Category: benzofurans

Quality Control of 1,3-DiphenylisobenzofuranIn 2021 ,《A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy》 was published in Advanced Materials (Weinheim, Germany). The article was written by Liang, Shuang; Liu, Bin; Xiao, Xiao; Yuan, Meng; Yang, Ling; Ma, Ping’an; Cheng, Ziyong; Lin, Jun. The article contains the following contents:

The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4) nanodendrites with a narrower bandgap (compared with the most extensively explored sonosensitizers) are presented as a new source of sonosensitizer, which allows a more effortless separation of sono-triggered electron-hole pairs for ROS generation. Specifically, platinum (Pt) nanoparticles and endogenous high levels of glutathione (GSH) are rationally engineered to further optimize its sono-sensitized performance. As cocatalyst, Pt is conducive to trapping electrons, whereas GSH, as a natural hole-scavenger, tends to capture holes. Compared with the pristine VS4 sonosensitizer, the GSH-Pt-VS4 nanocomposite can greatly prolong the lifetime of the charge and confer a highly efficacious ROS production activity. Furthermore, such nanoplatforms are capable of reshaping tumor microenvironments to realize ROS overproduction, contributed by overcoming tumor hypoxia to improve SDT-triggered singlet oxygen production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals for chemodynamic therapy, and depleting GSH to amplify intratumoral oxidative stress. All these combined effects result in a significantly efficient tumor suppression outcome. This study enriches sonosensitizer research and proves that sonosensitizers can be rationally optimized by charge separation engineering strategy. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Quality Control of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Quality Control of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 5471-63-6In 2021 ,《Porous polymers from octa(amino-phenyl)silsesquioxane and metalloporphyrin as peroxidase-mimicking enzyme for malathion colorimetric sensor》 appeared in Colloids and Surfaces, B: Biointerfaces. The author of the article were Guo, Xiaojun; Chen, Mohan; Jing, Lu; Li, Jie; Li, Yanhong; Ding, Rui; Zhang, Xiaomei. The article conveys some information:

Rapid and efficient pesticide detection methods are particularly important due to the growing problems of pesticide residues. Here, a new azo-based porous organic polymer, Azo(Fe)PPOP, was prepared from octa(amino-phenyl)silsesquioxane (OAPS) and iron(III) 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (FeTPP(NO2)4) via a simple coupling reaction without the participation of metal catalysts. The inorganic cage units of OAPS endowed Azo(Fe)PPOP a porous framework, high surface area, favorably thermal and chem. stability. In Azo(Fe)PPOP, iron(III) porphyrin units were individually isolated in a fixed location, which could effectively avoid dimerization or self-oxidation as happens as in the case of porphyrin monomers. Such a unique structure made Azo(Fe)PPOP exhibit an excellent peroxidase-like catalytic performance in the presence of H2O2 and 3,3′,5,5′-tetramethylbenzidine (TMB). Because of these advantages, we established a selective, facile, and sensitive colorimetric platform for direct detection of malathion within a very short time (3 min) with a low detection limit (8.5 nM). In addition, the recognition mechanism between Azo(Fe)PPOP and malathion was verified using XPS spectra. The practicality of the constructed platform was further executed by the detection of the pesticide in soil and food samples. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Loukhina, I. V.; Gradova, M. A.; Khudyaeva, I. S.; Lobanov, A. V.; Belykh, D. V. published their research in Russian Journal of General Chemistry in 2021. The article was titled 《Synthesis and photocatalytic properties of magnesium silicate modified with cationic chlorin e6 derivatives》.Electric Literature of C20H14O The article contains the following contents:

Synthetic samples of layered magnesium silicate modified with mono-, di-, and tricationic chlorin e6 derivatives have exhibited comparable photochem. activity towards a series of reductants: 1,3-diphenylisobenzofuran selectively oxidizable with singlet oxygen and 1,2-phenylenediamine readily oxidizable with hydrogen peroxide. The optimal photochem. activity of the modified magnesium silicates has been achieved at the ratio of 4-8 μmol of chlorin e6 derivative per 1 g of magnesium silicate. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Capture and Release of Singlet Oxygen in Coordination-Driven Self-Assembled Organoplatinum(II) Metallacycles》 was published in Journal of the American Chemical Society in 2020. These research results belong to He, Yan-Qin; Fudickar, Werner; Tang, Jian-Hong; Wang, Heng; Li, Xiaopeng; Han, Jun; Wang, Zhengping; Liu, Min; Zhong, Yu-Wu; Linker, Torsten; Stang, Peter J.. COA of Formula: C20H14O The article mentions the following:

Singlet oxygen (1O2), as an important active reagent, has found wide applications in photodynamic therapy (PDT), synthetic chem., and materials science. Organic conjugated aromatics serving as hosts to capture and release singlet oxygen have been systematically investigated over the last decades. Herein, we present a [6 + 6] organoplatinum(II) metallacycle by using ∼180° dipyridylanthracene donor and ∼120° Pt(II) acceptor as the building blocks, which enables the capture and release of singlet oxygen with relatively high photooxygenation and thermolysis rate constants The photooxygenation of the metallacycle to the corresponding endoperoxide was performed by sensitized irradiation, and the resulting endoperoxide is stable at room temperature and can be stored under ambient condition over months. Upon simple heating of the neat endoperoxide under inert atm. at 120°C for 4 h, the resulting endoperoxide can be reconverted to the corresponding parent form and singlet oxygen. The photooxygenation and thermolysis products were characterized by NMR spectroscopy and electrospray ionization time-of-flight mass spectrometric anal. D. functional theory calculations were conducted in order to reveal the frontier MO interactions and reactivity. This work provides a new material platform for singlet oxygen related promising applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xue, Si-tu; Zhang, Lei; Xie, Zhuo-song; Jin, Jie; Guo, Hui-Fang; Yi, Hong; Liu, Zong-ying; Li, Zhuo-rong published their research in European Journal of Medicinal Chemistry on August 15 ,2020. The article was titled 《Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model and ADME properties》.Computed Properties of C12H12O4 The article contains the following contents:

This study optimized the structure of the anti-osteoporosis compound I [R1 = H; R2 = OMe; R5 = OEt; X = O] by balancing its lipophilicity and improving its stability. Substituted benzothiophenes/benzofurans derivatives I [R1 = H; R2 = OMe; R1R2 = OCH2O; R5 = Cl, OH, OEt; X = O, S] and II [R1 = H; R2 = OMe; R1R2 = OCH2O; R3 = n-Pr, P(O)(OH)2, CH2N(CH3)2, etc.; X = O, S; Y = O, NH, NMe] which were not reported in the literature were designed and synthesized. The ovariectomized rat model of osteoporosis was selected to evaluate the therapeutic effects, compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] showed better therapeutic efficacy than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. The anti-osteoporosis activity and BMP-2 (bone morphogenetic protein-2) protein upregulation after treatment with compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] in a zebrafish osteoporosis model was verified. Compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] improved the ADME properties, therapeutic efficacy and pharmacokinetics of the drug than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. Overall, the anti-osteoporosis effects of the compounds I and II of this type, preliminarily determined the target patient population, verified the mechanism of action, clarified the level of toxicity and provided preliminary ADME data was evaluated. These compounds I and II could both correct bone loss that was already occurring in patients and had broad clin. applicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Computed Properties of C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Computed Properties of C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Madridejos, Jenica Marie L.; Harada, Takaaki; Falcinella, Alexander J.; Small, Thomas D.; Golovko, Vladimir B.; Andersson, Gunther G.; Metha, Gregory F.; Kee, Tak W. published an article in 2021. The article was titled 《Optical Properties of the Atomically Precise C4 Core [Au9(PPh3)8]3+ Cluster Probed by Transient Absorption Spectroscopy and Time-Dependent Density Functional Theory》, and you may find the article in Journal of Physical Chemistry C.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Structural isomerism of [Au9(PPh3)8]3+ has been studied exptl., mostly concerning the symmetry of the Au9 core. Recently, the C4 isomer of [Au9(PPh3)8]3+ has been shown to exist in solution phase while the D2h isomer is present in the solid state [Inorganic Chem.2017, 56, 8319-8325]. In this work, geometric, electronic, and optical properties of C4 [Au9(PPh3)8]3+ are investigated by using the combined second-order d.-functional tight-binding (DFTB2) method and time-dependent d. functional theory (TD-DFT) calculations with spin-orbit coupling. Addnl., the excited-state relaxation dynamics of the [Au9(PPh3)8]3+ cluster in dichloromethane and methanol solutions are studied using femtosecond transient absorption spectroscopy. [Au9(PPh3)8]3+ is optically pumped to different excited states by using 432, 532, and 603 nm light. For all three pump wavelengths, the photoexcitation event induces an excited-state absorption (ESA) band centered at 600 nm with decay time constants of 2.0 and 45 ps, which are attributed to intersystem crossing and nonradiative relaxation of [Au9(PPh3)8]3+, resp. On the other hand, optical pumping of [Au9(PPh3)8]3+ using 432 nm light gives rise to an addnl. ESA band at 900 nm. This band exhibits fast relaxation through internal conversion with a time constant of ~0.3 ps. Our combined computational and exptl. study reveals that the excitation wavelength-dependent relaxation dynamics of the [Au9(PPh3)8]3+ cluster are related to the different electron densities of the excited states of [Au9(PPh3)8]3+, consistent with it possessing mol.-like electronic states. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synthesis of 2-amino-4-(2-benzofuryl)-Δ1-pyrrolines and study of their antiarrhythmic properties》 was written by Maillard, Jacques; Langlois, Michel; Tri, Vo Van; Guillonneau, Claude; Legeai, Jacques; Benharkate, Marguerite; Blozovski, Mladen. Quality Control of 6-Methoxybenzofuran-2-carbaldehyde And the article was included in European Journal of Medicinal Chemistry on August 31 ,1983. The article conveys some information:

2-Ethoxy-1-pyrrolines I (R = furyl, thienyl, benzofuryl, benzothienyl) were converted to amino analogs II (R1 = H, alkyl; R2 = H, alkyl, allyl, propargyl, CH2CH2OH, CH2CH2NMe2, phenethyl, Ph, OMe, OCH2Ph; or NR1R2 = pyrrolidino, morpholino, 4-methyl-1-piperazinyl), which showed antiarrhythmic activity. I (R = 2-benzofuryl) was heated with Me2NH.HCl in EtOH to give II (R = 2-benzofuryl, R1 = R2 = Me) hydrochloride. The results came from multiple reactions, including the reaction of 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Quality Control of 6-Methoxybenzofuran-2-carbaldehyde)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Quality Control of 6-Methoxybenzofuran-2-carbaldehydeBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Xiang; Wang, Ran; Hu, Yingqi; Liu, Wei Jian; Liu, Ting; Sun, Wen; Fan, Jiangli; Peng, Xiaojun published an article in 2021. The article was titled 《A novel photosensitizer for lipid droplet-location photodynamic therapy》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biol. processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet-targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging-guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet-location PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photocatalytic degradation of tetracycline by a novel (CMC)/MIL-101(Fe)/β-CDP composite hydrogel》 was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2020. These research results belong to Zhang, Hui; Zhou, Liang; Li, Jing; Rong, Sijia; Jiang, Jianping; Liu, Shengquan. Computed Properties of C20H14O The article mentions the following:

Herein, we report a novel CM-cellulose (CMC)/MIL-101 (Fe)/poly(β-cyclodextrin) (β-CDP) hydrogel with high photocatalytic activity. β-CDP can significantly enhance the photoactivity of MIL-101(Fe) in the hydrogel prepared by a simple solvothermal method. The structure and property of this composite hydrogel were characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, and transmission electron microscopy. Tetracycline was selected as a model pharmaceutical antibiotic to evaluate the photocatalytic activity of the composite hydrogel under visible light irradiation and darkness, resp. This composite hydrogel shows excellent activity for degrading pharmaceutical antibiotics under visible light irradiation The increased photocatalytic activity can be attributed to β -CDP, which acts as a promoter and affords an efficient separation of photogenerated electron-hole pairs of MIL-101(Fe). Moreover, the composite hydrogel is shown to have good water retainability. The hydrogel is inexpensive and shows high photocatalytic activity. Hence, it can be used as an efficient photocatalytic material.1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C20H14OIn 2020 ,《Post-synthetically elaborated BODIPY-based porous organic polymers (POPs) for the photochemical detoxification of a sulfur mustard simulant》 appeared in Journal of the American Chemical Society. The author of the article were Atilgan, Ahmet; Cetin, M. Mustafa; Yu, Jierui; Beldjoudi, Yassine; Liu, Jian; Stern, Charlotte L.; Cetin, Furkan M.; Islamoglu, Timur; Farha, Omar K.; Deria, Pravas; Stoddart, J. Fraser; Hupp, Joseph T.. The article conveys some information:

Designing new materials for the effective detoxification of chem. warfare agents (CWAs) is of current interest given the recent use of CWAs. Although halogenated boron-dipyrromethene derivatives (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene or BDP or BODIPY) at the 2 and 6 positions have been extensively explored as efficient photosensitizers for generating singlet oxygen (1O2) in homogeneous media, their utilization in the design of porous organic polymers (POPs) has remained elusive due to the difficulty of controlling polymerization processes through cross-coupling synthesis pathways. Our approach to overcome these difficulties and prepare halogenated BODIPY-based porous organic polymers (X-BDP-POP where X = Br or I) represents an attractive alternative through post-synthesis modification (PSM) of the parent hydrogenated polymer. Upon synthesis of both the parent polymer, H-BDP-POP, and its post-synthetically modified derivatives, Br-BDP-POP and I-BDP-POP, the BET surface areas of all POPs have been measured and found to be 640, 430, and 400 m2·g-1, resp. In addition, the insertion of heavy halogen atoms at the 2 and 6 positions of the BODIPY unit leads to the quenching of fluorescence (both polymer and solution-phase monomer forms) and the enhancement of phosphorescence (particularly for the iodo versions of the polymers and monomers), as a result of efficient intersystem crossing. The heterogeneous photocatalytic activities of both the parent POP and its derivatives for the detoxification of the sulfur mustard simulant, 2-chloroethyl Et sulfide (CEES), have been examined; the results show a significant enhancement in the generation of singlet oxygen (1O2). Both the bromination and iodination of H-BDP-POP served to shorten by 5-fold of the time needed for the selective and catalytic photo-oxidation of CEES to 2-chloroethyl Et sulfoxide (CEESO). The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem