Chemistry, like all the natural sciences, Application In Synthesis of 5-Methylfuran-2(5H)-one, begins with the direct observation of nature— in this case, of matter.591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a document, author is Yamagiwa, Yoshiro, introduce the new discover.
Improved and Practical Synthesis of the Integrastatin Core
The new and versatile method for the synthesis of integrastatin core has been developed by the use of o-toluic acid and 2′-hydroxyacetophenone with NaH/sec-BuLi, followed by the reaction of dihydroisocoumarins with MeLi. The overall steps for the synthesis of integrastatin core was only 3 steps including the known method by the literature. The scope and limitations of substrates bearing the various substituents on the aromatic ring were investigated. The chemical yields by our approach are generally high and the current route enables us the rapid synthesis.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 591-11-7. Application In Synthesis of 5-Methylfuran-2(5H)-one.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem