69999-16-2, 2,3-Dihydrobenzofuranyl-5-acetic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(S)-4-Bromo-3-hydrazono-2-oxo-2,3-dihydro- lH-indole-6-carboxylic acid [3-(2- hydroxymethyl-pyrrolidin-l-yl)-propyl]-amide (0.22 g, 0.52 mmol) was added to a solution of (2,3-dihydro-benzofuran-5-yl)-acetic acid (0.93 g, 0.52 mmol), triethylamine (0.01 mL, 0.78 mmol) and HBTU (0.20 g, 0.52 mmol) in DMF (4 mL) and stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and purified by column chromatography (20% methanol in dichloromethane) followed by HPLC (10-100% acetonitrile/water) to give 0.040 g (13%) of (S)-4- bromo-3 – [(2-2,3 -dihy dro-benzof uran-5 -yl-acetyl)-hydrazono] -2-oxo-2,3 -dihydro- 1 H- indole-6-carboxylic acid [3-(2-hydroxymethyl-pyrrolidin-l-yl)-propyl]-amide. 1H NMR (400 MHz, CD3OD) 5 7.75 (s, IH), 7.37 (s, IH), 7.24 (s, IH), 7.11 (d, J = 7.8 Hz, IH), 6.65 (d, / = 8.2 Hz, IH), 4.50 (t, J = 12.7 Hz, 2H), 4.10 (bs, 2H), 3.88 (dd, J = 3.9 Hz, 7= 12.2 Hz, IH), 3.74-3.40 (m, 6H), 3.22-3.04 (m, 4H), 2.26-1.81 (m, 6H). Mass spectrum (LCMS, ESI pos.): Calcd for C27H30BrN5O5: 584.46; found 584.1(M+H). EPO
69999-16-2, The synthetic route of 69999-16-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/101937; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem