Application of 39581-55-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 39581-55-0, 5-Methoxybenzofuran-3(2H)-one, introducing its new discovery.
Benzofuran Bioisosteres of Hallucinogenic Tryptamines
The benzofuran analogues of the hallucinogens 5-methoxy-N,N-dimethyltryptamine and 5-methoxy-alpha-methyltryptamine were synthesized and evaluated for affinity at the serotonin 5-HT2 and 5-HT1A receptors in rat brain homogenate, labeled with <125I>-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (<125I>DOI) and <3H>-8-hydroxy-2-(N,N-di-n-propylamino)tetralin (<3H>-8-OH-DPAT), respectively.At the 5-HT2 receptor, the benzofurans had slightly decreased affinities, approximately one-third and one-sixth those of the indoles, for the primary amines and the tertiary amines, respectively.The benzofurans also had lower affinity at the 5-HT1A receptor, but decreased only about 20-30percent from that of the indole isosteres.Thus, the 5-HT1A receptor is less discriminating with respect to preference for an indole versus a benzofuran, although all of the compounds did have higher affinities for the 5-HT2 receptor than for the 5-HT1A receptor.It is suggested that benzofurans may be useful in the design of serotonin receptor ligands.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 39581-55-0. In my other articles, you can also check out more blogs about 39581-55-0
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2245O – PubChem