Tag: 400-500

Photoluminescence enhancement of organic dye by graphene quantum dots was written by Sagar, Vijay Kumar;Veluthandath, Aneesh V.;Bisht, Prem Ballabh. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Computed Properties of C20H10Cl2O5 This article mentions the following:

The charge transfer (CT) interaction between the blue emitting graphene quantum dots (GQDs) and an organic dye (fluorescein 27, F27) has been first studied by steady-state and time-resolved spectroscopy as a function of the pH. F27 exists in the form of different inherent fluorescent species depending on the pH of the solvent. At pH 7, the CT interaction of GQDs with F27 results in a small red shift in the absorption and fluorescence spectra of the dye. The results indicate formation of a weak van der Waals (vdW) complex in the ground state. The photoluminescence decay rate of the GQDs is generally unaffected in the mixture indicating the absence of dynamic quenching. The fluorescence intensity of F27-GQD system shows a 3-fold increase. Numerical simulations reveal that apart from the CT interaction, hotspots in the nearfield of the GQDs contribute to the fluorescence enhancement. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

P27 protects neurons from ischemic damage by suppressing oxidative stress and increasing autophagy in the hippocampus was written by Kim, Woosuk;Kwon, Hyun Jung;Jung, Hyo Young;Hahn, Kyu Ri;Yoon, Yeo Sung;Hwang, In Koo;Choi, Soo Young;Kim, Dae Won. And the article was included in International Journal of Molecular Sciences in 2020.Recommanded Product: 76-54-0 This article mentions the following:

The P27Kip1 (p27), a well-known cell regulator, is involved in the regulation of cell death and survival. In the present study, we observed the effects of p27 against oxidative stress induced by H₂O₂in HT22 cells and transient ischemia in gerbils. Tat (trans-acting activator of transcription) peptide and p27 fusion proteins were prepared to facilitate delivery into cells and across the blood-brain barrier. The tat-p27 fusion protein, rather than its control protein Control-p27, was delivered intracellularly in a concentration and incubation time-dependent manner and showed its activity in HT22 cells. The localization of the delivered Tat-p27 protein was also confirmted in the HT22 cells and hippocampus in gerbils. In addition, the optimal concentration (5μ M) of Tat-p27 was determined to protect neurons from cell death induced by 1 mM H₂O₂. Treatment with 5μ M Tat-p27 significantly ameliorated H₂O₂-induced DNA fragmentation and the formation of reactive oxygen species (ROS) in HT22 cells. Tat-p27 significantly mitigated the increase in locomotor activity a day after ischemia and neuronal damage in the hippocampal CA1 region. It also reduced the ischemia-induced membrane phospholipids and ROS formation. In addition, Tat-p27 significantly increased microtubule-associated protein 1A/1B light chain 3A/3B expression and ameliorated the H₂O₂ or ischemia-induced increases of p62 and decreases of beclin-1 in the HT22 cells and hippocampus. These results suggest that Tat-p27 protects neurons from oxidative or ischemic damage by reducing ROS-induced damage and by facilitating the formation of autophagosomes in hippocampal cells. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nicotinamide ameliorates amyloid beta-induced oxidative stress-mediated neuroinflammation and neurodegeneration in adult mouse brain was written by Rehman, Inayat Ur;Ahmad, Riaz;Khan, Ibrahim;Lee, Hyeon Jin;Park, Jungsung;Ullah, Rahat;Choi, Myeong Jun;Kang, Hee Young;Kim, Myeong Ok. And the article was included in Biomedicines in 2021.Formula: C20H10Cl2O5 This article mentions the following:

Alzheimer’s disease (AD) is the most predominant age-related neurodegenerative disease, pathol. characterized by the accumulation of aggregates of amyloid beta Aβ1-42 and tau hyperphosphorylation in the brain. It is considered to be the primary cause of cognitive dysfunction. The aggregation of Aβ1-42 leads to neuronal inflammation and apoptosis. Since vitamins are basic dietary nutrients that organisms need for their growth, survival, and other metabolic functions, in this study, the underlying neuroprotective mechanism of nicotinamide (NAM) Vitamin B3 against Aβ1-42 -induced neurotoxicity was investigated in mouse brains. Intracerebroventricular (i.c.v.) Aβ1-42 injection elicited neuronal dysfunctions that led to memory impairment and neurodegeneration in mouse brains. After 24 h after Aβ1-42 injection, the mice were treated with NAM (250 mg/kg i.p.) for 1 wk. For biochem. and Western blot studies, the mice were directly sacrificed, while for confocal and “immunohistochem. staining”, mice were perfused transcardially with 4% paraformaldehyde. Our biochem., immunofluorescence, and immunohistochem. results showed that NAM can ameliorate neuronal inflammation and apoptosis by reducing oxidative stress through lowering malondialdehyde and 2,7-dichlorofluorescein levels in an Aβ1-42-injected mouse brains, where the regulation of p-JNK further regulated inflammatory marker proteins (TNF-α, IL-1β, transcription factor NF-kB) and apoptotic marker proteins (Bax, caspase 3, PARP1). Furthermore, NAM + Aβ treatment for 1 wk increased the amount of survival neurons and reduced neuronal cell death in Nissl staining. We also analyzed memory dysfunction via behavioral studies and the anal. showed that NAM could prevent Aβ1-42 -induced memory deficits. Collectively, the results of this study suggest that NAM may be a potential preventive and therapeutic candidate for Aβ1-42 -induced reactive oxygen species (ROS)-mediated neuroinflammation, neurodegeneration, and neurotoxicity in an adult mouse model. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-Droplet Electrophoretic Separation and Enrichment of Biomolecules was written by Saucedo-Espinosa, Mario A.;Dittrich, Petra S.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.Related Products of 76-54-0 This article mentions the following:

The authors demonstrate the in-droplet separation and enrichment of mols. from small organic mols. to long nucleic acids (lambda DNA). Elec. potentials are applied via two parallel three-dimensional electrodes, which interface the nanodroplets through polydimethylsiloxane (PDMS)-carbon composite membranes. These membranes enable the generation of uniform elec. fields inside the droplets, while simultaneously preventing the formation of electrolytic byproducts. Biomols. of different sizes migrate toward one side of the droplets, according to their net charge, when exposed to the elec. field. Directly afterward, a Y-junction promotes droplet splitting, resulting in the generation of biomol.-enriched daughter droplets. Biomols. were fluorescently labeled, and fluorescence microscopy was employed to assess their electrophoretic separation and enrichment. Exptl. results demonstrate how the enrichment of biomols. is influenced by their size, charge, and concentration, by the ionic strength, viscosity, and pH of the suspending medium, and by the in-droplet flow profile. Enrichments above 95% were observed for small mols. and highly charged species at velocities over 10 mm/s (13 droplets per s). Moreover, the enrichment performance asymptotically approached a value of 38% for velocities as high as 50 mm/s, demonstrating the potential of this technique for the high-throughput separation of charged species. The applicability of the system was demonstrated by cleaving a peptide and selectively separating the cleaved fragments in different daughter droplets on the basis of their net charge. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Characterisation of nociception and inflammation observed in traumatic muscle injury model in rats was written by Kudsi, Sabrina Qader;Antoniazzi, Caren Tatiane de David;Camponogara, Camila;Brum, Evelyne da Silva;Brusco, Indiara;Peres, Diulle Spat;Fischer, Susana Paula Moreira;Dalenogare, Diessica Padilha;Stein, Carolina dos Santos;Zaccaron, Rubya Pereira;Silveira, Paulo Cesar Lock;Moresco, Rafael Noal;Oliveira, Sara Marchesan;Trevisan, Gabriela. And the article was included in European Journal of Pharmacology in 2020.COA of Formula: C20H10Cl2O5 This article mentions the following:

Muscle pain is the most prevalent type of pain in the world, but treatment remains ineffective. Thus, it is relevant to develop trustable animal models to understand the involved pain mechanisms. Therefore, this study characterised the nociception and inflammation in a traumatic muscle injury model in rats. A single blunt trauma impact on the right gastrocnemius muscle of male Wistar rats (250-350 g) was used as model for muscle pain. Animals were divided into four groups (sham/no treatment; sham/diclofenac 1%; injury/no treatment; injury/diclofenac 1%) and the topical treatment with a cream containing 1% monosodium diclofenac (applied at 2, 6, 12, 24, and 46 h after muscle injury; 200 mg/muscle) was used as an anti-inflammatory control. Nociception (mech. and cold allodynia, or nociceptive score) and locomotor activity were evaluated at 26 and 48 h after injury. Also, inflammatory and oxidative parameters were evaluated in gastrocnemius muscle and the creatine kinase (CK) activity and lactate/glicose levels in rat’s serum and plasma, resp. Muscle injury caused mech. and cold allodynia, and increased nociceptive scores, without inducing locomotor impairment. This model also increased the inflammatory cells infiltration (seen by myeloperoxidase and N-acetyl-β-D-glucosaminidase activities and histol. procedure), nitric oxide, interleukin (IL)-1β, IL-6, and dichlorofluorescein fluorescence in muscle samples; and CK activity and lactate/glicose ratio. The treatment with 1% monosodium diclofenac reduced inflammatory cells infiltration, dichlorofluorescein fluorescence and lactate/glicose levels. Thus, we characterised the traumatic muscle injury as a reproducible model of muscle pain, which makes it possible to evaluate promising antinociceptive and anti-inflammatory therapies. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0COA of Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.COA of Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biogenic silver nanoparticles reduce Toxoplasma gondii infection and proliferation in RAW 264.7 macrophages by inducing tumor necrosis factor-alpha and reactive oxygen species production in the cells was written by Arruda da Silva Sanfelice, Raquel;Silva, Taylon Felipe;Tomiotto-Pellissier, Fernanda;Bortoleti, Bruna Taciane da Silva;Lazarin-Bidoia, Danielle;Scandorieiro, Sara;Nakazato, Gerson;de Barros, Luiz Daniel;Garcia, Joao Luis;Verri, Waldiceu Aparecido;Conchon-Costa, Ivete;Pavanelli, Wander Rogerio;Costa, Idessania Nazareth. And the article was included in Microbes and Infection in 2022.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Owing to the serious adverse effects caused by pyrimethamine and sulfadiazine, the drugs commonly used to treat toxoplasmosis, there is a need for treatment alternatives for this disease. Nanotechnol. has enabled significant advances toward this goal. This study was conducted to evaluate the activity of biogenic silver nanoparticles (AgNp-Bio) in RAW 264.7 murine macrophages infected with the RH strain of Toxoplasma gondii. The macrophages were infected with T. gondii tachyzoites and then treated with various concentrations of AgNp-Bio. The cells were evaluated by microscopy, and culture supernatants were collected for ELISA determination of their cytokine concentration Treatment with 6μM AgNp-Bio reduced the infection and parasite load in infected RAW 264.7 macrophages without being toxic to the cells. The treatment also induced the synthesis of reactive oxygen species and tumor necrosis factor-alpha (both pro-inflammatory mediators), which resulted in ultrastructural changes in the tachyzoites and their intramacrophagic destruction. Our findings suggest that AgNp-Bio affect T. gondii tachyzoites by activating microbicidal and pro-inflammatory mechanisms and may be a potential alternative treatment for toxoplasmosis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Investigation of Fluorescent Substrates and Substrate-Dependent Interactions of a Drug Transporter Organic Anion Transporting Polypeptide 2B1 (OATP2B1) was written by Kawasaki, Tatsuya;Shiozaki, Yuichi;Nomura, Naoki;Kawai, Kumi;Uwai, Yuichi;Nabekura, Tomohiro. And the article was included in Pharmaceutical Research in 2020.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Abstract: Purpose: In this study, we investigated organic anion transporting polypeptide 2B1 (OATP2B1)-mediated uptake of fluorescent anions to better identify fluorescent substrates for in vitro OATP2B1 assays. The OATP2B1 is involved in the intestinal absorption and one of the pharmacokinetic determinants of orally administered drugs. Methods: A microplate reader was used to determine the cellular accumulation of the fluorescent compounds into the OATP2B1 or the empty vector-transfected HEK293 cells. Results: Two types of derivatives were found to be OATP2B1 substrates: heavy halogenated derivatives, such as 4′,5′-dibromofluorescein (DBF), and carboxylated derivatives, such as 5-carboxyfluorescein (5-CF). The DBF and 5-CF were transported in a time and concentration-dependent manner. The DBF was transported at a broad pH (pH 6.5-8.0) while 5-CF was transported at an acidic pH (pH 5.5-6.5). The K_m values were 0.818 ± 0.067μM at pH 7.4 for DBF and 8.56 ± 0.41μM at pH 5.5 for 5-CF. The OATP2B1 inhibitors, including atorvastatin, bromosulfophthalein, glibenclamide, sulfasalazine, talinolol, and estrone 3-sulfate, inhibited the DBF and the 5-CF transport. Contrastively, testosterone, dehydroepiandrosterone sulfate, and progesterone inhibited the DBF transport but stimulated the 5-CF transport. Natural flavonoid aglycons, such as naringenin and baicalein, also exhibited substrate-dependent effects in this manner. Conclusion: We found two fluorescein analogs, DBF and 5-CF as the OATP2B1 substrates that exhibited substrate-dependent interactions. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Abeta42) and Protect from Abeta42 Induced Oxidative Damage in Yeast Models of Alzheimer’s Disease was written by Dhakal, Sudip;Ramsland, Paul A.;Adhikari, Benu;Macreadie, Ian. And the article was included in International Journal of Molecular Sciences in 2021.HPLC of Formula: 76-54-0 This article mentions the following:

Finding an effective therapeutic to prevent or cure AD has been difficult due to the complexity of the brain and limited exptl. models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organisms to find potential natural bioactive compounds capable of reducing intracellular amyloid beta 42 (Aβ42) and associated oxidative damage. Eleven natural bioactive compounds including mangiferin, quercetin, rutin, resveratrol, epigallocatechin gallate (EGCG), urolithin A, oleuropein, rosmarinic acid, salvianolic acid B, baicalein and trans-chalcone were screened for their ability to reduce intracellular green fluorescent protein tagged Aβ42 (GFP-Aβ42) levels. The two most effective compounds from the screens were combined in varying concentrations of each to study the combined capacity to reduce GFP-Aβ42. The most effective combinations were examined for their effect on growth rate, turnover of native Aβ42 and reactive oxygen species (ROS). The bioactive compounds except mangiferin and urolithin A significantly reduced intracellular GFP-Aβ42 levels. Baicalein and trans-chalcone were the most effective compounds among those that were screened. The combination of baicalein and trans-chalcone synergistically reduced GFP-Aβ42 levels. A combination of 15μM trans-chalcone and 8μM baicalein was found to be the most synergistic combination. The combination of the two compounds significantly reduced ROS and Aβ42 levels in yeast cells expressing native Aβ42 without affecting growth of the cells. These findings suggest that the combination of baicalein and trans-chalcone could be a promising multifactorial therapeutic strategy to cure or prevent AD. However, further studies are recommended to look for similar cytoprotective activity in humans and to find an optimal dosage. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synergistic photodynamic and photothermal effects of organic nanomaterials derived from cross-linked porphyrin polymer was written by Zhang, Ruilin;Zhu, Yuyan;Luo, Xiaogang;Zhang, Quanquan;Wu, Fengshou. And the article was included in Journal of Porphyrins and Phthalocyanines in 2022.Application of 76-54-0 This article mentions the following:

Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising therapeutic methods for cancer treatment. However, both PDT and PTT have their own limitations. Thus, it is highly desirable to synthesize a single photosensitizer, which exhibits both PDT and PTT therapeutic performances. We have designed and synthesized a new porphyrin-based polymer (ZP-PT) by crosslinking fluoroporphyrins (ZnPor) and HS-terminated pentaerythritol tetra(3-mercaptopropionate) (PETMP). After being transformed into nanoparticles (ZP-PT NPs), they showed excellent water dispersity with the average size of about 100 nm. ZP-PT NPs could generate reactive oxygen species (ROS) and thermal energy under 635 nm laser irradiation The singlet oxygen yield and the photothermal conversion efficiency (PCE) of ZP-PT NPs were calculated to be 0.46 and 27.07% resp., which were apparently higher than that of ZnPor NPs. In addition, ZP-PT NPs exhibited higher colloidal stability and photostability than that of ZnPor NPs. All these results suggested that ZP-PT NPs had great potential in photodynamic and photothermal synergistic treatment of cancer. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Disparities in particulate matter (PM₁₀) origins and oxidative potential at a city scale (Grenoble, France) – part 2: sources of PM10 oxidative potential using multiple linear regression analysis and the predictive applicability of multilayer perceptron neural network analysis was written by Borlaza, Lucille Joanna S.;Weber, Samuel;Jaffrezo, Jean-Luc;Houdier, Stephan;Slama, Remy;Rieux, Camille;Albinet, Alexandre;Micallef, Steve;Trebluchon, Cecile;Uzu, Gaelle. And the article was included in Atmospheric Chemistry and Physics in 2021.HPLC of Formula: 76-54-0 This article mentions the following:

The oxidative potential (OP) of particulate matter (PM) measures PM capability to potentially cause anti-oxidant imbalance. Due to the wide range and complex mixture of species in particulates, little is known about the pollution sources most strongly contributing to OP. A 1-yr sampling of PM₁₀ (particles with an aerodynamic diameter below 10) was performed over different sites in a medium-sized city (Grenoble, France). An enhanced fine-scale apportionment of PM₁₀ sources, based on the chem. composition, was performed using the pos. matrix factorization (PMF) method and reported in a companion paper. OP was assessed as the ability of PM10 to generate reactive oxygen species (ROS) using three different acellular assays: dithiothreitol (DTT), ascorbic acid (AA), and 2,7-dichlorofluorescein (DCFH) assays. Using multiple linear regression (MLR), the OP contributions of the sources identified by PMF were estimated Conversely, since atm. processes are usually non-linear in nature, artificial neural network (ANN) techniques, which employ non-linear models, could further improve estimates Hence, the multilayer perceptron anal. (MLP), an ANN-based model, was addnl. used to model OP based on PMF-resolved sources as well. This study presents the spatiotemporal variabilities of OP activity with influences by season-specific sources, site typol. and specific local features, and assay sensitivity. Overall, both MLR and MLP effectively captured the evolution of OP. The primary traffic and biomass burning sources were the strongest drivers of OP in the Grenoble basin. There is also a clear redistribution of source-specific impacts when using OP instead of mass concentration, underlining the importance of PM redox activity for the identification of potential sources of PM toxicity. Finally, the MLP generally offered improvements in OP prediction, especially for sites where synergistic and/or antagonistic effects between sources are prominent, supporting the value of using ANN-based models to account for the non-linear dynamics behind the atm. processes affecting OP of PM₁₀. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem