Category: benzofurans

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H7BrO. Introducing a new discovery about 189035-22-1, Name is 6-Bromo-2,3-dihydrobenzofuran

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer’s disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C8H7BrO, you can also check out more blogs about189035-22-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3394O – PubChem

Reference of 18959-30-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 18959-30-3, 4,5-Difluorophthalic Anhydride, introducing its new discovery.

PROBLEM TO BE SOLVED: To provide a polyfunctional amide acid compound which, when used as a crosslinking agent of a resin composition, achieves crosslinking at high density and an improvement in the elastic modulus of a resin molding, and a polyfunctional imide compound as a derivative thereof. SOLUTION: This invention provides a novel polyfunctional amide acid compound obtained by a reaction between triamine or tetraamine and dicarboxylic anhydride, and a polyfunctional imide compound as a derivative thereof. COPYRIGHT: (C)2015,JPO&INPIT

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 18959-30-3. In my other articles, you can also check out more blogs about 18959-30-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2917O – PubChem

16859-59-9, Name is 3-Hydroxyisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. Application In Synthesis of 3-Hydroxyisobenzofuran-1(3H)-oneIn an article, once mentioned the new application about 16859-59-9.

A reaction involving 1-hydrazinophthalazine (hydralazine, 1) designed to give a condensed heterocyclic system in which an eight membered ring is fused to phthalazine was investigated.With phthalaldehydic acid (2) the expected system was obtained.However, it occurs as an easily convertible mixture of ring-chain tautomers.It was found that the course of the reaction depends on the solvent.Thus, 6,7-dihydro-7-hydroxy-12H-phthalazino<2,1-b><2,4>benzodiazocin-12-one (5) and 2-(2-formylbenzoyl)-1-hydrazono-1,2-dihydrophthalazine (6) were the products of the reaction of 1 with 2 in aqueous medium.Upon prolonged standings this mixture converts into 3-(2-carboxyphenyl)-s-triazolo<3,4-a>phthalazine (8).In contrast, the isomeric ring-chain tautomers 2-(1-aminophthalazino)-3-hydroxy-1-oxoisoindole (12) and 1-<2-(2-formylbenzoyl)hydrazino>phthalazine (13) were formed when the reaction was run in ethanol as solvent.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1436O – PubChem

Reference of 4265-25-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4265-25-2, 2-Methylbenzofuran, introducing its new discovery.

The decomposition of 2-isopropylphenol (IPP) was studied in supercritical water at 723-823 K with a water density of 0-0.5 g/cm3 in the absence of catalyst. The main products were phenol, 2-propylphenol (PP), 2-cresol and 2-ethylphenol. The reaction was determined to proceed as follows. At first, the dealkylation and rearrangement of IPP yielded phenol and PP, respectively. Next, the dealkylation of PP lead to the formation of 2-cresol and 2-ethylphenol. The conversion of IPP and the selectivity of phenol increased with the increasing water density, which led to an increase in the yield of phenol. The recoveries of phenol as high as 43% can be obtained in the high water density (0.5 g/cm3) region at 773 K. The rate constant for decomposition of IPP was correlated with a global reaction model for a range of temperatures from 613 to 823 K.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 4265-25-2. In my other articles, you can also check out more blogs about 4265-25-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H264O – PubChem

Related Products of 125-20-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 125-20-2, Name is Thymolphthalein,introducing its new discovery.

A novel organogel that is dually responsive to pH and Li+ was facilely constructed from mixtures of beta-cyclodextrin, thymolphthalein and sodium formate in N,N-dimethylacetamide. Acidity (pH) can trigger a color change of the organogels between a transparent colorless state and a dark-blue state due to the presence of thymolphthalein. It is interesting that Li+ could decompose the gel system while Na+ and K+ do not disturb the gelatinous state. Scanning electron microscopy (SEM) images show that these organogels are composed of fibrous structures. These organogels possess relatively high viscoelasticity indicated by rheology measurements. A mechanism for the gel formation is proposed based on the results of X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The systems could be expected to act as non-liquid materials for sensing with the naked eye. The Royal Society of Chemistry 2013.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4419O – PubChem

Application of 54450-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.54450-20-3, Name is 5-Bromobenzofuran-3(2H)-one, molecular formula is C8H5BrO2. In a Patent，once mentioned of 54450-20-3

The present invention provides a composition for diagnosing amyloid-related diseases, comprising a compound represented by general formula (I): wherein X represents O or the like; R1, R3, R4, R5, R6, R8 and R9 represent a hydrogen atom or the like; R2 represents a halogen atom or the like; and R7 represents a dimethylamino group or the like; or the compound labeled with a radionuclide, or a pharmaceutically acceptable salt of the compound or the labeled compound. The compound represented by general formula (I) has all of the following properties: high binding specificity to amyloid beta protein, high permeability through the blood-brain barrier, and rapid clearance from sites without senile plaques in the brain.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 54450-20-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3600O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C9H8O. Introducing a new discovery about 4265-25-2, Name is 2-Methylbenzofuran

Fast pyrolysis of a lignite containing a high content of oxygen was investigated to understand the effects of pyrolysis temperature and gas resident time on the yields of pyrolysis products and the distributions of organic oxygen species (OOSs). OOSs in the lignite contain carboxyl, carbonyl, hydroxyl and ether by the results of XPS and FTIR analyses. The tar yield reached the maximum of 15.3% at 500 C and a gas resident time of 2.5 s. CO2 was found to be the predominant oxygenous gas at 600 C, and the significant release of CO2 at temperatures lower than 400 C should be related to the high carboxyl content in the lignite. The CO yield increased significantly with the raising temperature and reached 46.4 mL/g (daf) at 700 C. The O yield in water was lower than 20% during pyrolysis at 200 C, and sharply increased to 30.6% at 700 C because of thermal cracking of volatiles. Above 400 C, the OOSs are mainly released as pyrolysis water and gas. The OOSs detected in the tar include phenols, ketones, ethers, alcohols, and dibenzofuran and its substitute, among which phenols (phenol, cresol, and xylenol) are the main components with yield up to 27.1% (based on tar) at 500 C and gas residence time of 10 s. The possible oxygen transformation routes for BYHL pyrolysis are also discussed in this work. Such an approach may lead to the development of efficient lignite upgrading technology.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C9H8O, you can also check out more blogs about4265-25-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H100O – PubChem

Electric Literature of 4741-62-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4741-62-2, Name is 5-Methoxyisobenzofuran-1(3H)-one,introducing its new discovery.

A new series of donepezil analogues based on the phthalazin-1(2H)-one scaffold was designed and synthesized with the aim of exploring its potential as human ChEIs. Biological results revealed that the structural modifications proposed significantly affected ChE inhibitory potency as well as selectivity for AChE/BuChE. Compound 1d showed promising in vitro inhibition of both enzymes in the muM range. However, most target compounds were significantly more active against AChE than BuChE, specifically 1f, 1h and 1j, with IC50 values in the low micromolar or submicromolar range, the most active compounds in the series. Docking simulations suggested that the most active compounds can recognize the donepezil binding site using a similar interactions network. These results allowed us to rationalize the observed structure-activity relationships. Moreover, the predicted physicochemical and ADME properties were also comparable to those of donepezil.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2274O – PubChem

Related Products of 125-20-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 125-20-2, Name is Thymolphthalein,introducing its new discovery.

Methods of inhibiting undesired angiogenesis are provided, which methods include administering to a subject a therapeutically effective amount of at least one of the compounds described herein, or a pharmaceutically acceptable salt thereof.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4256O – PubChem

Electric Literature of 1280665-55-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1280665-55-5, molcular formula is C10H11NO3, introducing its new discovery.

The invention discloses a preparation method of Plk (Polo-like kinase) inhibitor drug intermediate 7-amino-2,3-dihydrobenzofuran-4-formic acid (I), which comprises the following steps: by using 3-hydroxy-4-nitrobenzoic acid as a starting material, firstly esterifying, then condensing the starting material with 2-halogeno acetaldehyde or 2-halogeno acetal under the effect of an alkali acid-binding agent to realize alkylation of hydroxyl, then performing Friedel-Crafts reaction under the catalysis of protonic acid or Lewis acid, performing cyclization to obtain 7-nitrobenzofuran-4-methyl formate, and finally performing catalytic and hydride reduction and hydrolysis to obtain high-yield 7-amino-2,3-dihydrobenzofuran-4-formic acid (I). According to the invention, the synthetic route is simplified and optimized, the reaction processes are reduced, the technology is simplified, the cost is lowered and the production yield is high, and the 7-amino-2,3-dihydrobenzofuran-4-formic acid can be produced in large scale to meet the usage requirements, and is suitable for industrial production.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1280665-55-5 is helpful to your research. Electric Literature of 1280665-55-5

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3119O – PubChem