Category: benzofurans

Chemistry, like all the natural sciences, Application In Synthesis of 5-Methylfuran-2(5H)-one, begins with the direct observation of nature— in this case, of matter.591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a document, author is Yamagiwa, Yoshiro, introduce the new discover.

Improved and Practical Synthesis of the Integrastatin Core

The new and versatile method for the synthesis of integrastatin core has been developed by the use of o-toluic acid and 2′-hydroxyacetophenone with NaH/sec-BuLi, followed by the reaction of dihydroisocoumarins with MeLi. The overall steps for the synthesis of integrastatin core was only 3 steps including the known method by the literature. The scope and limitations of substrates bearing the various substituents on the aromatic ring were investigated. The chemical yields by our approach are generally high and the current route enables us the rapid synthesis.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 591-11-7. Application In Synthesis of 5-Methylfuran-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, belongs to benzofurans compound. In a document, author is Shyni, Gangadharan Leela, introduce the new discover.

An in vitro study reveals the anti-obesity effects of 7-methoxy-3-methyl-5((E)-prop-1-enyl)-2-(3,4,5-trimethoxyphenyl)-2,3-dihydrobenzofuran from Myristica fragrans

Adipogenesis, the maturation process of preadipocytes, is closely associated with the development of obesity and other complex metabolic syndromes. Herein, we investigated the effect of 7- methoxy-3-methyl-5-((E)- prop-1-enyl)-2-(3,4,5-trimethoxyphenyl)-2,3-dihydrobenzofuran (TM), a benzofuran, isolated from the mace of Myristica fragrans Houtt on adipogenesis in 3T3-L1 preadipocytes to extrapolate whether this compound has any antiobesity potential. For this, 3T3-L1 preadipocytes were induced to differentiate in the presence of various concentrations of TM (1, 5, 10 mu M) and analyzed for triglyceride (TG) accumulation and the expression of proteins and genes involved in lipogenesis and lipolysis associated with adipogenesis. Results showed that TM significantly reduced TG accumulation and expression of marker proteins of adipocyte differentiation (pemxisome proliferator-activated receptor y, CCAAT/enhancer-binding protein a, and fatty acid-binding protein 4) and increased the secretion of glycerol in a dose-dependent manner. There was a significant dose-dependent decrease in the expression of fatty acid synthase, steamyl-CoA desaturase-1, sterol regulatory element-binding transcription factor 1c, and acetyl-CoA carboxylase 1 and an increase in carnitine palmitoyltransferase 1, acyl-CoA oxidase, and peroxisome proliferator-activated receptor a in TM treated cells. The phosphorylation of cAMP-activated protein kinase was also increased, which in turn activated the phosphorylation of acetyl-CoA carboxylase in mature adipocytes. Also, there was an increase in glucose uptake by TM, suggesting its insulinsensitizing potential. This is the first report on the anti-obesity effects of TM from Myristica fragrans on adipogenesis and lipid metabolism in 3T3-L1 adipocytes and demands detailed in vivo study for developing TM as antiobesity therapeutics.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 97148-39-5. Application In Synthesis of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 87-41-2, Name is Isobenzofuran-1(3H)-one, formurla is C8H6O2. In a document, author is Dias, Natalia C., introducing its new discovery. HPLC of Formula: C8H6O2.

Ozonation of the dye Reactive Red 239 and biodegradation of ozonation products in a moving-bed biofilm reactor: Revealing reaction products and degradation pathways

The ozonation of the azo dye Reactive Red 239 (RR 239) was investigated in a bench-scale reactor. Decolorization and organic matter removal were monitored in batch assays. The toxicity of the dye and its ozonation products to the test-organism Aliivibrio fischeri was also assessed. Identification of ozonation products was performed using analytical techniques (GC-MSD and high resolution mass spectrometry). Ozonated and non-ozonated dye solutions were supplemented with organic matter (glucose) and nutrients sources and subjected to biological treatment in a moving-bed biofilm reactor (MBBR). Five experimental runs were conducted, varying the influent characteristics and monitoring organic matter removal and nitrification performance. Identification of residual compounds in the effluent was also performed. Color was very rapidly removed by ozonation, but the degree of mineralization achieved was rather low. Moreover, toxicity was completely removed after 4 min of ozone reaction. Based on the ozonation products, a two-way mechanism was proposed for the degradation of RR 239 by ozone. Further biological treatment in the MBBR revealed that the removal of organic matter (evaluated as COD) was not affected by the ozonation products. However, nitrification efficiency dropped significantly when the dye or the ozonated dye was fed to the bioreactor. Furthermore, inhibition of nitrite oxidizers resulted in partial nitrification and consequent accumulation of nitrite, which consisted of the main oxidized nitrogen specie in the reactor effluent. The identification of compounds resulting from the ozonation and biological treatment steps suggests that the partial inhibition of nitrifying organisms was possibly caused by triazine- and benzofuran-related organic compounds. Nevertheless, their adverse effect on nitrification was found to be reversible and practically ceased once these compounds were removed from the influent. Overall, the results revealed that the combination of ozonation and MBBR for the treatment of azo dye containing-wastewaters is promising but the ozone-based process should be optimized in order to enable the degradation of compounds inhibiting nitrification.

If you are hungry for even more, make sure to check my other article about 87-41-2, HPLC of Formula: C8H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is Kumar, Gourav, once mentioned the new application about 4412-91-3, Formula: C5H6O2.

Synthesis and Biological Evaluation of Quinoline-Based Novel Aurones

A new series of quinoline based aurones 7(a-n) has been synthesized and evaluated for their antibacterial, antifungal and antiquorum sensing activities. These novel aurones have been prepared directly from 2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one in one pot, by reacting it with differently substituted 2-chloroquinoline-3-carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures of these novel aurones are in agreement with their IR, H-1-NMR, C-13-NMR and HRMS data. Some of these compounds have attributed a significant antiquorum sensing activity.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4412-91-3. The above is the message from the blog manager. Formula: C5H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, in an article , author is Zhao, Chao, once mentioned of 174775-48-5, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibiting DYRK1A. Eight isopentenyl-substituted compounds (1-8), including four coumarins (1-4), one benzofuran (5), and three flavonoids (6-8), were isolated and identified from G. uralensis Fisch. Among them, licocoumarone (LC, 5) showed effective inhibitory activity against DYRK1A with an IC50 value of 12.56 mu M. Molecular docking analysis suggested that LC completely occupied the whole pocket of DYRK1A and formed obvious hydrophobic interactions and hydrogen bonds with DYRK1A residues. Further in vitro validation, including Microscale Thermophoresis (MST) and drug affinity responsive target stability (DARTS) techniques, demonstrated the specific combining capacity of LC to DYRK1A. Meanwhile, LC induced significant cytotoxicity against DYRK1A-overexpressing BxPC-3 cells with an IC50 value of 50.77 mu M. Mechanism studies revealed that LC reduced c-MET protein level by inhibiting DYRK1A. These findings provide preliminary evidences that LC as a natural DYRK1A inhibitor suppresses human pancreatic adenocarcinoma BxPC-3 cell proliferation and induces cell apoptotic, which might present new options and possibilities for targeted therapies in pancreatic cancer therapy.

Interested yet? Read on for other articles about 174775-48-5, you can contact me at any time and look forward to more communication. Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Maridevarmath, C., V, once mentioned the application of 14400-67-0, COA of Formula: C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

Synthesis, characterization and photophysical studies on novel benzofuran-3-acetic acid hydrazide derivatives by solvatochromic and computational methods

In the present studies, synthesis of two novel benzofuran-3-acetic acid hydrazide derivatives namely, (6-methyl-benzofuran-3-yl)-acetic acid hydrazide [6MLBH] and (6-methoxy-benzofuran-3-yl)-acetic acid hydrazide [6MOBH] are reported. The probes are characterized by IR, H-1-NMR, C-13-NMR and mass spectral methods. The absorption and fluorescence maxima of novel derivatives 6MLBH and 6MOBH are determined for different solvents of varying polarity and the solvatochromic behavior and dipole moments are investigated. Stoke’s shift exhibits a red shift with increase in solvent polarity for both the probe molecules indicating a pi ->pi* transition. The ground state dipole moment (mu g) of both the molecules in gaseous phase is estimated from ab initio computations by using Gaussian 09 W software and also from solvatochromic method and the results are compared. Further, the ground state dipole moments of the probe molecules in different solvents were also estimated theoretically by using the integral equation formalism of polarizable continuum model (IEF-PCM). By using solvatochromic correlations like Lippert’s, Bakhshiev’s, Kawski-Chamma-Viallet’s and solvent polarity parameter (E-T(N)), the excited state dipole moments (mu(e)) are determined. Results show that, the excited state dipole moments (mu(e)) are higher than the ground state dipole moments (mu g) and suggest that, the probe molecules 6MLBH and 6MOBH are more polar in the excited state. The HOMO-LUMO energy gaps computed from density functional theory (DFT) and from absorption threshold wavelengths are found to be in agreement and also support intramolecular charge transfer (ICT). Using HOMO-LUMO energies, the chemical hardness (eta) of the molecules are determined and the chemical stability is discussed. Further, using DFT molecular electrostatic potential (MESP) plots, the electrophilic site and nucleophilic site which are useful in photochemical reactions were identified. The various types of interactions present between the solute-solvent were analyzed by multiple linear regression analysis using Catalan parameters. The preliminary observations and results suggest that, the probe molecules 6MLBH and 6MOBH can be considered as potential candidates for luminescence materials, fluorescent probes and for designing non-linear optical materials in future. (C) 2019 Elsevier B.V. All rights reserved.

If you are interested in 14400-67-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2. In an article, author is Song, Zhi-Qiang,once mentioned of 4412-91-3, Formula: C5H6O2.

Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid

Boric acid, B(OH)(3), is proved to be an efficient hydroxide reagent in converting (hetero)aryl halides to the corresponding phenols with a Pd catalyst under mild conditions. Various phenol products were obtained in good to excellent yields. This transformation tolerates a broad range of functional groups and molecules, including base-sensitive substituents and complicated pharmaceutical (hetero)aryl halide molecules.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4412-91-3, you can contact me at any time and look forward to more communication. Formula: C5H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 497-23-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Abdelfatah, Sara, introduce new discover of the category.

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1 PBD was confirmed using fluorescence polarization and microscale thermophoresis. This compound exerted specificity towards PLK1 over PLK2 and PLK3. MCC1019 showed cytotoxic activity in a panel of different cancer cell lines. Mechanistic investigations in A549 lung adenocarcinoma cells revealed that MCC1019 induced cell growth inhibition through inactivation of AKT signaling pathway, it also induced prolonged mitotic arrest-a phenomenon known as mitotic catastrophe, which is followed by immediate cell death via apoptosis and necroptosis. MCC1019 significantly inhibited tumor growth in vivo in a murine lung cancer model without affecting body weight or vital organ size, and reduced the growth of metastatic lesions in the lung. We propose MCC1019 as promising anti-cancer drug candidate. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Reference of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, in an article , author is Abdel-Aziem, Anhar, once mentioned of 497-23-4, COA of Formula: C4H4O2.

Eco-Friendly Synthesis of 3-Aryl-2,3-dihydro-1,3,4-thiadiazoles Based on Benzofuran and Chromone Moieties

In consideration of green and efficient organic chemical methodology, we reported here a green, an efficient and convenient procedure for synthesis of 3-aryl-2,3-dihydro-1,3,4-thiadiazoles based on benzofuran as well as chromone moieties, using the grinding technique. Condensation of 1-(4,7-dimethoxybenzofuran-5-yl)ethan-1-ones 2, 3; 7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde (4); and 4-oxo-4H-chromene-3-carbaldehydes 10a-c with alkyl hydrazine carbodithioates followed with some hydrazonoyl halides 7a-g under grinding and solvent-free condition led to the formation of the targeted 3-aryl-2,3-dihydro-1,3,4-thiadiazoles 8a-g, 9a,b, and 12a-f, correspondingly. Structures of the synthesized compounds were clarified based on their elemental analyses and spectral data. Eleven of the entire target compounds were selected for anticancer activity against 60 human cancer cell lines at a single dose (10?(5) M) by the National Cancer Institute (NCI, Bethesda, USA).

Interested yet? Read on for other articles about 497-23-4, you can contact me at any time and look forward to more communication. COA of Formula: C4H4O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Formula: C8H6O2, 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, in an article , author is Wang, Xunchang, once mentioned of 87-41-2.

Terpolymer Strategy toward High-Efficiency Polymer Solar Cells: Integrating Symmetric Benzodithiophene and Asymmetrical Thieno[2,3-f]benzofuran Segments

While a large number of terpolymers have been developed for polymer solar cells, very few studies have directly focused on the rational selection of the third component to balance the miscibility and crystallinity for forming the desired morphology, and universal terpolymer strategies for preparing different donor/acceptor systems are lacking. Herein, we employ a new strategy involving the integration of benzodithiophene (BDT) and thieno [2,3-f ]benzofuran (TBF) segments to construct a series of terpolymer donors, and a profound influence on the crystallinity and miscibility of the blend films as well as on the ultimate device performance is observed. Incorporating highly crystalline TBF segments into a low-crystalline BDT-based alternating copolymer can not only increase the order of the microstructure, conserve the favorable face-on orientation, and promote the formation of proper phase-separation features but also generate high exciton dissociation and suppress charge recombination. This strategy was successfully applied in the reported J52 system and provided a remarkable 2-fold boost in performance. Finally, competitive power conversion efficiencies of 11.9, 12.4, and 12.2% accompanied by high fill factors of 73, 71, and 76% were recorded for TBFC150-FTAZ/ITIC-, TBFC150-BDD/ITIC-, and TBFC150-BDD/IDIC-C4Ph-based devices, respectively, via the above terpolymer strategy. Thus, our discovery provides a promising and innovative method for finely controlling the microstructure of heterojunctions for designing high-performance terpolymers.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 87-41-2, you can contact me at any time and look forward to more communication. Formula: C8H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem