Tag: 400-500

Cause-and-Effect Analysis as a Tool To Improve the Reproducibility of Nanobioassays: Four Case Studies was written by Petersen, Elijah J.;Hirsch, Cordula;Elliott, John T.;Krug, Harald F.;Aengenheister, Leonie;Arif, Ali Talib;Bogni, Alessia;Kinsner-Ovaskainen, Agnieszka;May, Sarah;Walser, Tobias;Wick, Peter;Roesslein, Matthias. And the article was included in Chemical Research in Toxicology in 2020.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

One of the challenges in using in vitro data to understand the potential risks of engineered nanomaterials (ENMs) is that results often differ or are even contradictory among studies. While it is recognized that numerous factors can influence results produced by nanobioassays, there has not yet been a consistently used conceptual framework to identify key sources of variability in these assays. In this paper, we use cause-and-effect anal. to systematically describe sources of variability in four key in vitro nanobioassays: the DCF (2′,7′-dichlorofluorescein) assay, an ELISA for measuring interleukin-8, a flow cytometry assay (Annexin V/Propidium Iodide), and the Comet assay. These assays measure endpoints that can occur in cells impacted by ENMs through oxidative stress, a principle mechanism for ENM toxicity. The results from this anal. identify control measurements to test for potential artifacts or biases that could occur during conduct of these assays with ENMs. Cause-and-effect anal. also reveal addnl. measurements that could be performed either in preliminary experiments or each time the assay is run to increase confidence in the assay results and their reproducibility within and among laboratories The approach used here with these four assays can be used the support the development of a broad range of nanobioassays. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis was written by Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A.. And the article was included in Catalysis Communications in 2019.Formula: C20H10Cl2O5 This article mentions the following:

Zn_1-xTi_xO NPs were efficiently synthesized using a simple solution free mechanochem. method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn_1-xTi_xO catalysts were pos. correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodol. was also extended to sulfone-fluorescein dye synthesis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile Homobifunctional Imidoester Modification of Advanced Nanomaterials for Enhanced Antibiotic Synergistic Effect was written by Liu, Huifang;Zou, Qingshuang;Qiao, Zhen;Jang, Yoon Ok;Koo, Bonhan;Kim, Myoung Gyu;Lee, Hyo Joo;Kim, Sung-Han;Shin, Yong. And the article was included in ACS Applied Materials & Interfaces.Computed Properties of C20H10Cl2O5 This article mentions the following:

Resistance to antibiotics because of misuse and overuse is one of the greatest public health challenges worldwide. Despite the introduction of advanced nanotechnol. in the production of antibiotics, the choice of appropriate medicines is limited due to side effects such as blood coagulation, toxicity, low efficacy, and low biocompatibility; therefore, novel nanomaterial composites are required to counter these repercussions. We first introduce a facile method for synthesizing a homobifunctional imidoester-coated nanospindle (HINS) zinc oxide composite for enhancement of antibiotic efficacy and reduction of toxicity and blood coagulation. The antibiotic efficacy of the composites is twice that of commercialized zinc nanoparticles; in addition, they have good biocompatibility, have increased surface charge and solubility owing to the covalent acylation groups of HI, and produce a large number of Zn+ ions and defensive reactive oxygen species (ROS) that effectively kill bacteria and fungi. The synergistic effect of a combination therapy with the HINS composite and itraconazole shows more than 90% destruction of fungi in treatments with low dosage with no cytotoxicity or coagulation evident in i.v. administration in in vitro and in vivo experiments Thus, HINS composites are useful in reducing the effect of misuse and overuse of antibiotics in the medical field. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mentha rhizomes as an alternative source of natural antioxidants was written by Fialova, Silvia Bittner;Kurin, Elena;Trajcikova, Eva;Janosova, Lucia;Susanikova, Ivana;Tekel’ova, Daniela;Nagy, Milan;Mucaji, Pavel. And the article was included in Molecules in 2020.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Unlike its aerial parts, the underground parts of Mentha have so far been studied only marginally. By examining the polyphenolic fingerprint, the antioxidant efficacy and the mutual antioxidant behavior of mixtures of mint rhizomes, our study presents a modest contribution to addressing this gap. Firstly, we examined the composition of the mint rhizomes: Mentha × piperita cv. ‘Perpeta’ (MPP), M. longifolia (ML), and M. × villosa cv. ‘Snezna’ (MVS). Our LC-MS-DAD anal. revealed the presence of ten compounds belonging to groups of phenolic acids and flavonoids, of which the rosmarinic acid (RA) and lithospermic were most strongly represented. Secondly, we evaluated the antioxidant activity of rhizome infusions by DPPH and ABTS and on NIH/3T3 cell lines by DCFH-DA. Thirdly, we determined, examined, and explained the mutual interactions of rhizome infusions mixtures While most of the combinations acted additive, synergy was observed in ternary infusion mixtures The combinations of mint rhizomes and rosmarinic acid displayed a high dose-reduction index. This leads to beneficial dose reduction at a given antioxidant effect level in mixtures, compared to the dose of the parts used alone. So far, the pharmaceutical and food industry has not used mint rhizomes in com. products. Hence, our study draws attention to further applications of the Mentha rhizomes as a valuable alternative source of natural antioxidants. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effects of cryotherapy on the regeneration process and muscular mechanical properties after lacerative injury model. was written by Dos Santos Haupenthal, Daniela Pacheco;de Bem Silveira, Gustavo;Zaccaron, Rubya Pereira;Corrêa, Maria Eduarda Anastácio Borges;de Souza, Priscila Soares;Filho, Mário Cesar Búrigo;de Roch Casagrande, Laura;de Melo Cardoso, Mariana;Rigo, Flávia Karine;Haupenthal, Alessandro;Silveira, Paulo Cesar Lock. And the article was included in Scandinavian journal of medicine & science in sports in 2021.Reference of 76-54-0 This article mentions the following:

Cryotherapy is a therapeutic modality widely used for the treatment of muscle injuries to control pain and inflammatory processes. This study aimed to investigate the effects of cryotherapy on the inflammatory and oxidative stress parameters and mechanical properties of, and pain in, the skeletal muscles of rats with lacerative muscle injury. The rats were anesthetized with 4% isoflurane and subjected to gastrocnemius muscle laceration injury. After injury, all animals in the intervention groups received cryotherapy treatment for 20 minutes using plastic bags containing crushed ice. The protocol comprised three daily applications at 3-hour intervals on the day of injury, with reapplication 24 hours later. Seventy-two male Wistar rats were divided into three groups: sham, muscle injury (MI), and MI + cryotherapy (MI + cryo). Muscle mechanical properties were analyzed by mechanical tensile testing on day 7 after injury. The MI + cryo group showed reduced TNF-α, IFN-γ, and IL1β levels; elevated IL4, IL6, and IL10 levels; reduced oxidant production and carbonyl levels; and elevated sulfhydryl contents. Animals that underwent tissue cooling showed superoxide dismutase activity and glutathione levels close to those of the animals in the sham group. The MI and MI + cryo groups showed reduced values of the evaluated mechanical properties and lower mechanical thresholds compared to those of the animals from the sham group. Our results demonstrated that the proposed cryotherapy protocol reduced the inflammatory process and controlled oxidative stress but did not reverse the changes in the mechanical properties of muscle tissues or provide analgesic effects within the time frame analyzed. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Spectrofluorimetry – cloud point extraction determination of trace arsenic (III) with 2′,7′-dichlorofluorescein was written by Abbas, Ahmed S.. And the article was included in Journal of Physics: Conference Series in 2019.Product Details of 76-54-0 This article mentions the following:

In this work, explains a separation and Preconcentration procedure for the determination of arsenic (III) by spectrofluorimetric method after complexation with the 2′,7′-dichlorofluorescein as a fluorogenic reagent agent presence by the nonionic surfactant Triton X-114 in λex 271 nm and λ em 537 nm, after that, the quant. isolated into a unimportant volume of the surfactant-rich phase later a centrifugation. The optimum conditions, such as pH, volume of surfactant and reagent (TritonX-114), equilibrium temperature and incubation time on the cloud point extraction procedure, were studied and optimized on the extraction productivity percentage. In this method limits of detection and quantification LOD and LOQ of As(III) ion was (0.102) and (0.525) ng/mL resp., and a linear calibration range of (5.0 -50.0) ng/mL for As(III). The proposed method has been successfully applied to the determination of As(III) ion in water samples with agreeable results. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Product Details of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production was written by Xiao, Tingying;Sun, Jian;Xing, Zhankui;Xie, Fuqiang;Yang, Lan;Ding, Wenjuan. And the article was included in Cell Biology International in 2020.Product Details of 76-54-0 This article mentions the following:

Mitochondrial fission process 1 (MTFP1) is a novel nuclear-encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biol. effects of MTFP1 in cancer development is still unclear, especially in oral squamous cell carcinoma (OSCC). In this study, we first evaluated the expression of MTFP1 in 12-paired OSCC tumor and peritumor tissues. We then explored the effects of MTFP1 knockdown or overexpression on cell growth by cell proliferation, colony formation, cell cycle, and cell apoptosis assays. Furthermore, the mechanisms by which MTFP1 promoted OSCC cell growth were explored. Our results showed that MTFP1 is frequently overexpressed in OSCC tissues. Functional experiments revealed that MTFP1 promoted the growth of OSCC cells by inducing the progression of cell cycle and suppressing cell apoptosis. Mechanistically, MTFP1 overexpression-mediated mitochondrial fragmentation and subsequent ROS production was found to be involved in the promotion of OSCC cell growth. Collectively, our study demonstrates that MTFP1 plays a critical oncogenic role in OSCC carcinogenesis, which may serve as a potential therapeutic target in the treatment of this malignance. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Product Details of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity was written by Ma, Xiang;Hua, Jiai;Wang, Man;Zhang, Deqiang;Pei, Xinyao;Zhao, Xiaoyu;Niu, Yulan;Wang, Yanqing. And the article was included in Catalysts in 2022.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention as a catalyst for ROS generation in fields ranging from bioinorganic chem. to pharmaceutical chem. In this study, an artificial oxidase based on a binuclear zinc complex and Keggin-type silicotungstate [Zn₂(4,4′-bpy)(Phen)₂][SiW₁₂O₄₀] (ZSW) (4,4′-bpy = 4,4′-bipyridine; Phen = 1,10-phenanthroline) was synthesized and structurally featured in terms of its X-ray photoelectron spectrum (XPS), bond valence sum (Σs) calculation, IR spectra, and single-crystal X-ray diffraction (SXRD). ZSW is an ionic compound in which the cation is a binuclear zinc complex [Zn₂(4,4′-bpy)(Phen)2]4⁺ and the anion is a α-Keggin-type silicotungstate [SiW₁₂O₄₀]^4- cluster. Notably, the Zn ions in the [Zn2(4,4′-bpy)(Phen)₂] exist in tri-coordination, which was first obtained in polyoxometalate (POM) chem. It was also demonstrated that ZSW is capable of efficiently catalyzing the production of ROS, which, according to the computational calculations, may be due to the synergistic action of zinc complexes and POM building blocks. Furthermore, ZSW exhibited inhibition ability toward ROS-sensitive tumor cells, such as PC12 cells. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Silica nanoparticles with thermally activated delayed fluorescence for live cell imaging was written by Crucho, Carina I. C.;Avo, Joao;Nobuyasu, Roberto;N. Pinto, Sandra;Fernandes, Fabio;Lima, Joao C.;Berberan-Santos, Mario N.;Dias, Fernando B.. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Category: benzofurans This article mentions the following:

Thermally activated delayed fluorescence (TADF) has revolutionized the field of organic light emitting diodes owing to the possibility of harvesting non-emissive triplet states and converting them in emissive singlet states. Despite this strong potential, only recently TADF has emerged as a powerful tool to develop metal-free long-lived luminescent probes for imaging and sensing. The application of TADF mols. in aqueous and/or biol. media requires specific structural features that allow complexation with biomols. or enable emission in the aggregated state, in order to retain the delayed fluorescence that is characteristic of these compounds Herein we demonstrate a facile method that maintains the optical properties of solvated dyes by dispersing TADF mols. in nanoparticles. TADF dye-doped silica nanoparticles are prepared using a modified fluorescein fluorophore. However, the strategy can be used with many other TADF dyes. The covalent grafting of the TADF emitter into the inorganic matrix effectively preserves and transfers the optical properties of the free dye into the luminescent nanomaterials. Importantly, the silica matrix is efficient in shielding the dye from solvent polarity effects and increases delayed fluorescence lifetime. The prepared nanoparticles are effectively internalized by human cells, even at low incubation concentrations, localizing primarily in the cytosol, enabling fluorescence microscopy imaging at low dye concentrations In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Category: benzofurans).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function. was written by Kiander, Wilma;Sjostedt, Noora;Manninen, Riikka;Jaakkonen, Liina;Vellonen, Kati-Sisko;Neuvonen, Mikko;Niemi, Mikko;Auriola, Seppo;Kidron, Heidi. And the article was included in European Journal of Pharmaceutical Sciences in 2022.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Organic Anion Transporting Polypeptide 1B1 is important to the hepatic elimination and distribution of many drugs. If OATP1B1 function is decreased, it can increase plasma exposure of e.g. several statins leading to increased risk of muscle toxicity. First, we examined the impact of three naturally occurring rare variants and the frequent SLCO1B1 c.388A>G variant on in vitro transport activity with cellular uptake assay using two substrates: 2′, 7′-dichlorofluorescein (DCF) and rosuvastatin. Secondly, LC-MS/MS based quant. targeted absolute proteomics measured the OATP1B1 protein abundance in crude membrane fractions of HEK293 cells over-expressing these single nucleotide variants. Addnl., we simulated the effect of impaired OATP1B1 function on rosuvastatin pharmacokinetics to estimate the need for genotype-guided dosing. R57Q impaired DCF and rosuvastatin transport significantly yet did not change protein expression considerably, while N130D and N151S did not alter activity but increased protein expression. R253Q did not change protein expression but reduced DCF uptake and increased rosuvastatin K_m. Based on pharmacokinetic simulations, doses of 30 mg (with 50% OATP1B1 function) and 20 mg (with 0% OATP1B1 function) result in plasma exposure similar to 40 mg dose (with 100% OATP1B1 function). Therefore dose reductions might be considered to avoid increased plasma exposure caused by function-impairing OATP1B1 genetic variants, such as R57Q. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem