Tag: 200-300

Romero, Maria P; Buzza, Hilde H; Stringasci, Mirian D; Estevão, Bianca M; Silva, Cecilia C C; Pereira-da-Silva, Marcelo A; Inada, Natalia M; Bagnato, Vanderlei S published their research in International journal of nanomedicine in 2021. The article was titled 《Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration.》.Application of 5471-63-6 The article contains the following contents:

INTRODUCTION: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy. METHODS: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2). RESULTS: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT. DISCUSSION: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Generation and Reactivity of a NiIII2(μ-1,2-peroxo) Complex》 was written by Zhao, Norman; Filatov, Alexander S.; Xie, Jiaze; Hill, Ethan A.; Rogachev, Andrey Yu.; Anderson, John S.. HPLC of Formula: 5471-63-6 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

High-valent transition metal-oxo, -peroxo, and -superoxo complexes are crucial intermediates in both biol. and synthetic oxidation of organic substrates, water oxidation, and oxygen reduction While high-valent oxygenated complexes of Mn, Fe, Co, and Cu are increasingly known, high-valent oxygenated Ni complexes are comparatively rarer. Herein authors report the isolation of such an unusual high-valent species in a thermally unstable NiIII2(μ-1,2-peroxo) complex, which was characterized using single-crystal x-ray diffraction and x-ray absorption, NMR, and UV-visible spectroscopies. Reactivity studies show that this complex is stable toward dissociation of oxygen but reacts with simple nucleophiles and electrophiles.1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photophysical and electrochemical properties of two trans-A2B-corroles: differences between phenyl or pyrenyl groups at the meso-10 position》 was written by Acunha, Thiago V.; Victoria, Henrique F. V.; Krambrock, Klaus; Marques, Amanda C.; Costa, Luiz Antonio S.; Iglesias, Bernardo A.. Quality Control of 1,3-Diphenylisobenzofuran And the article was included in Physical Chemistry Chemical Physics in 2020. The article conveys some information:

The present study reported on the optical and photophys. properties of trans-A2B-corroles possessing pyrenyl units attached at the meso-10-position and compares them with those of model trans-A2B-corroles having Ph substituents at that position. In contrast to the model meso-substituted corrole, the new pyrenyl-corrole showed slightly red-shifted absorption bands and blue-shifted emission, slightly higher fluorescence quantum yield, and more importantly, it showed better photo-stability under white-light illumination. Theor. calculations were used to determine the electronic transitions and geometries of the singlet and triplet excited states (TD-DFT and NTO). Moreover, we demonstrated that the pyrenyl-corrole in analogy to previously studied model corroles was able to generate reactive oxygen species (ROS) under visible light using photo-degradation of 1,3-diphenylisobenzofuran (DBPF), a singlet oxygen quencher, and EPR spectroscopy allied with the spin-trapping method was used for identifying singlet oxygen species. The results showed that the pyrenyl unit attached at the meso-10-position of the corrole increased the photo-stability and efficiency in ROS generation compared to the Ph substituent.1,3-Diphenylisobenzofuran(cas: 5471-63-6Quality Control of 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Quality Control of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The author of 《Chemistry of the “”insoluble red”” woods. I. Pterocarpin and homopterocarpin》 were McGookin, Alexander; Robertson, Alexander; Whalley, Wm. B.. And the article was published in Journal of the Chemical Society in 1940. Synthetic Route of C12H12O4 The author mentioned the following in the article:

Owing to the insoluble nature of their coloring matters in warm H2O, red sandalwood, camwood, barwood and narrawood have been classified as “”insoluble red”” woods to distinguish them from the “”soluble red”” woods of the logwood type. Since these woods invariably contain the colorless constituents pterocarpin (I) and homopterocarpin (II), they have been studied as an approach to the structure of the dyes. Finely powd. barwood (Baphia nitida Lodd) (300 g.), extracted with 2.5 l. boiling CCl4 for 6 h., the filtered extract concentrated to 37-40 cc. at a temperature not above 50°, 1.5 g. of red solid filtered off, the viscous red liquid dissolved in 20 cc. 96% alc. and the precipitate which seps. fractionally crystallized from 96% EtOH, give 0.15 g. I and 1 g. II, C17H16O4, m. 87°, [α]546120.5 -236.6° (CHCl3, c 0.898 g. in 100 cc.) (cf. Leonhardt and Oechler, C. A. 30, 1372.1). II sublimes unchanged at 80°/0.1 mm. II is extremely sensitive to mineral acids and is stable to boiling EtOH-NaOH; HO or CO groups could not be detected. Oxidation of II with KMnO4 in aqueous Me2CO gives a mixture of 5,2-MeO(HO2C)C6H3OCH2CO2H (IIA) and 2,4-HO(MeO)C6H3CO2H (IIB), indicating the presence of an O-mono-Me resorcinol nucleus and of the system -C.O.CH2C- in II. Catalytic reduction of II in EtOH or AcOH with Pd-C gives l-dihydrohomopterocarpin (III), R = 2,4-HO(MeO)C6H3, m. 154°, [α]546120 -12.7° (EtOH, c 0.295); this is also formed by the Clemmensen reduction of II; the Me ether (IV) m. 61° (cf. Dieterle and L., C. A. 23, 2245). Oxidation of III with CrO3 in AcOH gives dihydrohomopterocarpone (V), orange, m. 177.5-8.5°; oxime, m. 229°. KMnO4 oxidation of III in Me2CO gives 7-methoxy-3-chromancarboxylic acid (VI), m. 149°; the yellow concentrated H2SO4 solution exhibits a brilliant green fluorescence. Reduction of V with Zn and AcOH gives the quinol(?), m. 145°. Oxidation of IV with KMnO4 in Me2CO gives an isoflavanone (VII), R = 2,4-(MeO)2C6H3, m. 127° (oxime, m. 185.5°; 2,4-dinitrophenylhydrazone, red, m. 184°); further oxidation of VII in 2 N NaOH with KMnO4 gives a compound, C15H9O3(OMe)3(?), m. 178°. The 4′-position for the MeO group in III is preferred, although it has not been definitely established. I m. 164.5° [α]546120.5 -207.5° (CHCl3, c 0.530). Hydrogenation of I in AcOH with Pd-C gives a dihydro derivative (VIII), m. 140°, [α]546121 -19.5° (EtOH, c 1.714), which also results on Clemmensen reduction of I; Me ether (IX), m. 106.5°. Oxidation of I with KMnO4 in aqueous Me2CO gives a mixture of IIA and IIB, with a small amount of a neutral product, m. 272°. VIII gives VI with KMnO4 in aqueous Me2CO and with CrO8 in AcOH there results a yellow resinous product which with 2,4-(O2N)2C6H3NHNH2 gives a compound, C23H18O10N4, maroon, m. 202-3° (decomposition). KMnO4 oxidation of IX yields a ketone, C16H10O4(OMe)2, m. 118-19°, whose 2,4-dinitrophenylhydrazone, scarlet, m. 248°. Thus, I appears to differ from II in having a methylenedioxy group. 4-O-Methyl-β-resorcylaldehyde in 8% aqueous KOH, added to ClCH2CH2CO2H in aqueous NaHCO3, gives β-(5-methoxy-2-formylphenoxy)propionic acid, m. 159°; 2,4-dinitrophenylhydrazone, m. 241.5°; semicarbazone, m. 218° (decomposition); oxidation with alk. KMnO4 gives β-(5-methoxy-2-carboxyphenoxy)propionic acid, m. 143°; Me ester, b95 78-80°. The acid, Ac2O and AcONa, refluxed 1 h. at 145°, give 7-methoxy-Δ3-chromene-3-carboxylic acid, m. 201°; the yellow concentrated H2SO4 has an intense green fluorescence; catalytic reduction gives VI. 2,5-OHC(MeO)C6H3OCH2CO2Et gives a 2,4-dinitrophenylhydrazone, crimson, m. 176.5°; cyclization of the ester with EtONa in EtOH gives Et 6-methoxy-2-coumaronecarboxylate (X), m. 87°; it gives a cherry-red and then a purple H2SO4 reaction; acidification of the alk. liquor gives 2,5-OHC(MeO)C6H3OCH2CO2H, yielding a 2,4-dinitrophenylhydrazone, light red, m. 273°. The free acid from X m. 206°, having a crimson and then a brilliant purple H2SO4 reaction; PCl5 in CHCl3 gives the acid chloride (XI), b15 165°, m. 101°. XI in absolute ether at -10° with anhydrous HCN and a mixture of C5H5N and ether gives the nitrile, pale yellow, b1.5 162°, m. 101°; this could not be converted into the corresponding pyruvic acid. XI and CH2N2 in ether give the diazoketone, pale yellow, m. 90-1° (slight decomposition); with NH4OH and AgNO3 in dioxane there results the amide, m. 148°, of 6-methoxy-2-coumaroneacetic acid, m. 104°. In addition to this study using Ethyl 6-methoxybenzofuran-2-carboxylate, there are many other studies that have used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Synthetic Route of C12H12O4) was used in this study.

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Synthetic Route of C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C20H14OIn 2021 ,《Conferring Ti-Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy》 was published in Advanced Materials (Weinheim, Germany). The article was written by Liang, Shuang; Xiao, Xiao; Bai, Lixin; Liu, Bin; Yuan, Meng; Ma, Ping’an; Pang, Maolin; Cheng, Ziyong; Lin, Jun. The article contains the following contents:

The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, a defect-rich Ti-based metal-organic framework (MOF) (D-MOF(Ti)) with greatly improved sonosensitizing effect is simply constructed and used for enhanced SDT. Compared with the commonly used sonosensitizer TiO2, D-MOF(Ti) results in a superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves the US-triggered electron-hole separation Meanwhile, due to the existence of Ti3+ ions, D-MOF(Ti) also exhibits a high level of Fenton-like activity to enable chemodynamic therapy. Particularly, US as the excitation source of SDT can simultaneously enhance the Fenton-like reaction to achieve remarkably synergistic outcomes for oncotherapy. More importantly, D-MOF(Ti) can be degraded and metabolized out of the body after completion of its therapeutic functions without off-target toxicity. Overall, this work identifies a novel Ti-familial sonosensitizer harboring great potential for synergistic sonodynamic and chemodynamic cancer therapy. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of 1,3-DiphenylisobenzofuranIn 2021 ,《A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy》 was published in Advanced Materials (Weinheim, Germany). The article was written by Liang, Shuang; Liu, Bin; Xiao, Xiao; Yuan, Meng; Yang, Ling; Ma, Ping’an; Cheng, Ziyong; Lin, Jun. The article contains the following contents:

The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4) nanodendrites with a narrower bandgap (compared with the most extensively explored sonosensitizers) are presented as a new source of sonosensitizer, which allows a more effortless separation of sono-triggered electron-hole pairs for ROS generation. Specifically, platinum (Pt) nanoparticles and endogenous high levels of glutathione (GSH) are rationally engineered to further optimize its sono-sensitized performance. As cocatalyst, Pt is conducive to trapping electrons, whereas GSH, as a natural hole-scavenger, tends to capture holes. Compared with the pristine VS4 sonosensitizer, the GSH-Pt-VS4 nanocomposite can greatly prolong the lifetime of the charge and confer a highly efficacious ROS production activity. Furthermore, such nanoplatforms are capable of reshaping tumor microenvironments to realize ROS overproduction, contributed by overcoming tumor hypoxia to improve SDT-triggered singlet oxygen production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals for chemodynamic therapy, and depleting GSH to amplify intratumoral oxidative stress. All these combined effects result in a significantly efficient tumor suppression outcome. This study enriches sonosensitizer research and proves that sonosensitizers can be rationally optimized by charge separation engineering strategy. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Quality Control of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Quality Control of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 5471-63-6In 2021 ,《Porous polymers from octa(amino-phenyl)silsesquioxane and metalloporphyrin as peroxidase-mimicking enzyme for malathion colorimetric sensor》 appeared in Colloids and Surfaces, B: Biointerfaces. The author of the article were Guo, Xiaojun; Chen, Mohan; Jing, Lu; Li, Jie; Li, Yanhong; Ding, Rui; Zhang, Xiaomei. The article conveys some information:

Rapid and efficient pesticide detection methods are particularly important due to the growing problems of pesticide residues. Here, a new azo-based porous organic polymer, Azo(Fe)PPOP, was prepared from octa(amino-phenyl)silsesquioxane (OAPS) and iron(III) 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (FeTPP(NO2)4) via a simple coupling reaction without the participation of metal catalysts. The inorganic cage units of OAPS endowed Azo(Fe)PPOP a porous framework, high surface area, favorably thermal and chem. stability. In Azo(Fe)PPOP, iron(III) porphyrin units were individually isolated in a fixed location, which could effectively avoid dimerization or self-oxidation as happens as in the case of porphyrin monomers. Such a unique structure made Azo(Fe)PPOP exhibit an excellent peroxidase-like catalytic performance in the presence of H2O2 and 3,3′,5,5′-tetramethylbenzidine (TMB). Because of these advantages, we established a selective, facile, and sensitive colorimetric platform for direct detection of malathion within a very short time (3 min) with a low detection limit (8.5 nM). In addition, the recognition mechanism between Azo(Fe)PPOP and malathion was verified using XPS spectra. The practicality of the constructed platform was further executed by the detection of the pesticide in soil and food samples. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Loukhina, I. V.; Gradova, M. A.; Khudyaeva, I. S.; Lobanov, A. V.; Belykh, D. V. published their research in Russian Journal of General Chemistry in 2021. The article was titled 《Synthesis and photocatalytic properties of magnesium silicate modified with cationic chlorin e6 derivatives》.Electric Literature of C20H14O The article contains the following contents:

Synthetic samples of layered magnesium silicate modified with mono-, di-, and tricationic chlorin e6 derivatives have exhibited comparable photochem. activity towards a series of reductants: 1,3-diphenylisobenzofuran selectively oxidizable with singlet oxygen and 1,2-phenylenediamine readily oxidizable with hydrogen peroxide. The optimal photochem. activity of the modified magnesium silicates has been achieved at the ratio of 4-8 μmol of chlorin e6 derivative per 1 g of magnesium silicate. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Capture and Release of Singlet Oxygen in Coordination-Driven Self-Assembled Organoplatinum(II) Metallacycles》 was published in Journal of the American Chemical Society in 2020. These research results belong to He, Yan-Qin; Fudickar, Werner; Tang, Jian-Hong; Wang, Heng; Li, Xiaopeng; Han, Jun; Wang, Zhengping; Liu, Min; Zhong, Yu-Wu; Linker, Torsten; Stang, Peter J.. COA of Formula: C20H14O The article mentions the following:

Singlet oxygen (1O2), as an important active reagent, has found wide applications in photodynamic therapy (PDT), synthetic chem., and materials science. Organic conjugated aromatics serving as hosts to capture and release singlet oxygen have been systematically investigated over the last decades. Herein, we present a [6 + 6] organoplatinum(II) metallacycle by using ∼180° dipyridylanthracene donor and ∼120° Pt(II) acceptor as the building blocks, which enables the capture and release of singlet oxygen with relatively high photooxygenation and thermolysis rate constants The photooxygenation of the metallacycle to the corresponding endoperoxide was performed by sensitized irradiation, and the resulting endoperoxide is stable at room temperature and can be stored under ambient condition over months. Upon simple heating of the neat endoperoxide under inert atm. at 120°C for 4 h, the resulting endoperoxide can be reconverted to the corresponding parent form and singlet oxygen. The photooxygenation and thermolysis products were characterized by NMR spectroscopy and electrospray ionization time-of-flight mass spectrometric anal. D. functional theory calculations were conducted in order to reveal the frontier MO interactions and reactivity. This work provides a new material platform for singlet oxygen related promising applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xue, Si-tu; Zhang, Lei; Xie, Zhuo-song; Jin, Jie; Guo, Hui-Fang; Yi, Hong; Liu, Zong-ying; Li, Zhuo-rong published their research in European Journal of Medicinal Chemistry on August 15 ,2020. The article was titled 《Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model and ADME properties》.Computed Properties of C12H12O4 The article contains the following contents:

This study optimized the structure of the anti-osteoporosis compound I [R1 = H; R2 = OMe; R5 = OEt; X = O] by balancing its lipophilicity and improving its stability. Substituted benzothiophenes/benzofurans derivatives I [R1 = H; R2 = OMe; R1R2 = OCH2O; R5 = Cl, OH, OEt; X = O, S] and II [R1 = H; R2 = OMe; R1R2 = OCH2O; R3 = n-Pr, P(O)(OH)2, CH2N(CH3)2, etc.; X = O, S; Y = O, NH, NMe] which were not reported in the literature were designed and synthesized. The ovariectomized rat model of osteoporosis was selected to evaluate the therapeutic effects, compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] showed better therapeutic efficacy than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. The anti-osteoporosis activity and BMP-2 (bone morphogenetic protein-2) protein upregulation after treatment with compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] in a zebrafish osteoporosis model was verified. Compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] improved the ADME properties, therapeutic efficacy and pharmacokinetics of the drug than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. Overall, the anti-osteoporosis effects of the compounds I and II of this type, preliminarily determined the target patient population, verified the mechanism of action, clarified the level of toxicity and provided preliminary ADME data was evaluated. These compounds I and II could both correct bone loss that was already occurring in patients and had broad clin. applicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Computed Properties of C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Computed Properties of C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem