With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102308-43-0,4-Bromo-2-benzofuran-1[3H]-one,as a common compound, the synthetic route is as follows.
To a stirring solution of 3,4-dimethoxy-2-(methoxymethyl)phenylboronic acid(compound 301)(2.3 g, 10.79 mmol) in dimethylformamide (25 mL) under nitrogen atmosphere, were added cesium carbonate (10.52 g, 32.31 mmol),tetrakis(triphenylphosphine)palladium(0) (623 mg, 0.539 mmol) and 4- bromoisobenzofuran-l(3H)-one (5.2 g, 21.5 mmol) and the resultant reaction mixture was heated to 80 C for 3 h. The reaction mixture was filtered off and the filtrate was extracted with ethyl acetate (3 x). The combined ethyl acetate layer was washed with brine and dried over anhydrous sodium sulphate and concentrated under reduced pressure. Purification by column chromatography (silica gel, 0-30% ethyl acetate in pet ether) afforded 4-(3,4-dimethoxy-2-methoxymethoxy-phenyl)-3H-isobenzofuran-l-one as a solid.
102308-43-0 4-Bromo-2-benzofuran-1[3H]-one 11593715, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; LEO PHARMA A/S; NIELSEN, Simon Feldbaek; HORNEMAN, Anne Marie; LAU, Jesper Faergemann; LARSEN, Jens Christian H¡ãjland; WO2011/134468; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem