers such as thiobarbituric acid-reactive substance, suproxide dismutase, and catalase were assayed. Rats were administered a different dose (10, 20, and 30 mg/kg/day) for a period of 4 wk before a single dose of EtOH (40% vol/vol) 3 g/kg/day. EtOH administered rats appeared to have lower body weight gain, severe hepatic and kidney damage as proved by elevated aspartate transaminase, alanine transaminase, alk. phosphatase, uric acid, increased malondialdehyde (MDA), and inflammatory markers, and reduced glutathione (GSH) levels. Results showed that the kirenol treatment enhanced the GSH and reduced MDA in the liver and renal tissues and restored TNF-α and IL-6. Histoanal. proved the protective effects of kirenol. In conclusion, it was proved that the kirenol demonstrated a hepato-protective effect in APAP- and EtOH-induced liver toxicity in HepG2 cells and rats, resp. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Optimization of analytical assay performance of antibody-gated indicator-releasing mesoporous silica particles was written by Costa, Elena;Climent, Estela;Gawlitza, Kornelia;Wan, Wei;Weller, Michael G.;Rurack, Knut. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2020.COA of Formula: C20H10Cl2O5 This article mentions the following:

Antibody-gated indicator delivery (gAID) systems based on mesoporous silica nano- and microparticle scaffolds are a promising class of materials for the sensitive chem. detection of small-mol. analytes in simple test formats such as lateral flow assays (LFAs) or microfluidic chips. Their architecture is reminiscent of drug delivery systems, only that reporter mols. instead of drugs are stored in the voids of a porous host particle. In addition, the pores are closed with macromol. “caps” through a tailored “gatekeeping” recognition chem. so that the caps are opened when an analyte has reacted with a “gatekeeper”. The subsequent uncapping leads to a release of a large number of indicator mols., endowing the system with signal amplification features. Particular benefits of such systems are their modularity and adaptability. With the example of the immunochem. detection of type-I pyrethroids by fluorescent dye-releasing gAID systems, the influence of several tuning modes on the optimization of such hybrid sensory materials is introduced here. In particular, different mesoporous silica supports (from nano- and microparticles to platelets and short fibers), different functionalization routes and different loading sequences were assessed. The materials′ performances were evaluated by studying their temporal response behavior and detection sensitivity, including the tightness of pore closure (through the amount of blank release in the absence of analyte) and the release kinetics. The authors′ results indicate that the better the paratope-accommodating Fab region of the antibody “cap” fits into the host material′s pore opening, the better the closing/opening mechanism can be controlled. Because such materials are well-suited for LFAs, performance assessment included a test-strip format besides conventional assays in suspension. In combination with dyes as indicators and smartphones for read-out, simple anal. tests for use by untrained personnel directly at a point-of-need such as an aeroplane cabin can be devised, allowing for sensitivities down to the μg kg^-1 range in <5 min with case-required selectivities. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0COA of Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

NIR-II-driven intracellular photocatalytic oxygen-generation on Z-Scheme iron sulfide/cobalt sulfide nanosheets for hypoxic tumor therapy was written by Wang, Limin;Kang, Keke;Hou, Huaying;Ma, Yajie;Yu, Kai;Qu, Fengyu;Lin, Huiming. And the article was included in Journal of Colloid and Interface Science in 2022.HPLC of Formula: 76-54-0 This article mentions the following:

Tumor hypoxia not only promotes the proliferation, invasion and metastasis of cancer cells but also seriously hinders photodynamic therapy (PDT). Here, second near-IR (NIR-II) photocatalytic O₂ generation is introduced to relieve hypoxia. FeS₂/CoS₂@PEG (FCs@PEG) nanosheets (∼80 nm) are prepared with Fe-Co layered double hydroxides (LDHs) as precursor. As-synthesized samples have great NIR-II harvest and photothermal conversion efficiency (50.5%, 1064 nm). In addition, photothermal effect can elevate the thermal energy of nanocomposite to supply extra energy and to excite FeS₂ (1.16 eV) and CoS₂ (1.37 eV) simultaneously by low-energy NIR-II (1064 nm, 1.16 eV) irradiation Band structure is further investigated to discover the Z-Scheme mechanism of FCs@PEG, whose photogenerated charges remains high redox potential to oxidize water forming O₂ and to capture O₂ producing reactive oxygen species (ROS), resp. In addition, FC₂@PEG enhances peroxidase and catalase activities attributing to the lower resistance for charge transfer in heterostructure. Besides, the nanocomposite also can be used as glutathione oxidase (GSHOD) to deplete GSH and break intracellular redox balance, facilitating oxidative stress. Most importantly, FC₂@PEG reveals excellent biodegradation and elimination via feces and urine within 14 D. FCs@PEG integrate magnetic resonance and photothermal imaging (MRI and PTI), O₂ in situ supply, and synergistic photothermal therapy (PTT)/PDT/chemotherapy (CDT) to arouse immune response for anticancer. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem