Category: benzofurans

In 2022,Zhang, Rui; Liu, Changlin; Zhao, Ruoxi; Du, Yaqian; Yang, Dan; Ding, He; Yang, Guixin; Gai, Shili; He, Fei; Yang, Piaoping published an article in Journal of Colloid and Interface Science. The title of the article was 《Engineering oxygen vacancy of MoOx nanoenzyme by Mn doping for dual-route cascaded catalysis mediated high tumor eradication》.SDS of cas: 5471-63-6 The author mentioned the following in the article:

There is an urgent need to develop photosensitive nanoenzymes with better phototherapeutic efficiency through simple processes. By exploiting semiconductor catalysis and defect chem. principles, herein, a MnMoOx composite semiconductor nanoenzyme was developed to achieve a fully integrated theranostic nanoenzyme for highly efficient photo/chemo-enzyme-dynamic eradication of deep tumors. Relative to iron oxides, manganese oxides offer ideal catalytic performance under near-neutral conditions, which helps to broaden the suitable pH range of the MnMoOx nanoenzyme for antitumor therapy. Furthermore, with the assistance of glutathione depletion, Mn4+/Mo6+ was successfully converted to Mn2+/Mo5+, inhibiting the scavenging of reactive oxygen species (ROS) and promoting cycling. Therefore, MnMoOx has favorable catalase (CAT)-like activity and oxidase (OXD)-like activity in the tumor microenvironment (TME) for promoting the “”H2O2-O2-·O2-“” and “”H2O2-·OH”” cascade reactions. The abundant oxygen vacancy defects also promote the surface plasmon resonance (SPR) effect in the second near-IR (NIR-II) window of MnMoOx, which significantly enhanced its photothermal therapy (PTT) effect and catalytic activity. In detail, ROS production was significantly enhanced due to the adsorption of water and oxygen mols. by the rich oxygen vacancies of MnMoOx. MnMoOx also exhibited excellent multi-modal imaging activity (including computed tomog. (CT), magnetic resonance imaging (MRI), and photoacoustic (PA)), which can be exploited to better guide the administration of medication. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Changyu; Zou, Hai; Yang, Nan; Li, Hui; Cai, Yu; Song, Xuejiao; Shao, Jinjun; Chen, Peng; Mou, Xiaozhou; Wang, Wenjun; Dong, Xiaochen published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy》.SDS of cas: 5471-63-6 The article contains the following contents:

Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving addnl. therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented “”all-in-one”” Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self-replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hirota, Takashi; Fujita, Hiroko; Sasaki, Kenji; Namba, Tetsuto published their research in Journal of Heterocyclic Chemistry on December 31 ,1986. The article was titled 《A novel synthesis of benzofuran and related compounds. III. The Vilsmeier reaction of phenoxyacetaldehyde diethyl acetals》.Application of 53860-74-5 The article contains the following contents:

2-Benzofurancarboxaldehydes, e.g., I (R = H, OMe; R1 = OMe, OEt, NEt2) were prepared in 15-58% yields by the Vilsmeier reaction 3,5-RR1C6H3OCH2CH(OEt)2 (II). A rare geminidiol III was isolated in one case. II were prepared in 65-91% yields by treating 3,5-RR1C6H3ONa with BrCH2CH(OEt)2. In the experiment, the researchers used 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Application of 53860-74-5)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Application of 53860-74-5Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hadi, Marym Mohammad; Nesbitt, Heather; Masood, Hamzah; Sciscione, Fabiola; Patel, Shiv; Ramesh, Bala S.; Emberton, Mark; Callan, John F.; MacRobert, Alexander; McHale, Anthony P.; Nomikou, Nikolitsa published their research in Journal of Controlled Release in 2021. The article was titled 《Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimized sonodynamic therapy in prostate cancer》.Reference of 1,3-Diphenylisobenzofuran The article contains the following contents:

Nano-formulations that are responsive to tumor-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel stimulus-responsive nanoparticulate platform for the targeted treatment of prostate cancer using sonodynamic therapy (SDT). The nanoparticles were prepared by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphyrin. The nanoparticulate formulation was characterized with respect to particle size, morphol., surface charge and singlet oxygen production during ultrasound exposure. The response of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in the tumor microenvironment of many solid tumors, was assessed. Our results showed that digestion with cathepsin B led to nanoparticle size reduction In the absence of ultrasound, the formulation exhibited greater toxicity at acidic pH than at physiol. pH, using the human prostate cells lines LNCaP and PC3 as targets. Nanoparticle cellular uptake was enhanced at acidic pH – a condition that was also associated with greater cathepsin B production Nanoparticles exhibited enhanced ultrasound-induced cytotoxicity against both prostate cancer cell lines. Subsequent proof-of-concept in vivo studies demonstrated that, when ectopic human xenograft LNCaP tumors in SCID mice were treated with SDT using the systemically-administered nanoparticulate formulation at a single dose, tumor volumes decreased by up to 64% within 24 h. No adverse effects were observed in the nanoparticle-treated mice and their body weight remained stable. The potential of this novel formulation to deliver safe and effective treatment of prostate cancer is discussed. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Reference of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Reference of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wei; Liu, Chuang; Ji, Xiaoyuan; Joseph, John; Tang, Zhongmin; Ouyang, Jiang; Xiao, Yufen; Kong, Na; Joshi, Nitin; Farokhzad, Omid C.; Tao, Wei; Xie, Tian published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy》.Name: 1,3-Diphenylisobenzofuran The article contains the following contents:

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non-invasiveness and high tissue-penetrating depth. However, developing biocompatible nanomaterial-based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid-phase exfoliation strategy to obtain a new type of two-dimensional (2D) stanene-based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano-sonosensitizers, allowing a more efficient US-triggered separation of electron (e-)-hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near-IR (NIR)-mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT-enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Name: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Name: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Bianco, Armandodoriano; Guiso, Marcella; Mazzei, Raffaele Antonio; Nano, Giuseppe published an article on January 31 ,1997. The article was titled 《New insights on the reaction of benzofurans with aromatic aldehydes. Synthesis of new triphenylmethane-type dyes》, and you may find the article in Gazzetta Chimica Italiana.Formula: C12H12O4 The information in the text is summarized as follows:

New mols. with a triphenylmethane-type structure have been synthesized based on the structure of colored compounds obtained from natural substrates. Satisfactory yields were obtained from benzofuran derivatives as starting material, which have been condensed in methanol with aromatic aldehydes in the presence of catalytic amounts of mineral acids. Several of the new compounds behave as pH indicators. The condensation products, obtained from suitably functionalized starting products, can be easily oxidized giving rise to new triphenylmethane-type dyes, such as I. In the experiment, the researchers used many compounds, for example, Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Formula: C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Formula: C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Carrier-Free Triterpene Prodrugs with Glutathione Response and Biosafety for Synergistically Enhanced Photochemotherapy》 was written by Cheng, Jianjun; Li, Xinyu; Wang, Shu; Han, Ying; Zhao, Haitian; Yang, Xin. Related Products of 5471-63-6This research focused ontriterpene prodrug glutathione biosafety photochemotherapy; carrier-free; glutathione response; photochemotherapy; self-assembly; triterpene prodrugs. The article conveys some information:

Carrier-free pure drug self-assembled nanosystems have been proposed as a promising strategy for synergetic anticancer therapy. Herein, we purposefully designed and synthesized disulfide-modified glutathione (GSH)-responsive natural pentacyclic triterpene betulinic acid (BA) with better biodegradability and biocompatibility to construct carrier-free photosensitive prodrugs BA-S-S/Ce6 NPs for synergistically enhanced and biosafe photochemotherapy. The mol. dynamics simulation elucidates the possible coassembly mechanism that the coplanar arrangement of BA-S-S dimeric may be primarily responsible for the formation of a long lamella-like or spherical morphol. The d. functional theory calculations demonstrate that the reduced energy gap (ΔEST) of Ce6 facilitates the improved singlet oxygen generation of BA-S-S/Ce6 nanoparticles (NPs). The assembled prodrugs exhibited remarkable GSH-responsive property and multiple favorable therapeutic features, leading to enhanced synergistic antitumor efficacy without noticeable toxicity. Addnl., evaluation of the antitumor efficacy of another tetracyclic triterpene stigmasterol (ST)-mediated ST-S-S/Ce6 NPs further confirmed the effectiveness of this rational design. This work provides a promising insight for exploring the pure drug self-assembly behavior and construction of GSH-responsive carrier-free triterpenoid prodrugs toward improved multiple combination antitumor therapies. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Buchanan, Eric A.; Johnson, Justin C.; Tan, Melissa; Kaleta, Jiri; Shtukenberg, Alexander G.; Bateman, Gage; Benedict, Jason B.; Kobayashi, Shinjiro; Wen, Jin; Kahr, Bart; Cisarova, Ivana; Michl, Josef published their research in Journal of Physical Chemistry C in 2021. The article was titled 《Competing Singlet Fission and Excimer Formation in Solid Fluorinated 1,3-Diphenylisobenzofurans》.Recommanded Product: 5471-63-6 The article contains the following contents:

Singlet fission (kSF) and excimer formation (kEXC) rate constants along with other photophys. properties of thin solid layers of 1,3-diphenylisobenzofuran and 11 of its fluorinated derivatives have been determined The mol. properties of these compounds are similar, but their crystal packing varies widely. Most of them undergo singlet fission whereas excitation in others is trapped in excimers. The trend in rate constants kSF agrees qual. with results of calculations by a simplified version of the frontier orbital model for a mol. pair. The main shortcoming of the model is discussed. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Boykin, David W.; Baumstark, Alfons L.; Kayser, Margaret M.; Soucy, Chantal M. published an article in Canadian Journal of Chemistry. The title of the article was 《Oxygen-17 nuclear magnetic resonance spectroscopic study of substituted phthalic anhydrides and phthalides》.Computed Properties of C8H5IO2 The author mentioned the following in the article:

17O chem. shift data (natural abundance) for 3-substituted phthalic anhydrides and 4- and 7-substituted phthalides in acetonitrile at 75° are reported. Steric interactions of substituents ortho to the carbonyl groups result in deshielding effects (9-22 ppm) relative to parent compounds regardless of the electronic character of the substituents. Factors contributing to the deshielding effects are discussed. The relationship between 17O chem. shifts and regiochem. of the phthalic anhydrides is discussed. In the part of experimental materials, we found many familiar compounds, such as 7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0Computed Properties of C8H5IO2)

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Computed Properties of C8H5IO2Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《The chemistry of 5-oxodihydroisoxazoles. XVI. A new synthesis of pyrroles, furans, thiophenes and their benzo analogs》 was published in Australian Journal of Chemistry in 1996. These research results belong to Prager, Rolf H.; Williams, Craig M.. Application of 50551-57-0 The article mentions the following:

Et 5-oxo-2-phenyl-2,5-dihydroisoxazole-4-carboxylate was photolyzed at 300 nm in the presence of phenols, enols, anilines, enamines, aryl thiols and thioenols affording enamines. Treatment of these enamines with Lewis or protic acids gives the resp. benzo and five-membered ring systems. After reading the article, we found that the author used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Application of 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Application of 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem