Synthetic Route of 35700-40-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35700-40-4, Name is 2,3-Dihydrobenzofuran-7-carboxylic acid, molecular formula is C9H8O3. In a Article£¬once mentioned of 35700-40-4
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H- tetrazol-5-amine P2X7 antagonists
Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the human and rat P2X7 receptors. On the benzyl moiety, a variety of functional groups were tolerated, including both electron-withdrawing and electron-donating substituents. Ortho-substitution on the benzyl group provided the greatest potency. The ortho-substituted analogs showed approximately 2.5-fold greater potency at human compared to rat P2X 7 receptors. Compounds 12 and 38 displayed hP2X7 pIC 50s >7.8 with less than 2-fold difference in potency at the rP2X7.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35700-40-4, and how the biochemistry of the body works.Synthetic Route of 35700-40-4
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2208O – PubChem