Reference of 652-12-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.652-12-0, Name is Tetrafluorophthalic anhydride, molecular formula is C8F4O3. In a Article£¬once mentioned of 652-12-0
Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure?Degradation Relationships
The immunomodulatory drugs (IMiDs) thalidomide, pomalidomide, and lenalidomide have been approved for the treatment of multiple myeloma for many years. Recently, their use as E3 ligase recruiting elements for small-molecule-induced protein degradation has led to a resurgence in interest in IMiD synthesis and functionalization. Traditional IMiD synthesis follows a stepwise route with multiple purification steps. Herein we describe a novel one-pot synthesis without purification that provides rapid access to a multitude of IMiD analogues. Binding studies with the IMiD target protein cereblon (CRBN) reveals a narrow structure?activity relationship with only a few compounds showing sub-micromolar binding affinity in the range of pomalidomide and lenalidomide. However, anti-proliferative activity as well as Aiolos degradation could be identified for two IMiD analogues. This study provides useful insight into the structure?degradation relationships for molecules of this type as well as a rapid and robust method for IMiD synthesis.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 652-12-0, and how the biochemistry of the body works.Reference of 652-12-0
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3710O – PubChem