The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Category: benzofurans. The article 《Reductions of keto esters with Baker’s yeast in organic solvents – a comparison with the results in water》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:90866-33-4).
The enantiomeric excess in reductions of keto esters with Baker’s yeast (Saccharomyces cerevisiae) can conveniently be altered in organic solvents such as Et2O, PhMe, hexane and EtOAc, when compared to corresponding transformations in water. Thus, while yields were generally lowest in EtOAc, MeCO(CH2)nCO2Et (n = 0, 1) gave nearly quant. yields of (S)-HOCHMe(CH2)nCO2Et in ≤100% e.e. in the other 4 solvents. RCOCH2CO2Et (I; R = ClCH2) gave slightly lower yields of the corresponding (R)-HOCHRCH2CO2Et in all solvents except H2O. The major product isomer and stereoselectivity from I (R= Et, Pr) varied with the solvent.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem