496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(1) 4-(2,3-dihydro-1-benzofuran-5-yl)-4-oxobutanoic acid To a suspension of 2,3-dihydro-1-benzofuran (5.2 g) and succinic anhydride (5.2 g) in dichloromethane (30 mL) was gradually added aluminum chloride (14.4 g) under ice-cooling, and the mixture was heated with stirring at 50¡ãC for 0.5 hr. The reaction mixture was cooled, and poured into concentrated hydrochloric acid (100 mL)-ice. The mixture was stirred for 1 hr, and extracted with ethyl acetate. The obtained organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, and the obtained residue was recrystallized from ethyl acetate to give 4-(2,3-dihydro-1-benzofuran-5-yl)-4-oxobutanoic acid as crystals (3.8 g). 1H-NMR (CDCl3) delta: 2.80 (2H, t, J=6.0 Hz), 3.26(4H, m), 4.67(2H, t, J=9.0 Hz), 6. 82 (1H, d, J=8.4 Hz), 7.85(2H, m)
496-16-2, 496-16-2 2,3-Dihydrobenzo[b]furan 10329, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1845081; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem