Category: benzofurans

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 54008-77-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 54008-77-4, Name is 2-Bromobenzofuran, molecular formula is C8H5BrO

A palladium catalyst based on a bidentate phosphine-type zwitterionic surfactant as a ligand exhibited an excellent catalytic activity in the Suzuki-Miyaura cross coupling reactions. This novel method allowed the reaction of aryl halides with arylboronic acids to occur in pure water at room temperature, forming a variety of biaryls in good to high yields. Heterobiaryls were also efficiently assembled even in the presence of water-insoluble heteroaryl halides as substrates. In addition, such a coupling protocol was successfully used in the iterative diarylation of 2,5-dibromopyridine in one-pot.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3256O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4265-25-2, name is 2-Methylbenzofuran, introducing its new discovery. name: 2-Methylbenzofuran

The expected 7-alkoxy-2-methylbenzo[b]furans were effectively given in the CsF-mediated Claisen rearrangement of phenyl propargyl ethers with an o-alkoxy substituent on the benzene ring. On the other hand CsF did not affect the production of the corresponding benzo[b]furans when ethers, carrying a propargyl residue modified by either 1,1-dimethyl or 3-ethoxycarbonyl functions, were used as substrates in the rearrangement.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H150O – PubChem

Electric Literature of 69604-00-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.69604-00-8, Name is Ethyl 5-nitrobenzofuran-2-carboxylate, molecular formula is C11H9NO5. In a Article，once mentioned of 69604-00-8

Targeted radionuclide therapy using radioiodinated compounds with a specific affinity for melanoma tissue is a promising treatment for disseminated melanoma, but the candidate with the ideal kinetic profile remains to be discovered. Targeted radionuclide therapy concentrates the effects on tumor cells, thereby increasing the efficacy and decreasing the morbidity of radiotherapy. In this context, analogues of N-(2-diethylaminoethyl)-4- iodobenzamide (BZA) are of interest. Various (hetero)aromatic analogues 5 of BZA were synthesized and radioiodinated with 125I, and their biodistribution in melanoma-bearing mice was studied after i.v. administration. Most [125I]5-labeled compounds appeared to bind specifically and with moderate-to-high affinity to melanoma tumor. Two compounds, 5h and 5k, stood out with high specific and long-lasting uptake in the tumor, with a 7- and 16-fold higher value than BZA at 72 h, respectively, and kinetic profiles that makes them promising agents for internal targeted radionuclide therapy of melanoma.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 69604-00-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3866O – PubChem

Application of 24673-56-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, molecular formula is C10H8O3. In a Article，once mentioned of 24673-56-1

(Chemical Equation Presented) Flash vacuum pyrolyses (FVP) of benzoic 3-methyl-2-benzofurancarboxylic anhydride (12) and benzoic 2-methyl-3- benzofurancarboxylic anhydride (13) at 550C and ca. 10-2 torr both give methylenebenzocyclobutenone (21) as the major product and indenone (22) as the minor one. A mechanism involving generation of alpha-oxo-o- quinodimethane 11 as the primary pyrolysis product from FVP of 13, followed by elimination of a CO molecule to give carbene 24, which undergoes a vinylcarbene-cyclopropene rearrangement and a ring contraction of the resulting carbene 23, is proposed to account for the observed results. The proposed mechanism is further supported by a deuterium-labeling study on FVP of (2-benzofuryl)methyl-alpha,alpha-d2 benzoate (28-d2).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 24673-56-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2781O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C9H6O3. Introducing a new discovery about 496-41-3, Name is Benzofuran-2-carboxylic acid

Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values. The biological results for these compounds indicate on average a lower clogP limit of about 5.0 in this series for retention of potent inhibitory activity (MIC90s) against M.tb in culture. Some of the compounds also showed a significant reduction in inhibition of hERG channel potassium current compared with bedaquiline, but there was no common structural feature that distinguished these.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1979O – PubChem

Electric Literature of 24673-56-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid,introducing its new discovery.

Benzofuran compound, composition thereof, kit thereof, and/or method thereof. A benzofuran-2-carboxamide moiety may be N-arylated and/or N-alkylated, and the resulting benzofuran compound may be a sigma receptor ligand that binds to, e.g., a sigma1 receptor and/or a sigma2 receptor with relatively high affinity and/or selectivity. For example, the benzofuran compound may be 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, 3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, or 6-methoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide. The composition may include the benzofuran compound and a pharmaceutically acceptable carrier.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2697O – PubChem

Electric Literature of 652-12-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.652-12-0, Name is Tetrafluorophthalic anhydride, molecular formula is C8F4O3. In a Article，once mentioned of 652-12-0

A formal [5 – 1 + 2] annulation for the preparation of substituted alpha-pyrones is reported. The reaction involves the decarbonylative coupling of substituted maleic anhydrides with internal alkynes in the presence of a rhodium(III) catalyst and a copper(II) salt, affording tri- and tetrasubstituted alpha-pyrones. the Partner Organisations 2014.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3738O – PubChem

Synthetic Route of 42933-43-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 42933-43-7, 2,3-Dihydrobenzofuran-5-amine, introducing its new discovery.

We report a series of tubulin targeting agents, some of which demonstrate potent antiproliferative activities. These analogs were designed to optimize the antiproliferative activity of 1 by varying the heteroatom substituent at the 4?-position, the basicity of the 4-position amino moiety, and conformational restriction. The potential metabolites of the active compounds were also synthesized. Some compounds demonstrated single digit nanomolar IC50 values for antiproliferative effects in MDA-MB-435 melanoma cells. Particularly, the S-methyl analog 3 was more potent than 1 in MDA-MB-435 cells (IC50 = 4.6 nM). Incubation of 3 with human liver microsomes showed that the primary metabolite of the S-methyl moiety of 3 was the methyl sulfinyl group, as in analog 5. This metabolite was equipotent with the lead compound 1 in MDA-MB-435 cells (IC50 = 7.9 nM). Molecular modeling and electrostatic surface area were determined to explain the activities of the analogs. Most of the potent compounds overcome multiple mechanisms of drug resistance and compound 3 emerged as the lead compound for further SAR and preclinical development.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 42933-43-7. In my other articles, you can also check out more blogs about 42933-43-7

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H514O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 4790-81-2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 4790-81-2

Contamination of water by organic pollutants is a common environmental problem. Over a period of 1 year, the surface water of a canal network (Languedoc-Roussillon area, France) was analysed in order to identify organic compounds and to monitor its quality. Pollutants were extracted from 19 1 of raw water using methylene chloride in a continuous countercurrent liquid-liquid extractor with a pulsed column. The extraction was performed at a pH above 11 and again at a pH below 2 according to U.S. Environmental Protection Agency method 625. The extract was analysed by gas chromatography/mass spectrometry, using two ionization techniques, namely electron ionization and chemical ionization. Mass spectra obtained by electron ionization were compared with those in a database (NIST). Some natural compounds and micropollutants were identified. Their structures were confirmed by chemical ionization (methane). One hundred and ten substances, making up the broad spectrum of extractable compounds in the surface water studied, were found by this method at a nanogram per litre concentration level. Among them, 13 are priority pollutants. These specific pollutants were qualified.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H447O – PubChem

4741-62-2, Name is 5-Methoxyisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. Computed Properties of C9H8O3In an article, once mentioned the new application about 4741-62-2.

Benzylic ethers undergo a visible light induced C-H activation and oxygen insertion to give the corresponding benzoate esters in moderate to good yields. The conditions employ substoichiometric amounts of 1,4-hydroquinone with copper(ii) chloride dihydrate as an electron-transfer mediator, oxygen as the terminal oxidant and dimethyl carbonate as solvent under visible light irradiation. The naturally occurring glucoside, arbutin, which is commercially available or can be accessed via extraction of the leaves of bearberry (Arctostaphylos uva-ursi) or elephant ears (Bergenia crassifolia) can be used as a biorenewable source of 1,4-hydroquinone. The methodology exploits the increase in oxidizing ability of quinones upon irradiation with visible light, and offers a sustainable alternative for the late stage oxidative functionalization of benzylic C-H bonds. It is applicable to a range of cyclic benzylic ethers such as isochromans and phthalans, and simple benzyl alkyl ethers. It can also be applied in the oxidation of benzylic amines into amides, and of diarylmethanes into the corresponding ketones. Mechanistic studies suggest that the reaction proceeds by H-abstraction by the photo-excited triplet benzoquinone to give a benzylic radical that subsequently reacts with molecular oxygen.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2258O – PubChem