Chaita, Eliza’s team published research in Phytochemical Analysis in 28 | CAS: 56317-21-6

Phytochemical Analysis published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Chaita, Eliza published the artcileIntegrated HPTLC-based Methodology for the Tracing of Bioactive Compounds in Herbal Extracts Employing Multivariate Chemometrics. A Case Study on Morus alba, Category: benzofurans, the publication is Phytochemical Analysis (2017), 28(2), 125-131, database is CAplus and MEDLINE.

Introduction : In drug discovery, bioassay-guided isolation is a well-established procedure, and still the basic approach for the discovery of natural products with desired biol. properties. However, in these procedures, the most laborious and time-consuming step is the isolation of the bioactive constituents. A prior identification of the compounds that contribute to the demonstrated activity of the fractions would enable the selection of proper chromatog. techniques and lead to targeted isolation. Objective : The development of an integrated HPTLC-based methodol. for the rapid tracing of the bioactive compounds during bioassay-guided processes, using multivariate statistics. Materials and Methods – The methanol extract of Morus alba was fractionated employing CPC. Subsequently, fractions were assayed for tyrosinase inhibition and analyzed with HPTLC. PLS-R algorithm was performed in order to correlate the anal. data with the biol. response of the fractions and identify the compounds with the highest contribution. Two methodologies were develop generation. Results and Discussion – Both methodologies afforded comparable results and were able to trace the bioactive constituents. The suggested compounds were compared terms of Rf values and UV spectra with compounds isolated from M. alba using typical bioassay-guided process. Conclusion : Chemometric tools supported the development of a novel HPTLC-based methodol. for the tracing of tyrosinase inhibitors in M. alba extract

Phytochemical Analysis published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem