One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, 3199-61-9, such as the rate of change in the concentration of reactants or products with time.In a article, authors is McClure, Jesse J., mentioned the application of 3199-61-9, Name is Ethyl benzofuran-2-carboxylate, molecular formula is C11H10O3
Development of Allosteric Hydrazide-Containing Class i Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia
One of the biggest hurdles yet to be overcome for the continued improvement of histone deacetylase (HDAC) inhibitors is finding alternative motifs equipotent to the classic and ubiquitously used hydroxamic acid. The N-hydroxyl group of this motif is highly subject to sulfation/glucoronidation-based inactivation in humans; compounds containing this motif require much higher dosing in clinic to achieve therapeutic concentrations. With the goal of developing a second generation of HDAC inhibitors lacking this hydroxamate, we designed a series of potent and selective class I HDAC inhibitors using a hydrazide motif. These inhibitors are impervious to glucuronidation and demonstrate allosteric inhibition. In vitro and ex vivo characterization of our lead analogues’ efficacy, selectivity, and toxicity profiles demonstrate that they possess low nanomolar activity against models of acute myeloid leukemia (AML) and are at least 100-fold more selective for AML than solid immortalized cells such as HEK293 or human peripheral blood mononuclear cells.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 3199-61-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3199-61-9, in my other articles.
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3043O – PubChem