Tag: 200-300

Madridejos, Jenica Marie L.; Harada, Takaaki; Falcinella, Alexander J.; Small, Thomas D.; Golovko, Vladimir B.; Andersson, Gunther G.; Metha, Gregory F.; Kee, Tak W. published an article in 2021. The article was titled 《Optical Properties of the Atomically Precise C4 Core [Au9(PPh3)8]3+ Cluster Probed by Transient Absorption Spectroscopy and Time-Dependent Density Functional Theory》, and you may find the article in Journal of Physical Chemistry C.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Structural isomerism of [Au9(PPh3)8]3+ has been studied exptl., mostly concerning the symmetry of the Au9 core. Recently, the C4 isomer of [Au9(PPh3)8]3+ has been shown to exist in solution phase while the D2h isomer is present in the solid state [Inorganic Chem.2017, 56, 8319-8325]. In this work, geometric, electronic, and optical properties of C4 [Au9(PPh3)8]3+ are investigated by using the combined second-order d.-functional tight-binding (DFTB2) method and time-dependent d. functional theory (TD-DFT) calculations with spin-orbit coupling. Addnl., the excited-state relaxation dynamics of the [Au9(PPh3)8]3+ cluster in dichloromethane and methanol solutions are studied using femtosecond transient absorption spectroscopy. [Au9(PPh3)8]3+ is optically pumped to different excited states by using 432, 532, and 603 nm light. For all three pump wavelengths, the photoexcitation event induces an excited-state absorption (ESA) band centered at 600 nm with decay time constants of 2.0 and 45 ps, which are attributed to intersystem crossing and nonradiative relaxation of [Au9(PPh3)8]3+, resp. On the other hand, optical pumping of [Au9(PPh3)8]3+ using 432 nm light gives rise to an addnl. ESA band at 900 nm. This band exhibits fast relaxation through internal conversion with a time constant of ~0.3 ps. Our combined computational and exptl. study reveals that the excitation wavelength-dependent relaxation dynamics of the [Au9(PPh3)8]3+ cluster are related to the different electron densities of the excited states of [Au9(PPh3)8]3+, consistent with it possessing mol.-like electronic states. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Xiang; Wang, Ran; Hu, Yingqi; Liu, Wei Jian; Liu, Ting; Sun, Wen; Fan, Jiangli; Peng, Xiaojun published an article in 2021. The article was titled 《A novel photosensitizer for lipid droplet-location photodynamic therapy》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biol. processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet-targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging-guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet-location PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photocatalytic degradation of tetracycline by a novel (CMC)/MIL-101(Fe)/β-CDP composite hydrogel》 was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2020. These research results belong to Zhang, Hui; Zhou, Liang; Li, Jing; Rong, Sijia; Jiang, Jianping; Liu, Shengquan. Computed Properties of C20H14O The article mentions the following:

Herein, we report a novel CM-cellulose (CMC)/MIL-101 (Fe)/poly(β-cyclodextrin) (β-CDP) hydrogel with high photocatalytic activity. β-CDP can significantly enhance the photoactivity of MIL-101(Fe) in the hydrogel prepared by a simple solvothermal method. The structure and property of this composite hydrogel were characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, and transmission electron microscopy. Tetracycline was selected as a model pharmaceutical antibiotic to evaluate the photocatalytic activity of the composite hydrogel under visible light irradiation and darkness, resp. This composite hydrogel shows excellent activity for degrading pharmaceutical antibiotics under visible light irradiation The increased photocatalytic activity can be attributed to β -CDP, which acts as a promoter and affords an efficient separation of photogenerated electron-hole pairs of MIL-101(Fe). Moreover, the composite hydrogel is shown to have good water retainability. The hydrogel is inexpensive and shows high photocatalytic activity. Hence, it can be used as an efficient photocatalytic material.1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C20H14OIn 2020 ,《Post-synthetically elaborated BODIPY-based porous organic polymers (POPs) for the photochemical detoxification of a sulfur mustard simulant》 appeared in Journal of the American Chemical Society. The author of the article were Atilgan, Ahmet; Cetin, M. Mustafa; Yu, Jierui; Beldjoudi, Yassine; Liu, Jian; Stern, Charlotte L.; Cetin, Furkan M.; Islamoglu, Timur; Farha, Omar K.; Deria, Pravas; Stoddart, J. Fraser; Hupp, Joseph T.. The article conveys some information:

Designing new materials for the effective detoxification of chem. warfare agents (CWAs) is of current interest given the recent use of CWAs. Although halogenated boron-dipyrromethene derivatives (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene or BDP or BODIPY) at the 2 and 6 positions have been extensively explored as efficient photosensitizers for generating singlet oxygen (1O2) in homogeneous media, their utilization in the design of porous organic polymers (POPs) has remained elusive due to the difficulty of controlling polymerization processes through cross-coupling synthesis pathways. Our approach to overcome these difficulties and prepare halogenated BODIPY-based porous organic polymers (X-BDP-POP where X = Br or I) represents an attractive alternative through post-synthesis modification (PSM) of the parent hydrogenated polymer. Upon synthesis of both the parent polymer, H-BDP-POP, and its post-synthetically modified derivatives, Br-BDP-POP and I-BDP-POP, the BET surface areas of all POPs have been measured and found to be 640, 430, and 400 m2·g-1, resp. In addition, the insertion of heavy halogen atoms at the 2 and 6 positions of the BODIPY unit leads to the quenching of fluorescence (both polymer and solution-phase monomer forms) and the enhancement of phosphorescence (particularly for the iodo versions of the polymers and monomers), as a result of efficient intersystem crossing. The heterogeneous photocatalytic activities of both the parent POP and its derivatives for the detoxification of the sulfur mustard simulant, 2-chloroethyl Et sulfide (CEES), have been examined; the results show a significant enhancement in the generation of singlet oxygen (1O2). Both the bromination and iodination of H-BDP-POP served to shorten by 5-fold of the time needed for the selective and catalytic photo-oxidation of CEES to 2-chloroethyl Et sulfoxide (CEESO). The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of 1,3-DiphenylisobenzofuranIn 2021 ,《Singlet fission in covalent dimers of methylene-locked 1,3-diphenyl-isobenzofuran: semiclassical simulations of nonadiabatic dynamics》 was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability. The article was written by Accomasso, Davide; Granucci, Giovanni; Persico, Maurizio. The article contains the following contents:

We present surface hopping simulations of the nonadiabatic dynamics in three covalently bound dimers of the methylene-locked 1,3-diphenylisobenzofuran (ML-DPBF) chromophore, a modification of a mol. previously studied exptl. and computationally by Michl et al. (J. C. Johnson and J. Michl, Top. Curr. Chem. (Z), 2017, 375, 80). Our aim is to test the suitability for singlet fission of such dimers, as well as to study how the singlet fission dynamics is affected by the mutual arrangement of chromophores in the covalent assembly. Two of our investigated covalent dimers, namely D1 and D2, are newly designed dimers in which the chromophores are linked by two bridges so as to attain suitable stacking arrangements, while the third one (D0) is a linear dimer in which one -CH2- bridge connects the two chromophore units. From our simulations it turned out that D1 and D2 undergo singlet fission in a sub-picosecond time scale. The final populations of the double triplet state (TT) are large (0.74 and 0.84, resp.), but do not reach the limiting value of 1 because of a persistent exchange with the lowest dark excitonic state. On the other hand, our simulations for D0 indicate that this dimer does not undergo singlet fission in the 4 ps following the photoexcitation, mainly because of the weak interaction between chromophores. Our study, besides indicating the potential suitability for singlet fission of dimers D1 and D2, highlights the impact of the mutual arrangement of chromophores in determining the singlet fission efficiency. In fact, we show the importance of fine tuning not only the effective couplings that permit to populate the TT state, but also the exciton splitting of the lowest singlet states. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Carbon quantum dots embedded electrospun nanofibers for efficient antibacterial photodynamic inactivation》 was written by Nie, Xiaolin; Wu, Shuanglin; Mensah, Alfred; Lu, Keyu; Wei, Qufu. Synthetic Route of C20H14O And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020. The article conveys some information:

Faced with the emergence and proliferation of antibiotic resistant pathogens, novel nonspecific materials and approaches are required. Herein, we employed electrospinning technol. to fabricate nanofibers with antibacterial photodynamic inactivation. This material combines polyacrylonitrile, as a photostable polymer, and biocompatible carbon quantum dots. The resulted nanofibers were successfully characterized by phys. and spectroscopic methods. The microbicidal reactive oxygen species (i.e., singlet oxygen) upon illumination was confirmed, and cytotoxicity assay demonstrated that the nanofibers had low cytotoxicity and good biocompatibility. Antibacterial photodynamic inactivation studies demonstrated broad antibacterial efficacy of Gram-neg. Escherichia coli ATCC-8099 (99.9999+%, 6 log units inactivation), Gram-neg. Pseudomonas aeruginosa CMCC (B) 10104 (99.9999+%, 6 log units inactivation), and Gram-pos. Bacillus subtilis CMCC (B) 63501 (99.9999+%, 6 log units inactivation) upon illumination with visible light (Xe lamp, 500 W, 12 cm sample distance). However modest inactivation results were observed against Gram-pos. Staphylococcus aureus ATCC-6538 (98.3%, 1.8 log units inactivation). Owing to the prepared nanofibers exhibiting efficient antibacterial activity against Gram-neg. and Gram-pos. bacteria, such materials could be potentially used in anti-infective therapy. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rehman, Mehreen; Raza, Abida; Khan, Jamshaid Ali; Zia, M. Aslam published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Laser Responsive Cisplatin-Gold Nano-Assembly Synergizes the Effect of Cisplatin With Compliance》.Formula: C20H14O The article contains the following contents:

Cisplatin therapy faces low bioavailability and clastogenic potential limitations. Early payload leakage of nanocarriers may impair adequate therapeutic efficacy. We propose encapsulation of cisplatin in such nanocarrier that can be externally stimulated for high payload release and enhanced toxicity at site of action. Cisplatin conjugated gold nanorods (Pt-AuNRs) have been synthesized and characterized through UV visible spectroscopy, dynamic light scattering and transmission electron microscopy. Physico-chem. characterization through X-ray photon spectrometry confirms the covalent linkage between linker and aquated cisplatin with AuNRs. Laser exposure (850 nm, CW) enabled ∼15-fold payload release from Pt-AuNRs nano-assembly, which is quite high (P < 0.0001) compared to non-stimulated conditions. The median growth inhibitory concentration (GI50) after laser exposure of Pt-AuNRs was ∼11- and 13-fold low compared to corresponding Pt-AuNRs without laser exposure and cisplatin resp., in sarcoma cells. Synergistic therapeutic difference is more significant (P < 0.01), at lower concentrations of Pt-AuNRs (0.5-10μg/mL). Pt-AuNRs photothermal therapy indicates a convincible association of over-production of reactive oxygen species (P < 0.0001) and synergistic therapeutic efficacy. Clastogenic potential is found non-significant for Pt-AuNRs (10μg/mL). Cisplatin nanoconjugate shows biocompatibility against blood cells. In conclusion, laser-stimulated Pt-AuNRs appear a promising drug delivery with synergistic toxic potential against cancer while attenuating cisplatin toxicity. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Crystal structure of dimethyl 5-(4-ethylphenyl)-4-[(4-ethylphenyl)ethynyl]-6,11-diphenyl-1,3,6,11-tetrahydro-2H-6,11-epoxycyclopenta[a]anthracene-2,2-dicarboxylate》 was published in Acta Crystallographica, Section E: Crystallographic Communications in 2020. These research results belong to Meng, Xiang-Zhen; Cheng, Dong. COA of Formula: C20H14O The article mentions the following:

In the central fused ring system of the title compound, C51H42O5, all of the five-membered rings are in an envelope conformation. The dihedral angle between the two benzene rings in the fused ring system is 74.66 (7)°. In the crystal, mols. are linked by C-H···π interactions, forming a layer parallel to the ab plane. Each mol. acts as a double donor as well as a double acceptor of the C-H···π interactions. Hirshfeld surface anal. and two-dimensional fingerprint plots indicate that the most important contributions to the crystal packing are from H···H (61.4%) and C···H/H···C (25.3%) contacts. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yin, Juanjuan; Jiang, Xu; Sui, Guomin; Du, Yingying; Xing, Enyun; Shi, Ruijie; Gu, Chengzhi; Wen, Xiaona; Feng, Yaqing; Shan, Zhongqiang; Meng, Shuxian published an article in 2021. The article was titled 《The tumor phototherapeutic application of nanoparticles constructed by the relationship between PTT/PDT efficiency and 2,6- and 3,5-substituted BODIPY derivatives》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

BODIPY dyes have recently been used for photothermal and photodynamic therapy of tumors. However, complex multi-material systems, multiple excitation wavelengths and the unclear relationship between BODIPY structures and their PTT/PDT efficiency are still major issues. In our study, nine novel BODIPY near-IR dyes were designed and successfully synthesized and then, the relationships between BODIPY structures and their PTT/PDT efficiency were investigated in detail. The results showed that modifications at position 3,5 of the BODIPY core with conjugated structures have better effects on photothermal and photodynamic efficiency than the modifications at position 2,6 with halogen atoms. D. functional theory (DFT) calculations showed that this is mainly due to the extension of the conjugated chain and the photoinduced electron transfer (PET) effect. By encapsulating BDPX-M with amphiphilic DSPE-PEG2000-RGD and lecithin, the obtained NPs not only show good water solubility and biol. stability, but also could act as superior agents for photothermal and photodynamic synergistic therapy of tumors. Finally, we obtained BODIPY NPs that exhibited excellent photothermal and photodynamic effects at the same time under single irradiation with an 808 nm laser (photothermal conversion efficiency: 42.76%, A/A0: ~0.05). In conclusion, this work provides a direction to design and construct phototherapeutic nanoparticles based on BODIPY dyes for tumor treatment. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhou, Junli; Li, Yite; Wang, Lei; Xie, Zhigang published an article in 2021. The article was titled 《Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.Product Details of 5471-63-6 The information in the text is summarized as follows:

Photoactive MOF-based delivery systems are highly attractive for photodynamic therapy (PDT), but the fundamental interplay among structural parameters and photoactivity and biol. properties of these MOFs remains unclear. Herein, porphyrinic MOF isomers (TCPP-MOFs), constructing using the same building blocks into distinct topologies, have been selected as ideal models to understand this problem. Both the intramol. distances and mol. polarization within TCPP-MOFs isomers collectively contribute to the photoactivity of generating reactive oxygen species. Remarkably, the morphol.-determined endocytic pathways and cytotoxicity, as well as good biocompatibility have been confirmed for TCPP-MOF isomers without any chem. modification for the first time. Besides the topol.-dependent photoactive regulation, this work also provides in-depth insights into the biol. effect from the MOF nanoparticles with controllable structural factors, benefiting further in vivo applications and clin. transformation. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Product Details of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Product Details of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem