Tag: 347.3209

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes was written by Ruivo, Eduardo F. P.;Goncalves, Lidia M.;Carvalho, Luis A. R.;Guedes, Rita C.;Hofbauer, Stefan;Brito, Jose A.;Archer, Margarida;Moreira, Rui;Lucas, Susana D.. And the article was included in ChemMedChem in 2016.Application of 3326-34-9 This article mentions the following:

Human neutrophil elastase (HNE) is a serine protease associated with several inflammatory processes such as chronic obstructive pulmonary disease (COPD). The precise involvement of HNE in COPD and other inflammatory disease mechanisms has yet to be clarified. Herein the authors report a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC, or ‘click’ chem.) approach based on the 4-oxo-β-lactam warhead that yielded potent HNE inhibitors containing a triazole moiety. The resulting structure-activity relationships set the basis to develop fluorescent and biotinylated activity-based probes as tools for mol. functional anal. Attaching the tags to the 4-oxo-β-lactam scaffold did not affect HNE inhibitory activity, as revealed by the IC₅₀ values in the nanomolar range (56-118 nM) displayed by the probes. The nitrobenzoxadiazole (NBD)-based probe presented the best binding properties (ligand efficiency (LE)=0.31) combined with an excellent lipophilic ligand efficiency (LLE=4.7). Moreover, the probes showed adequate fluorescence properties, internalization in human neutrophils, and suitable detection of HNE in the presence of a large excess of cell lysate proteins. This allows the development of activity-based probes with promising applications in target validation and identification, as well as diagnostic tools. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Application of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Unexpected Reactivity of N-Acyl-Benzotriazoles with Aromatic Amines in Acidic Medium (ABAA Reaction) was written by Laconde, Guillaume;Amblard, Muriel;Martinez, Jean. And the article was included in European Journal of Organic Chemistry in 2019.Computed Properties of C20H13NO5 This article mentions the following:

Despite the large number of methods for the synthesis of amides, formation of the amide bond from aromatic amines has always been a challenge for organic chemists due to their weak nucleophile character. The authors describe here a new efficient method of amide formation from N-Acyl-Benzotriazoles and Aromatic Amines (ABAA reaction) including aniline derivatives, in acidic conditions. This reaction is selective for aromatic amines, since aliphatic amines did not react under the same exptl. conditions. Using the ABAA reaction, the authors synthesized a series of aromatic amide compounds including labeled enzyme substrates, in excellent yield. The ABAA reaction also allowed the one-pot synthesis of Nordiazepam, which is a precursor of the anxiolytic Diazepam (Valium). This procedure opens new ways of synthesis of amides from aromatic amines, and of heterocyclic structures. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Computed Properties of C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct peptide cyclization and one-pot modification using the MeDbz linker was written by Gless, Bengt H.;Olsen, Christian A.. And the article was included in Journal of Organic Chemistry in 2018.COA of Formula: C20H13NO5 This article mentions the following:

The one-pot synthesis and modification of cyclic peptides through a self-cleaving on-resin protocol is described. We apply Dawson’s MeDbz linker to achieve direct intramol. peptide cyclization by thioesterification followed by S → N acyl shift. This native chem. ligation approach requires no activating additive and allows direct modification of the crude cyclic peptides in one-pot. The strategy was applied to synthesize 5 cyclic peptide natural products of varying ring size. Finally, one-pot modifications include desulfurization, fluorophore conjugation, and intramol. disulfide formation. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9COA of Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

High-throughput extracellular pH monitoring and antibiotics screening by polymeric fluorescent sensor with LCST property was written by Pan, Tingting;Yang, Cheng;Li, Jiaze;Jiang, Jiapei;Wen, Jiaxing;Wang, Zijin;Zhong, Ke;Tian, Yanqing;Chen, Meiwan. And the article was included in Methods (Amsterdam, Netherlands) in 2019.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Herein, we synthesized two polymers for pHe monitoring which are soluble in water at room temperature with easy operations and high reproducibility among various micro-plate wells for high-throughput anal. P1 (P(OEGMA-co-MEO₂MA-co-pHS)) and P2 (P(OEGMA-co-pHS)) were synthesized via the Reversible Addition Fragmentation Chain Transfer (RAFT) copolymerization of OEGMA, MEO₂MA and the pH sensitive fluorescence moiety N-fluoresceinyl methacrylamide (pHS). P1 is soluble in water at room temperature (25°C) while insoluble at the temperature above 33°C, indicating its feature of lower critical solution temperature (LCST) at 33°C. Further P1 showed higher pH sensitivity and photostability than P2 (without LCST property) when used at physiol. temperature (37°C). Thus, P1 was chosen to in-situ monitor the micro-environmental acidification of E. coli, Hela and Ramos cells during their growth, and the metabolism inhibiting activity of a representative antibiotic, ampicillin. Cell concentration-dependent cellular acidification and drug concentration-dependent inhibition of cellular acidification were observed, demonstrating that the LCST polymer (P1) is suitable for real-time cellular acidification monitoring as well as for high-throughput drug screening. This study firstly demonstrated the use of a LCST polymeric sensor for high-throughput screening of antibiotics and investigation of cell metabolism In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chain diffusion and exchange during build-up of hydrogen-bonded polymer complex film was written by Rehan, Kiran;Su, Chao;Nie, Jing;Xu, Jian;Yang, Shuguang. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2018.Formula: C20H13NO5 This article mentions the following:

Poly(vinylpyrrolidone) (PVPON) and poly(acrylic acid) (PAA) were layer-by-layer (LbL) assembled to prepare thin film based on hydrogen bonding. A series of simple experiments were designed to investigate polymer chain diffusion and exchange behaviors of hydrogen-bonded PVPON/PAA film. PAA was labeled with fluorescence dye, fluorescein amine (FAM). The prepared (PVPON/PAA)₂₀ films were immersed into PAA solution, PVPON solution and PAA-FAM solution sep., for a period that was much longer than the assembly time, and the thickness, the composition and the characteristic absorbance of the film were monitored. The experiment results indicated that polymers not only diffused into the thin film from the assembly solution but also diffused out from the thin film into the assembly solution, i.e. there existed a polymer chain exchange. The growth of hydrogen-bonded PVPON/PAA film was related with polymer chain diffusion and exchange at a certain time scale. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Thermoresponsive Dynamic Covalent Polymers with Tunable Properties was written by Li, Jingyi;Yang, Shixia;Wang, Lin;Wang, Xiaobei;Liu, Li. And the article was included in Macromolecules (Washington, DC, United States) in 2013.HPLC of Formula: 3326-34-9 This article mentions the following:

A bisaldehyde-containing trithiocarbonate chain transfer agent was prepared and mediated the synthesis of polymers with bisaldehyde-functionalized α-termini by reversible addition-fragmentation chain transfer (RAFT) radical polymerization The α-termini of RAFT-derived thermoresponsive poly-(N-isopropylacrylamide) was conjugated with hydrazides via reversible acylhydrazone bonds. Introduction of hydrophilic end-groups generated a dynamic covalent polymer with “isothermal” lower critical solution temperature (LCST) response to medium pH and dynamic chain exchange character. A biofunctional dynamic covalent polymer was prepared by conjugation with biotin hydrazide. Under appropriate reaction conditions, a dynamic covalent block copolymer with an aldehyde group at the junction point was constructed through a reversible arylhydrazone linkage by coupling with acylhydrazide-terminated poly-(ethylene glycol). The dynamic covalent block copolymer exhibited pH-dependent LCST. The remaining aldehyde group was used to react with amino-containing mols. Bioconjugated dynamic covalent block copolymers containing reversible imine and arylhydrazone linkages were constructed by conjugation of the block copolymer to glucosamine and protein. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9HPLC of Formula: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effect of hydrophilic polymer modification of reverse osmosis membrane surfaces on organic adsorption and biofouling behavior was written by Saeki, Daisuke;Yonamine, Genki;Matsuyama, Hideto. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021.Reference of 3326-34-9 This article mentions the following:

Biofouling in reverse osmosis (RO) membranes is a serious problem, owing to the inherent membrane performance and lifetime; therefore, there have been attempts on various surface modifications of RO membrane surfaces using hydrophilic polymers. This study evaluates the effect of hydrophilic polymers modified on RO membrane surfaces on the adsorption of organic foulants causing biofouling and resulting in biofouling behavior. Polyamide RO membrane surfaces modified by three types of hydrophilic polymers, namely, 2-[(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSAH), 2-hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) Me ether methacrylate (PEGMA), were fabricated via an interfacial polymerization method and surface-initiated atom transfer radical polymerization (SI-ATRP). The hydrophilic property of each polymer is attributed to different functional groups: a zwitterionic group, hydroxyl group, and PEG group, resp. To evaluate the anti-biofouling properties, the adsorption properties against bacteria, proteins and polysaccharides were quantified using a fluorescent-labeling method, and the biofouling behavior was evaluated during the filtration test. Fluorescently labeled alginate was synthesized for the adsorption test. Each hydrophilic polymer showed different adsorption properties against each organic foulant; none of the hydrophilic polymers was effective in the prevention of polysaccharide adsorption. The biofouling test showed that the zwitterionic polymer, MEDSAH, had superior anti-biofouling properties compared to the other hydrophilic polymers because of its high anti-adsorption property against bacteria. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Reference of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Multifunctional Flexible Polyimides for Electroactive Devices with Electrochromic, Electrofluorochromic, and Photodetection Properties was written by Zheng, Rong-rong;Huang, Tao;Niu, Hai-jun;Wang, Cheng;Chang, Hai-yang;Sun, Zhi-yao;Wang, Li-yan;Guo, Li-ying;Zhang, Zhi-peng;Zhang, Shuo. And the article was included in ACS Applied Polymer Materials in 2021.Formula: C20H13NO5 This article mentions the following:

In this study, we report three electroactive carbazolyl polyimides (PIs) containing spiropyran, pyrene, and fluorescein fluorescent groups. The PIs exhibit red, blue, and green fluorescence emissions, resp. The PIs exhibit aggregation-induced emission and electrochromic (EC) and electrofluorochromic properties. Moreover, white light emission can be achieved by adjusting the mixing ratio of the three PIs. The PIs show high photoluminescence intensity in a solution and solid state. Interestingly, as the volume of Et acetate in the PI DMSO solutions increases, the fluorescence intensity increases continuously. This is due to the decrease in solvent polarity and is distorted by the twisted intramol. charge-transfer effect, enhancing the emission intensity. The PI films have excellent electrochem. stability between the neutral and first oxidation states of 2000 cycles, and their elec. activities are maintained at 99% CzpP-SPP, 99% CzpP-PREP, and 99% CzpP-FRNP. Under the action of an external elec. field, the PIs exhibit excellent EC performance, and the highest EC efficiency was 187 cm² C^-1. Furthermore, the fluorescence and color switching between the oxidation state (nonfluorescent state) and reduced state (fluorescent state) of the PI films are reversible. This work provides a simple strategy for the direct functionalization of Cz-based materials and opens the way for exploring more applications of Cz-based materials. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effect of histological feature of leather on acrylic resin retanning was written by Song, Ying;Zeng, Yunhang;Shi, Bi. And the article was included in Journal of the Society of Leather Technologists and Chemists in 2018.Safety of 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

The effect of histol. features of leather on acrylic resin retanning was investigated by retanning pigskin, cattle hide and sheepskin leathers with fluorescein-labeled poly(acrylic acid) (PAA). A deeper penetration and a higher uptake rate of PAA were observed in the belly area of pigskin leather compared to in its butt area. This led to a greater increase in leather thickness of the belly. As for cattle hide and sheepskin leathers whose structural difference in various parts is not obvious, the differences in penetration and uptake of PAA and increase in leather thickness between their butts and their bellies were relatively slight. These results indicated that acrylic resins penetrate and fill the thinner and looser parts of the leather more easily. This fact gives acrylic resins a good selective filling property and is helpful to level out the structure of leather. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Safety of 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HEPES is not suitable for fluorescence detection of HClO: a novel probe for HClO in absolute PBS was written by Xing, Panfei;Gao, Kuo;Wang, Beng;Gao, Jian;Yan, Hui;Wen, Jia;Li, Weisi;Xu, Yongqian;Li, Hongjuan;Chen, Jianxin;Wang, Wei;Sun, Shiguo. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 3326-34-9 This article mentions the following:

HEPES is not suitable for fluorescence detection of HClO because it can be oxidized by HClO. A novel probe for HClO, which can selectively and sensitively detect HClO in absolute PBS, was developed on the basis of an oxidation reaction with an azo moiety. Furthermore, it works well in live mouse imaging. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Related Products of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem