With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82104-74-3,1-Oxo-1,3-dihydroisobenzofuran-5-carbonitrile,as a common compound, the synthetic route is as follows.
82104-74-3, A solution of 4-fluorophenyl magnesium bromide prepared from 153.33g 4- fluorol bromobenzene (0.876 moles), 25.33g magnesium turnings (1.055 moles) and 0.05g iodine in dry 300ml tetrahydrofuran, was added to a suspension of 100g 5-cyanophthalide (0.628 moles) in 1000ml methylene dichloride at-6 to-2¡ãC. After the reaction was completed, the reaction mass was quenched with 100ml 20percent aqueous ammonium chloride solution. The organic layer was separated and diluted with 100ml of methanol. Slowly, 12g of sodium borohydride (0. 324moles) was added over a period of one hour at below 25¡ãC, and the same temperature was maintained for 4-6 hours. The mixture was then cooled to 5-10¡ãC, maintained for 2 hours and then the precipitated boron complex VB solid was filtered. The solid was washed with chilled dichloromethane and dried under vacuum below 40¡ãC to provide pure boron complex. Weight: 115-120g HPLC purity: 98-99percent
As the paragraph descriping shows that 82104-74-3 is playing an increasingly important role.
Reference£º
Patent; JUBILANT ORGANOSYS LIMITED; WO2005/66185; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem