Category: benzofurans

4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, belongs to benzofurans compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 4265-16-1.

Inspired by the dicationic nature of the electrophilic fluorinating reagent, Selectfluor (1), we rationally designed a series of dicarboxylic acid precatalysts (2), which, when deprotonated, act as anionic phase-transfer catalysts for asymmetric fluorination of alkenes. Among them, 2a having the shortest linker moiety efficiently catalyzed unprecedented 6-endo-fluoro-cyclization of various allylic amides, affording fluorinated dihydrooxazine compounds with high enantioselectivity (up to 99% ee). In addition to cyclic substrates, acyclic trisubstituted alkenes underwent the reaction with good diastereoselectivity, whereas low diastereoselectivity was observed for linear disubstituted alkenes. Results suggest that the reaction proceeds via a fluoro-carbocation intermediate.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H807O – PubChem

Reference of 54109-03-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.54109-03-4, Name is 5-Chloroisobenzofuran-1(3H)-one, molecular formula is C8H5ClO2. In a Article，once mentioned of 54109-03-4

Getting a handle on it: In the chelation-assisted title reactions in the presence of a hypervalent iodine oxidant, sodium azide and sodium nitrite served as readily available nitrogen sources, and pyridine, pyrimidine, and pyrazole substituents were efficient directing groups (DGs; see scheme; Cp=C 5Me5). The synthetic utility of the azidation products was demonstrated in subsequent functional-group transformations. Copyright

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2643O – PubChem

Synthetic Route of 652-39-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 652-39-1, molcular formula is C8H3FO3, introducing its new discovery.

This paper describes the synthesis of N-pyridinyl(alkyl)phthalimides related to N-phenyl-4,5,6,7-tetrafluorophthalimides known to be inhibitors of tumour necrosis factor-alpha (TNFalpha) production. Pharmacomodulation at the phthalimidic nitrogen led to the selection of two pharmacophoric fragments (2,4-lutidinyl and beta-picolyl), allowing significant inhibition of TNFalpha production (compounds 12 and 17). Variation of the substituents linked to the homocycle of their phthalimide scaffold indicated that high (TNFalpha production) inhibitory potency could be achieved, notably by 5-fluoro, 4- or 5-nitro, 5-amino and especially tetrafluoro substitution. The most active compound, N-(pyridin-3-ylmethyl)-4,5,6,7-tetrafluorophthalimide (32) (84% inhibition at 10 muM), also produced an anti-oedematous effect in the PMA-induced mouse-ear swelling test. Although less active than dexamethasone, it exerted a marked reduction in ear thickness after oral administration (63% vs. 85% for dexamethasone at 0.2 mM kg-1) and remained efficient after topical application (46% vs. 96% for the dexamethasone). It also induced potent inhibition in the rat carrageenan foot oedema test with an ID50 (0.14 muM kg-1) comparable with that of N-(2,6-diisopropylphenyl)phthalimide (4) (0.15 muM kg-1).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 652-39-1 is helpful to your research. Synthetic Route of 652-39-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2519O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 496-41-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ?90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1989O – PubChem

Reference of 50551-63-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2. In a article，once mentioned of 50551-63-8

2-(5-Resorcinyl)benzofurans have been synthesised by the palladium catalysed cross coupling of 2-trimethylstannyl- or 2-bromozinc benzofurans with the appropriately functionalised 5-iodoresorcinols.These were synthesised by the tri-isopropylsilyloxy directed remote (C-5) lithiation/iodination of the O,O-di(triisopropylsilyl)resorcinoltricarbonylchromium(0) complex.The method was applied to the synthesis of moracin M, a phytoalexin of Morus alba Linn.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1323O – PubChem

Synthetic Route of 13099-95-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 13099-95-1, Name is Ethyl 3-oxo-2,3-dihydrobenzofuran-2-carboxylate,introducing its new discovery.

In the present study we have made an attempt to synthesize novel benzofuran derivatives and evaluate them for anticancer screening. First, 2-carbethoxy-3 (2H) benzofuranone (2) was prepared by the condensation of ethyl bromomalonate with methyl salicylate (1) in presence of anhydrous potassium carbonate. Treatment of 2- carbethoxy-3 (2H) benzofuranone (2) with dimethylsulphate in presence of anhydrous potassium carbonate afforded 2-carbethoxy-3-methoxy benzofuranone (3). 2- Carbethoxy-3-methoxy benzofuranone (3) on treatment with hydrazine hydrate gave 3-methoxybenzofuran-2-carbohydrazide (4) and then condensation of 3- methoxybenzofuran-2-carbohydrazide (4) with various substituted benzaldehydes led to a novel series of benzofuran derivatives (5a-k). The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their short-term anticancer activity. The synthesized benzofuran derivative possessed significant cytotoxic activity against Ehrlich’s Ascites Carcinoma (EAC) cell lines and HEP2 cell line by Sulforhodamine B assay.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3503O – PubChem

Application of 4265-16-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4265-16-1, Benzo[b]furan-2-carboxaldehyde, introducing its new discovery.

A simple synthesis method of nitriles from corresponding aldehydes by electrochemical oxidation was developed with ammonium acetate as the nitrogen source and 4-acetamido- 2,2,6,6-tetramethylpiperidinyl-l-oxy (4-AcNH-TEMPO) as the catalyst. Cyclic voltammetry was performed to investigate the electrocatalytic activity of 4-AcNH-TEMPO for the conversion of benzaldehyde to benzonitrile. On the basis of in situ FTIR data and cyclic voltammetry experiments, a reaction mechanism, involving the redox of 4-AcNH-TEMPO and the generation of intermediate imine during the reaction, was proposed. This electrocatalytic reaction system provided an efficient protocol for synthesis of aromatic nitriles at room temperature with moderate to high yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 4265-16-1. In my other articles, you can also check out more blogs about 4265-16-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1121O – PubChem

Synthetic Route of 652-12-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 652-12-0, Tetrafluorophthalic anhydride, introducing its new discovery.

Subtype-selective alpha-1a and/or alpha-1d adrenergic receptor antagonists may be useful for the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) with fewer adverse effects than non-selective drugs. A series of 1-arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones has been synthesized, displaying in vitro alpha1a and alpha1d binding affinity Ki values in the range of 0.09-38 nM with Ki(alpha1b)/Ki(alpha1a) and Ki(alpha1b)/Ki(alpha1d) selectivity ratios up to 3607-fold.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3733O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of Ethyl benzofuran-2-carboxylate. Introducing a new discovery about 3199-61-9, Name is Ethyl benzofuran-2-carboxylate

The logarithm of capacity factors (log k’) previously measured from the reversed-phase high-performance liquid chromatography (RP-HPLC) and the octanol-water partition coefficients (log P) of a mixed set of substituted benzene, furan, benzofuran, pyrrole, 1-Me-pyrrole, indole, and N-methyl indole derivatives are correlated with the descriptors obtained from their three-dimensional structures for a mixed set of compounds.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3033O – PubChem

Application of 652-39-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione, molecular formula is C8H3FO3. In a Patent，once mentioned of 652-39-1

Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in parasitic heme auxotrophic organisms, thereby limiting their growth or killing the parasites.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2483O – PubChem