With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.
Part B Preparation of carbamic acid, 2R-hydroxy-3-[[(2,3-dihydrobenzofuran-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl-, phenylmethyl ester To a solution of 1.11 g (3.0 mmol) of N-[3S-benzyloxy carbonylamino-2R-hydroxy-4-phenyl]-N-isobutylamine in 20 ML of anhydrous methylene chloride, was added 1.3 ML (0.94 g, 9.3 mmol) of triethylamine.. The solution was cooled to 0 C. and 0.66 g of 5-(2,3-dihydrobenzofuranyl) sulfonyl chloride was added, stirred for 15 minutes at 0 C., then for 2 hour at room temperature.. ethyl acetate was added, washed with 5% citric acid, saturated sodium bicarbonate, brine, dried and concentrated to yield 1.62 g of crude material.. This was recrystallized from diethyl ether to afford 1.17 g of pure carbamic acid, [2R-hydroxy-3-[[(2,3-dihydrobenzofuran-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl-, phenylmethyl ester., 115010-11-2
115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; G. D. Searle & Co.; US6388132; (2002); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem