Category: benzofurans

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2923-28-6, is researched, SMILESS is O=S(C(F)(F)F)([O-])=O.[Ag+], Molecular CAgF3O3SJournal, Article, Chemistry – A European Journal called A Molecular Low-Coordinate [Fe-S-Fe] Unit in Three Oxidation States, Author is Schneider, Christian; Demeshko, Serhiy; Meyer, Franc; Werncke, C. Gunnar, the main research direction is crystal structure iron sulfide methylsilylamido crown ether complex preparation; electrochem antiferromagnetic exchange dinuclear iron sulfido amido complex; oxidation nitrogenase cofactor model iron silylamido complex; 57Fe Mössbauer spectroscopy; electrochemistry; iron sulfide complex; magnetism; nitrogenase.COA of Formula: CAgF3O3S.

A [Fe-S-Fe] subunit with a single sulfide bridging two low-coordinate iron ions is the supposed active site of the iron-molybdenum co-factor (FeMoco) of nitrogenase. Here the authors report a dinuclear monosulfido bridged diiron(II) complex with a similar complex geometry that can be oxidized stepwise to diiron(II/III) and diiron(III/III) complexes while retaining the [Fe-S-Fe] core. The series of complexes has been characterized crystallog., and electronic structures have been studied using, inter alia, 57Fe Mossbauer spectroscopy and SQUID magnetometry. Further, cleavage of the [Fe-S-Fe] unit by CS2 is presented.

After consulting a lot of data, we found that this compound(2923-28-6)COA of Formula: CAgF3O3S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C6H3FN2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors. Author is Yeh, Vince S. C.; Patel, Jyoti R.; Yong, Hong; Kurukulasuriya, Ravi; Fung, Steven; Monzon, Katina; Chiou, William; Wang, Jiahong; Stolarik, Deanne; Imade, Hovis; Beno, David; Brune, Michael; Jacobson, Peer; Sham, Hing; Link, J. T..

A series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biol. evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.

After consulting a lot of data, we found that this compound(3939-12-6)Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: CAgF3O3S. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Silver(I) bis(phosphanylamino)naphthalene complexes: Synthesis, structures and density functional theory (DFT) calculations. Author is Potwana, Fezile S. W.; Pillay, Michael N.; Staples, Richard J.; Adeniyi, Adebayo A.; Singh, Parvesh; van Zyl, Werner E..

A series of five bis(phosphanylamino)naphthalene [C10H6(1,8-NHPPh2)2] (L1) and thio product, [C10H6(1,8-NHP(S)Ph2)2] (L2) containing silver(I) centers are reported. Treatment of silver(I) halides AgX (X = Cl, Br) with (L1) produced complexes of the type [Ag2(μ-X)2{C10H6(1,8-NHPPh2)2}2] where X = Cl (1), Br (2). Changing the M:L ratio to 2:1, the salt AgI produced a complex of the type [Ag4(μ3-I)2(μ2-I)2{C10H6(1,8-NHPPh2)2}2] (3). The reaction between AgOTf (OTf = triflate) and (L2) (molar ratio 1:2) produced the solvated cationic complex [Ag{C10H6(1,8-NHPPh2S)2}2]CF3SO3 (4), while changing from OTf to other anions proved to have no influence in forming cationic complexes but instead led to deprotonation of the ligand and produced a neutral complex [Ag2(μ-S)2{C10H6(1,8-NHPPh2S)}2] (5). The 31P NMR spectra of Ag(I) complexes (1-3) showed two doublets due to coupling of the 31P and 109Ag nuclei. MO and addnl. TD-DFT and spin-orbital coupling calculations were performed to provide more insight into the relevant bond orders and provided a possible explanation for solid-state non-luminescence.

After consulting a lot of data, we found that this compound(2923-28-6)Formula: CAgF3O3S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tautomeric equilibria of heterocyclic molecules. A test of the semiempirical AM1 and MNDO-PM3 methods, published in 1991-02-28, which mentions a compound: 134434-31-4, mainly applied to tautomerism lactam lactim MO; AM1 tautomerism heterocycle; MNDO PM3 tautomerism heterocycle, Synthetic Route of C9H7NO.

Tautomeric equilibrium (mainly of the lactam-lactim type) for a rather large number of six-membered heterocyclic mols. are calculated by the semiempirical AM1, MNDO-PM3, and MNDO methods. Except for compounds with adjacent pyridine-like lone pairs both AM1 as well as MNDO-PM3 give rather reliable predictions for relative stabilities of the various tautomeric species, comparable to quite high level ab initio calculations The known Errors associated with MNDO in the treatment of heterocyclic tautomerism are thus largely corrected in AM1 as well as MNDO-PM3. For 2-hydroxypyridine-pyrid-2(1H)-one the effect of self-association is less satisfactorily described by MNDO-PM3 than by AM1. MNDO-PM3 calculated relative stabilities of methylated derivatives are, however, in considerably closer agreement with exptl. values than those obtained by AM1. Ionization potentials, especially those for lone-pair orbitals, are overestimated by all three semiempirical methods. MNDO-PM3 results for nitrogen lone-pair orbital energies are slightly better than those obtained by the AM1 or MNDO method.

After consulting a lot of data, we found that this compound(134434-31-4)Synthetic Route of C9H7NO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2923-28-6, is researched, SMILESS is O=S(C(F)(F)F)([O-])=O.[Ag+], Molecular CAgF3O3SJournal, Article, Inorganic Chemistry called Physicochemical Factors That Influence the Deoxygenation of Oxyanions in Atomically Precise, Oxygen-Deficient Vanadium Oxide Assemblies, Author is Petel, Brittney E.; Matson, Ellen M., the main research direction is oxygen deficient polyoxovanadate electrochem oxygen atom transfer rate.Synthetic Route of CAgF3O3S.

Here, the authors report the findings related to the structural and electronic considerations that influence the rate of oxygen-atom transfer (OAT) to oxygen-deficient polyoxovanadate alkoxide (POV-alkoxide) clusters ([V6O6(OC2H5)12]n; n = 1-, 0, 1 + ). A comparison of the reaction times required for the reduction of nitrogen-containing oxyanions (NOx-, x = 2, 3) by the POV-ethoxide cluster in its anionic (1-V6O61-; VIIIVIV5), neutral (4-V6O60; VIIIVIV4VV), or cationic (6-V6O61+; VIIIVIV3VV2) charge state reveals that OAT is significantly influenced by three factors: (1) ion-pairing interactions between the POV-alkoxide and the neg. charged oxyanion; (2) oxidation states of remote vanadyl ions in the Lindqvist assembly; (3) the steric bulk surrounding the coordinatively unsaturated VIII ion. This work provides at.-level insight related to structure-function relations that govern the rate of OAT at metal oxide surfaces using polyoxometalate clusters as mol. models. Investigation of the properties that influence the oxygen-atom-transfer (OAT) rate from nitrogen-containing oxyanions to oxygen-deficient polyoxovanadate alkoxide clusters revealed that remote redox changes, ion-pairing interactions, and the steric bulk of surface ligands all effect OAT. Using these mol. models for bulk vanadium oxides, these studies reveal the physicochem. properties that may similarly impact the reactivity of metal oxide materials.

After consulting a lot of data, we found that this compound(2923-28-6)Synthetic Route of CAgF3O3S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Fluoronicotinonitrile(SMILESS: N#CC1=CC=C(F)N=C1,cas:3939-12-6) is researched.Synthetic Route of CAgF3O3S. The article 《Regulating force-resistance and acid-responsiveness of pure organics with persistent phosphorescence via simple isomerization》 in relation to this compound, is published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. Let’s take a look at the latest research on this compound (cas:3939-12-6).

Stimulus-responsive purely organic room-temperature phosphorescence materials have been drawing massive attention due to their wide applications. Pyridine rings are introduced to supply π orbitals and cyanogroups are incorporated to boost the ISC efficiency by promoting the spin-forbidden transition. These groups are anticipated to enable the target mol. with multi-responsiveness because of the protonation of pyridine and their good crystallinity, which are able to regulate the acid-responsiveness and force-responsiveness, resp. Based on the above design concept, four new D-A-A’ type mols. using carbazole as the donor and the pyridine ring and cyanogroup as acceptors were designed and synthesized. The D-A-A’ structure bestows these isomers with an evident intramol. charge transfer (ICT) feature, particularly for 2-CNPyCZ and 3-CNPyCZ. All the isomers show intense long-lived phosphorescence with a lifetime over 500 ms. Particularly, 4-CNPyCZ has a high phosphorescence quantum yield of 27.1% owing to the strong intermol. interactions that stabilize the T*1 excitons. Interestingly, four isomers could retain their long-lived afterglow even after being heavily ground and the afterglow shows well resistance to external forces due to high crystallinity. 4-CNPyCZ manifests unique mechanochromism owing to the fluorescence shift and intensity change of phosphorescence. Moreover, the four isomers demonstrate distinctive acid-responsiveness and give out colorful emissions because the electron cloud dispersion of the nitrogen atom in the pyridine ring varied when altering the position of the cyanogroup. To the best of our knowledge, this is a limited work on room temperature phosphorescence about systematically regulating the responsiveness to external stimuli and proposing an effective mol. design strategy.

After consulting a lot of data, we found that this compound(3939-12-6)COA of Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2923-28-6, is researched, Molecular CAgF3O3S, about N→Ge Coordinated Germylenes as Ligands for Monomeric Cu Complexes, the main research direction is copper aryl amino germanium germylene complex preparation crystal structure; cyclic voltammetry copper aryl amino germanium germylene complex.Reference of Silver(I) trifluoromethanesulfonate.

Synthesis of monomeric Cu complexes stabilized by the N→Ge coordinated germylene L(Cl)Ge (L = 2-Et2NCH2-4,6-tBu2-C6H2) is reported. The reactions of the [L(Cl)Ge]2CuI (1) with AgX provided the complexes [L(Cl)Ge]2CuX (X = 2: X = OAc, 3: X = OTf) by selective substitution of the CuI bond. In contrast, the reaction of 1 with K[BEt3H] provided [L(H)Ge]2CuI (4), the product of selective substitution of the GeCl bonds. The 4 represents the first example of Cu complex stabilized by two organogermaniun hydrides [L(H)Ge].

After consulting a lot of data, we found that this compound(2923-28-6)Reference of Silver(I) trifluoromethanesulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Product Details of 2923-28-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2′:6′,2”-terpyridine ligands: From in vitro to in vivo biological properties. Author is Choroba, Katarzyna; Machura, Barbara; Szlapa-Kula, Agata; Malecki, Jan G.; Raposo, Luis; Roma-Rodrigues, Catarina; Cordeiro, Sandra; Baptista, Pedro V.; Fernandes, Alexandra R..

Cancer is the second leading cause of death worldwide. Cisplatin has challenged cancer treatment; however, resistance and side effects hamper its use. New agents displaying improved activity and more reduced side effects relative to cisplatin are needed. The authors present the synthesis, characterization and biol. activities of three complexes with quinoline-substituted 2,2′:6′,2”-terpyridine ligand: [Pt(4′-(2-quin)-terpy)Cl](SO3CF3) (1), [Au(4′-(2-quin)-terpy)Cl](PF6)2·CH3CN (2) and [Cu(4′-(2-quin)-terpy)Cl](PF6) (3). The three complexes displayed a high antiproliferative activity in ovarian carcinoma cell line (A2780) and even more noticeable in a colorectal carcinoma cell line (HCT116) following the order 3 > 2 > 1. The complexes IC50 are at least 20 x lower than the IC50 displayed by cisplatin (15.4μM) in HCT116 cell line while displaying at the same time, much reduced cytotoxicity in a normal dermal fibroblast culture. These cytotoxic activities seem to be correlated with the inclination angles of 2-quin unit to the central pyridine. All complexes can interact with calf-thymus DNA (CT-DNA) in vitro via different mechanisms, although intercalation seems to be the preferred mechanism at least for 2 and 3 at higher concentrations of DNA. Also, CD data seems to indicate that complex 3, more planar, induces a high destabilization of the DNA double helix (shift from B-form to Z-form). Higher the deviation from planar, the lower the cytotoxicity displayed by the complexes. Cellular uptake may be also responsible for the different cytotoxicity exhibited by complexes with 3 > 2 >1. Complex 2 seems to enter cells more passively while complex 1 and 3 might enter cells via energy-dependent and -independent mechanisms. Complexes 1-3 induce ROS are associated with the increased apoptosis and autophagy. Also, all complexes dissipate the mitochondrial membrane potential leading to an increased BAX/BCL-2 ratio that triggered apoptosis. Complexes 2 and 3 also exhibit an anti-angiogenic effect by significantly reduce the number of newly formed blood vessel in a CAM model with no toxicity in this in vivo model. The results seem to suggest that the increased cytotoxicity of complex 3 in HCT116 cells and its potential interest for further translation to pre-clin. mice xenografts might be associated with: (1) higher % of internalization of HCT116 cells via energy-dependent and -independent mechanisms; (2) ability to intercalate DNA and due to its planarity induced higher destabilization of DNA; (3) induce intracellular ROS that trigger apoptosis and autophagy; (4) low toxicity in an in vivo model of CAM; (5) potential anti-angiogenic effect.

Although many compounds look similar to this compound(2923-28-6)Product Details of 2923-28-6, numerous studies have shown that this compound(SMILES:O=S(C(F)(F)F)([O-])=O.[Ag+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shi, An-Guo; Deth, Richard C. researched the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3 ).Formula: C18H20N2O12.They published the article 《Precoupling of alpha-2B adrenergic receptors and G-proteins in transfected PC-12 cell membranes: influence of pertussis toxin and a lysine-directed cross-linker》 about this compound( cas:70539-42-3 ) in Journal of Pharmacology and Experimental Therapeutics. Keywords: alpha2B adrenergic receptor precoupling G protein. We’ll tell you more about this compound (cas:70539-42-3).

The ability of pertussis toxin (PTX) pretreatment to alter the binding of [3H]rauwolscine (RAU) to alpha-2B adrenergic receptors expressed in PC12 cells was examined PTX caused a 30% increase in the Bmax for [3H]RAU and reduced its KD, whereas in the added presence of Na+ and Gpp(NH)p binding was increased to 75% above the level in untreated membranes. Because all three agents act to reduce receptor/G-protein affinity, the increased binding may reflect extensive precoupling of the alpha-2B receptor. The affinity of the agonist epinephrine in displacing [3H]RAU was normally reduced by both Na+ and Gpp(NH)p; however, in PTX-treated membranes the effect of Gpp(NH)p was eliminated, and Na+ remained effective. The lysine-directed crosslinking reagent ethyleneglycol bis(succinimidyl)succinate (EGS) was utilized to cross-link precoupled receptor and G-protein. Maximal [3H]RAU binding was reduced by EGS in a time- and dose-dependent manner, and this action was reversed by prior incubation with Na+ and Gpp(NH)p, suggesting that EGS did indeed cross-link receptor and G-protein. RAU and epinephrine each provided protection against the effect of EGS. The inclusion of Na+ and Gpp(NH)p during [3H]RAU binding studies was able to restore maximal binding in EGS-treated membranes to the same level as untreated membranes. These results indicate that in the absence of Na+ and Gpp(NH)p at least 40% of the total alpha-2B adrenergic receptors in these membranes exist as a precoupled receptor/G-protein complex which fails to bind [3H]RAU.

Although many compounds look similar to this compound(70539-42-3)Formula: C18H20N2O12, numerous studies have shown that this compound(SMILES:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ) is researched.HPLC of Formula: 2923-28-6.Sinha, Soumalya; Tran, Giang N.; Na, Hanah; Mirica, Liviu M. published the article 《Electrocatalytic H2 evolution promoted by a bioinspired (N2S2)Ni(II) complex at low acid concentration》 about this compound( cas:2923-28-6 ) in ChemRxiv. Keywords: nickel electrocatalyst hydrogen evolution reaction. Let’s learn more about this compound (cas:2923-28-6).

The electrochem. hydrogen evolution reaction (HER) is of great interest to advance fuel cell technologies. Although heterogeneous HER electrocatalysts are desired for practical energy devices, the development of mol. electrocatalysts is important to elucidate the mechanism and improve the activity of state-of-the-art HER catalysts. Inspired by the enzymic HER process promoted by [NiFe] hydrogenases, we synthesized a bioinspired NiII electrocatalyst that produces H2 from CF3CO2H at low acid concentrations (<0.043 M) in MeCN. Under these conditions, the turnover frequency for HER achieved herein is ~200,000 s-1. We propose that our NiII electrocatalyst follows a novel HER mechanism by undergoing a 2e- transfer process in a single step, followed by stepwise H+ transfer at low acid concentrations, and the increase in acid concentration changes the HER mechanism toward a concerted H+/e- transfer. Finally, we evaluated the HER activity of our catalyst by benchmarking its kinetic and thermodn. parameters vs. other reported HER electrocatalysts. Although many compounds look similar to this compound(2923-28-6)HPLC of Formula: 2923-28-6, numerous studies have shown that this compound(SMILES:O=S(C(F)(F)F)([O-])=O.[Ag+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem