Downstream synthetic route of 23681-89-2

As the paragraph descriping shows that 23681-89-2 is playing an increasingly important role.

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a cooled (0 ¡ãC) solution of 2,3-dihydrobenzofuran-6-ol (0.52 g, 3.8 mmol) in anhydrous tetrahydrofuran (25 ml.) was added isopropylmagnesium chloride (2.1 ml_, 2 M solution in tetrahydrofuran, 4.2 mmol). The resultant suspension was stirred at 0 ¡ãC for 0.5 h and followed by the addition of 7-chloro-1-(diphenylmethyl)-1H-indole-2,3- dione (2.11 g, 15.5 mmol) in one portion. The reaction mixture was stirred at ambient temperature for 3 h and concentrated in vacuo. The crude product was purified by column chromatography with ethyl acetate in hexanes (0percent to 50percent gradient) to afford 7-chloro-1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)- 1 ,3-dihydro-2H-indol-2-one (7.12 g, 95percent) as a colorless solid: 1H NMR (300 MHz, DMSO-CZ6) .pound.9.43 (s, 1 H), 7.56-7.18 (m, 13H), 6.99-6.86 (m, 2H), 6.60 (s, 1 H), 6.08 (s, 1H), 4.56 (t, J = 8.6 Hz, 2H), 3.10 (t, J = 8.6 Hz, 2H). C. Synthesis of 7-chloro-1 -(diphenylmethyl)-3-(6-hvdroxy-2,3-dihydro-1 – benzofuran-5-yl)-1,3-dihydro-2/-/-indol-2-one, 23681-89-2

As the paragraph descriping shows that 23681-89-2 is playing an increasingly important role.

Reference£º
Patent; XENON PHARMACEUTICALS, INC.; CHAFEEV, Mikhail; CHOWDHURY, Sultan; FRASER, Lauren; FU, Jianmin; LANGILLE, Jonathan; LIU, Shifeng; SUN, Jianyu; SUN, Shaoyi; SVIRIDOV, Serguei; WOOD, Mark; ZENOVA, Alla; JIA, Qi; CADIEUX, Jean-Jacques; GAUTHIER, Simon, J.; DOUGLAS, Amy Frances; HSIEH, Tom; CHAKKA, Nagasree; CIKOJEVIC, Zoran; WO2010/45251; (2010); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem