Design, synthesis and biological evaluation of amide derivatives of oxazol-benzofuran-isoxazols as anticancer agents was written by Kumar, Vukoti Kiran;Puli, Venkat swamy;Prasad, Krs;Sridhar, Gattu. And the article was included in Chemical Data Collections in 2021.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:
A library of amide derivatives of oxazolyl-benzofuranyl-isoxazoles I [Ar = 4-pyridyl, 4-ClC6H4, 3,4,5-tri-OMeC6H2, etc.] was designed, synthesized and their structures were characterized by spectroscopic techniques. These compounds were investigated for their in vitro anti-proliferative potential against human prostate cancer (PC3), human lung cancer (A549), human breast cancer (MCF-7) and human cervix cancer (SiHa) cancer cell lines by using of MTT assay, and the etoposide used as standard reference All compounds displayed remarkable anti-proliferative potential. Among them, compounds I [Ar = 4-pyridyl, 2-thiazolyl, 3,4,5-tri-OMeC6H2, 3,5-di-OMeC6H3] showed most promising activities than etoposide, in which one of the compound I [Ar = 3,4,5-tri-OMeC6H2] possessed superior activity. Further the structure-activity relationships (SARs) of these compounds were also examined In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem