Tag: 200-300

Microwave assisted synthesis and pharmacological evaluation of some potent naphthofuryl- and benzofurylthiazole, -oxazole, -thiadiazine and -oxadiazine derivatives was written by Kumar, D. B. Aruna;Prakash, G. K.;Nandeshwarappa, B. P.;Kiran, B. M.;Sherigara, B. S.;Mahadevan, K. M.. And the article was included in Indian Journal of Pharmaceutical Sciences in 2006.Synthetic Route of C10H7BrO2 This article mentions the following:

Bromination of substituted 2-acetylbenzofurans gave substituted 2-(2-bromoacetyl)benzofurans. 2-(2-Bromoacetyl)benzofurans reacted with thiourea, urea, thiosemicarbazide and semicarbazide in presence of sodium acetate under microwave irradiation to give heterocyclyl benzo- and naphthofuran derivs, e.g., I and II. The structures of synthesized compounds have been established by elemental anal., spectral data. All the synthesized compounds were screened for antimicrobial, anthelmintic, antiinflammatory and analgesic activities. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Synthetic Route of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

2-Mercapto-4,6-disubstituted nicotinonitriles: versatile precursors for novel mono- and bis[thienopyridines] was written by Salem, Mostafa E.;Darweesh, Ahmed F.;Elwahy, Ahmed H. M.. And the article was included in Journal of Sulfur Chemistry in 2018.Formula: C10H7BrO2 This article mentions the following:

A series of novel thieno[2,3-b]pyridines were prepared from the reaction of the appropriate bromoacetylbenzofurans or bromoacetylbenzothiazole with the corresponding pyridinethione derivatives in ethanolic sodium ethoxide at reflux. New bis(thieno[2,3-b]pyridine) derivatives were synthesized by the reaction of the appropriate bis-bromoacetyl derivatives with the corresponding pyridinethiones in the presence of sodium ethoxide. Attempts to synthesize the target bis(thieno[2,3-b]pyridine) derivatives by bis-alkylation of the corresponding (thieno[2,3-b]pyridin-2-yl)(hydroxyphenyl)methanone with the appropriate dihaloalkanes using a mild base were unsuccessful. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biologically Active Heterocyclic Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties: Synthesis, Characterization, Cytotoxic and Antibacterial Evaluation was written by Asadi, Parvin;Khodarahmi, Ghadamali;Jahanian-Najafabadi, Ali;Saghaie, Lotfollah;Hassanzadeh, Farshid. And the article was included in Chemistry & Biodiversity in 2017.SDS of cas: 38220-75-6 This article mentions the following:

Cytotoxic and antimicrobial agents structurally based on quinazolinone, benzofuran and imidazole pharmacophores, have been designed and synthesized. Spectral (IR, ¹H-NMR) and elemental anal. data established the structures of these novel 3-[1-(1-benzofuran-2-yl)-2-(4-oxoquinazolin-3(4H)-yl)ethyl]-1-methyl-1H-imidazol-3-ium chloride hybrid derivatives All the synthesized compounds were evaluated for in vitro cytotoxicity and antimicrobial activities. Cytotoxic evaluation using MTT assay revealed that compounds 12c, 12g and 12i exhibited significant cytotoxicity with IC₅₀ values 1, 1, and 0.57 μM on this cell line, resp. Biol. activity of the synthesized compounds as antibacterial agent were also evaluated against three Gram-neg. (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi), three Gram-pos. (Staphylococcus aureus, Bacillus subtilis and Listeria monocitogenes) and one yeast-like fungi (Candida albicans) strains. All compounds 12a – 12i showed slightly higher activity against Gram-pos. bacteria than the Gram-neg. one. Among the nine new compounds screened, 3-[1-(5-bromo-1-benzofuran-2-yl)-2-(6-chloro-4-oxoquinazolin-3(4H)-yl)ethyl]-1-methyl-1H-imidazol-3-ium chloride (12e) has pronounced higher antimicrobial activity against all tested strains. These results demonstrated potential importance of mol. hybridization in the development of new lead mols. with major cytotoxicity and antimicrobial activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6SDS of cas: 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy was written by Li, Ying;Miao, Yunqiu;Chen, Mingshu;Chen, Xi;Li, Feifei;Zhang, Xinxin;Gan, Yong. And the article was included in Theranostics in 2020.HPLC of Formula: 38183-12-9 This article mentions the following:

Antitumor drug delivery faces multiple barriers that require consecutively achieving tumor targeting, selective cellular uptake and sufficient intracellular drug dosage. Herein, we designed smart nanoparticles (GPDC-MSNs) that can accumulate stepwise in tumor tissues, selectively enter cancer cells by responding to the acidic tumor extracellular environment, and achieve considerable drug release in the intracellular microenvironment. The GPDC-MSNs comprise the synthesized material galactosyl-conjugated PEO-PPO-PEO (Gal-P123) for hepatocellular carcinoma (HCC) targeting, the tumor extracellular pH-responsive lipid (2E)-4-(dioleostearin)-amino-4-carbonyl-2-butenonic (DC) for selective cellular internalization, and antitumor drug irinotecan (CPT-11)-loaded mesoporous silica nanoparticles (MSNs) for on-demand intracellular drug release. GPDC-MSNs are neg. charged at pH 7.4 and promote active HCC targeting mediated by the asialoglycoprotein receptor. Upon reaching the weakly acidic tumor microenvironment, the nanoparticles undergo charge conversion to neutral, enhancing cellular internalization. Moreover, the encapsulated CPT-11 can be retained within GPDC-MSNs in the blood circulation but undergo intracellular burst release, which facilitates the apoptosis of tumor cells. GPDC-MSNs significantly increased HCC selectivity in vivo and exhibited up to 25 times higher accumulation in tumor tissue than in normal hepatic tissue, thus achieving superior antitumor efficacy and low systemic toxicity. This stepwise-responsive nanoparticle should serve as a valuable platform and promising strategy for HCC treatment. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and biological evaluation of amide derivatives of oxazol-benzofuran-isoxazols as anticancer agents was written by Kumar, Vukoti Kiran;Puli, Venkat swamy;Prasad, Krs;Sridhar, Gattu. And the article was included in Chemical Data Collections in 2021.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

A library of amide derivatives of oxazolyl-benzofuranyl-isoxazoles I [Ar = 4-pyridyl, 4-ClC₆H₄, 3,4,5-tri-OMeC₆H₂, etc.] was designed, synthesized and their structures were characterized by spectroscopic techniques. These compounds were investigated for their in vitro anti-proliferative potential against human prostate cancer (PC3), human lung cancer (A549), human breast cancer (MCF-7) and human cervix cancer (SiHa) cancer cell lines by using of MTT assay, and the etoposide used as standard reference All compounds displayed remarkable anti-proliferative potential. Among them, compounds I [Ar = 4-pyridyl, 2-thiazolyl, 3,4,5-tri-OMeC₆H₂, 3,5-di-OMeC₆H₃] showed most promising activities than etoposide, in which one of the compound I [Ar = 3,4,5-tri-OMeC₆H₂] possessed superior activity. Further the structure-activity relationships (SARs) of these compounds were also examined In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phase Transfer and Surface Functionalization of Hydrophobic Nanoparticle using Amphiphilic Poly(amino acid) was written by Debnath, Koushik;Mandal, Kuheli;Jana, Nikhil R.. And the article was included in Langmuir in 2016.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Functionalization of nanoparticles with chem. and biochem. is essential for their biomedical and other application. However, most of the high quality nanoparticles are hydrophobic in nature due to surfactant capping and their conversion into water-soluble functional nanoparticle via appropriate coating and conjugation chem. is extremely critical issue. Here we report amphiphilic poly(amino acid)-based one-pot coating and conjugation approach that can transform hydrophobic nanoparticle into water-soluble nanoparticle functionalized with primary amine, thiol, and biomol. We have designed amphiphilic polyaspartimide that can anchor hydrophobic nanoparticle through octadecyl groups, leaving the polar polyethylene glycol and aspartimide groups exposed outwards. The aspartimide group is then reacted with primary amine containing chem./biomol. with the formation of water-soluble functional nanoparticle. This approach has been extended to different hydrophobic nanoparticles and biomols. The present approach has advantages over existing approaches as coating and functionalization can be performed in one pot and functional nanoparticles have <12 nm hydrodynamic size, high colloidal stability, and biocompatibility. This developed approach can be used to derive biocompatible nanobioconjugates for various biomedical applications. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer’s disease was written by Kurt, Belma Zengin;Gazioglu, Isil;Basile, Livia;Sonmez, Fatih;Ginex, Tiziana;Kucukislamoglu, Mustafa;Guccione, Salvatore. And the article was included in European Journal of Medicinal Chemistry in 2015.Electric Literature of C10H7BrO2 This article mentions the following:

The new benzofuranylthiazole derivatives containing the aryl-urea I [R = H, Br, NO₂; R¹ = H, 2-NO₂, 3-OCH₃, 4-CH₃, etc.] moiety were synthesized and evaluated in vitro as dual acetylcholinesterase (AChE)-butyrylcholinesterase (BuChE) inhibitors. In addition, the cupric reducing antioxidant capacities (CUPRAC) and ABTS cation radical scavenging abilities of the synthesized compounds I were assayed. The result showed that all the synthesized compounds I exhibited inhibitory activity on both AChE and BuChE with I [R = Br; R¹ = 2-F] (IC₅₀ value of 3.85 μM) and I [R = NO₂; R¹ = 4-I] (IC₅₀ value of 2.03 μM) as the strongest inhibitors against AChE and BuChE, resp. The compound I [R = NO₂; R¹ = 4-I] was 8.5-fold more potent than galanthamine. The selectivity index of I [R = Br, NO₂; R¹ = 2-F, 4-I] was 2.40 and 0.37 against AChE and BuChE, resp. The compound I [R = H; R¹ = 3-OCH₃, 4-CH₃, 4-F] (IC₅₀ = 0.2, 0.5 and 1.13 μM, resp.) showed a better ABTS cation radical scavenging ability than the standard quercetin (IC₅₀ = 1.18 μM). Best poses of compounds I [R = NO₂; R¹ = 4-I] on BuChE and I [R = Br; R¹ = 2-F] on AChE indicate that the thiazole ring and the amidic moiety are important sites of interaction with both ChEs. In addition, the benzofuran ring and Ph ring are anchored to the side chains of both enzymes by π-π interactions. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Labeling of nucleosides with fluorescamine and detection by spectrofluorometer for End Stage Renal Disease was written by Jamal, Shubi;Agrawal, Y. K.. And the article was included in Saudi Journal of Biological Sciences in 2013.Synthetic Route of C17H10O4 This article mentions the following:

Nucleosides are characterized as biomarkers in AIDS, Alzheimer, tumor, breast cancer and various malignant diseases. In the present work a direct method for the detection of nucleosides (adenosine, cytidine, uridine and guanosine) from urine samples has been developed. Nucleosides represent the extent of damage in genetic material, anal. of nucleosides by ultrasonic assisted microextraction effectively eliminates the interfering constituent of urine. This has made it a highly selective and sensitive method to analyze the nucleosides with a lower limit of detection 0.220 μmol/L and Limit of quantitation 0.660 μmol/L. The method has been validated with good linearity and correlation of coefficients of the calibration curves was higher than 0.997. The coefficients were in the range of 0.11-16.92% (inter-day) and 0.38-16.43% (intra-day), resp. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Spectrofluorimetric determination of aliskiren in dosage forms and urine was written by Aydogmus, Zeynep. And the article was included in Luminescence in 2012.Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

A new, simple, and sensitive spectrofluorimetric method was developed for the determination of aliskiren (ALS) in dosage forms and human urine. The method is based on the reaction between ALS and fluorescamine in borate buffer solution, pH 9, to give a highly fluorescent derivative which is measured at 482 nm after excitation at 382 nm. The factors affecting the reaction were carefully studied. The fluorescence intensity concentration plots were rectilinear over the range 140-1400 ng/mL with a limit of detection 13.47 ng/mL and limit of quantitation 40.81 ng/mL. The developed method was successfully applied to the anal. of the drug in tablets and human urine; the average recoveries (n = 6) were 99.88 ± 0.38% and 99.57 ± 0.44%, resp. The anal. performance of the method was fully validated and the results were satisfactory. The stability of the drug was studied by subjecting it to acidic, basic, oxidative and thermal degradation Copyright © 2012 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Natural peptide anti-glycation effect in the presence of Aloe vera phenolic components on human serum albumin was written by Moosavi-Movahedi, Ali Akbar;Ghamari, Fatemeh;Ghaffari, Seyed Mahmoud;Salami, Maryam;Farivar, Farzaneh;Moosavi-Movahedi, Faezeh;Johari, Anahita;Aminin, Agustina L. N.. And the article was included in RSC Advances in 2015.COA of Formula: C17H10O4 This article mentions the following:

The Maillard reaction, non-enzymic glycation after a complex series of reactions that involve reducing-sugars and proteins, produces a large number of end-products that are known as advanced glycation end-products (AGEs). AGEs are related to the pathogenesis of many diseases such as diabetes, inflammatory arthritis and cataracts. Today there is an increasing demand for natural AGE inhibitors for curing diabetes that have fewer side effects compared to synthetic drugs. The aim of this study was to explore the anti-glycation effect of aloin, in the presence and absence of casein-derived peptides, on human serum albumin (HSA). UV-visible and fluorescence spectroscopy were used to explore the number of free lysine residues, AGE formation and fibril formation during the HSA glycation. According to trinitrobenzenesulfonic acid and fluorescamine assay results, the presence of aloin and peptides reduced the number of glucose-attached lysine residues. Moreover AGE specific fluorescence and thioflavin T fluorescence decreased in the presence of aloin and peptides, indicative of a decrease in the formation of AGEs and fibrils resp. during the glycation of HSA. According to this study, aloin and camel casein derived peptides showed a synergic anti-glycation effect and inhibited the formation of fibrils and AGEs during the HSA glycation. This effect can be related to the antioxidant activity of aloin-peptide complex. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem