With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.
A mixture of 44.4 g (0.37 moles) of 2,3-dihydrobenzofuran and 37.8 g (0.37 moles) of acetic anhydride were added with 5.0 g (37 mmoles) of anhydrous zinc chloride. The mixture was heated to 95-105 0C for 10 hrs; after cooling to room temperature the mixture is added with 50 ml of water and 50 ml of dichloromethane. The organic phase was separated and the aqueous phase was extracted twice with dichloromethane (2x 30 ml). The organic phases were collected together, and washed with 50 ml of a saturated aqueous solution of sodium carbonate. The organic phase was separated and evaporated u.v. (20 ¡ãC/21 mbar). The residue was then distilled at 99-100 ¡ãC/0.08 mbar obtaining 14.5 g (0.089 moles) of 5-acetyl-2,3- dihydrobenzofuran. 1H NMR (400 MHz; CDCI3): delta: 2.50 (s, 3H); 3.20 (t, 2H, J = 8.7 Hz); 4.64 (t, 2H, J = 8.7 Hz); 6.76 (d, 1 H, J = 8.4 Hz); 7.76 (m, 1 H); 7.81 (m, 1 H).13C-NMR (CDCI3, 100MHz): delta: 26.22; 28.79; 72.02; 108.72; 125.34; 127.50; 130.17; 130.48; 164.19; 196.41.
As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.
Patent; ENDURA S.P.A.; ROTHAMSTED RESEARCH LTD.; BORZATTA, Valerio; CAPPARELLA, Elisa; MORONI, Leni; MOORES, Graham; PHILIPPOU, Despina; WO2011/20848; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem