With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
The 2-(thiophen-2-yl) acetonitrile (1 g, 8.118mmole), benzofuran-2-carbaldehyde (1.2 g, 8.118 mmol), and 2 g ofNaOH were dissolved in 45 ml of ethanol. Then, these reactionmixtures were stirred vigorously at normal room temperature for24 h. The improvement of the reactionwas monitored by TLC. Aftercompletion of the reaction, the mixtures were poured into ice coldwater. The solid product was filtered, washed with cold ethanol toremove excess benzofuran-2-carbaldehyde, and dried in a vacuumchamber to collect the green colouredcrude product. The precipitatewas allowed to purify by column chromatography techniqueusing the mixture of Hexane: Ethyl Acetate (2/8): eluent. Rectangularslabsof green colour crystals (yield was 88%) of the TACNBNFwas grown using slow evaporation method by DCM (2 ml) andmethanol (1 ml) mixture solvents.
4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.
Article; Ahamed, J. Irshad; Priya; Vinothkumar; Sathyamoorthy; MuraliManohar; Liu, Jinghe; Valan; Journal of Molecular Structure; vol. 1202; (2020);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem