Category: benzofurans

Martin, R. published the artcileReinvestigation of the phenylpropanoids from the roots of Pimpinella species, Related Products of benzofurans, the main research area is phenylisopropanoid Pimpinella structure; isoeugenol derivative Pimpinella structure; fatty acid ester phenylisopropanoid Pimpinella; linolenate ester phenylisopropanoid Pimpinella.

The roots of P. saxifraga and P. major (Umbelliferae) were reexamined for their isoeugenol derivatives According to high field 1H and 13C NMR, as well as mass spectroscopic studies, the previously described substitution pattern (4-OH, 5-OMe) must be revised to be 2-OH and 5-OMe. A fatty acid ester of a phenylpropanoid was found, its structure was elucidated by 2-dimensional 1H NMR (1H-1H correlated spectroscopy).

Planta Medica published new progress about Pimpinella saxifraga. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Geng, Pengxin published the artcileA g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations, Name: 4-Chlorophthalide, the main research area is graphitic carbon nitrid heterogeneous photocatalytic benzylic oxygenation; green chem.

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biol. valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this “”green”” methodol. was further demonstrated by applying in bioactive and drug valued target syntheses.

Green Chemistry published new progress about C-H bond activation. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Name: 4-Chlorophthalide.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Anjie published the artcileMetal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols, Recommanded Product: 6-Methoxybenzofuran, the main research area is metal free oxidative carbon bond cleavage heteroaryl alc.

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Organic Letters published new progress about C-C bond cleavage. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-directed synthesis of moracin M, a phytoalexin of Morus alba Linn, Formula: C9H8O2, the main research area is moracin M; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran bromozincbenzofuran iodoresorcinol; iodoresorcinoltricarbonylchromium coupling halobenzofuran.

2-(5-Resorcinyl)benzofurans have been synthesized by the Pd-catalyzed cross-coupling of 2-trimethylstannyl- or 2-bromozincbenzofurans with functionalized 5-iodoresorcinols. These were synthesized by the triisopropylsilyloxy-directed remote (C-5) lithiation/iodination of the O,O-bis(triisopropylsilyl)resorcinoltricarbonylchrhomium(0) complex. The method was applied to the synthesis of moracin M (I).

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Formula: C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-mediated synthesis of some prenylated phytoalexins of Morus alba Linn, Category: benzofurans, the main research area is moracin prenylated; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran iodoresorcinol chromium carbonyl.

Directed functionalization of resorcinol and benzofuran rings was achieved by activation with a coordinated tricarbonylchromium(0) unit and vicinal or remote lithiation directed by methoxy or tert-butyldiphenylsilyloxy groups resp. The process was applied either before [to the geranylbenzofuran for mulberrofuran B (I, R = Me, R1 = geranyl, R2-R4 = H)] or after [for moracin C (I, R-R2 = H, R3 = prenyl, R4 = Me)] Pd-catalyzed coupling of the 2-stannylated benzofuran and the 5-iodinated resorcinol moieties. In addition moracin I (I, R, R1, R3 = H, R2 = prenyl, R4 = Me) was synthesized by a Stille coupling of the stannylated benzofuran with the phloroglucinol triflate. Application to the synthesis of albafuran A (I, R, R1, R3, R4 = H, R2 = geranyl) gave, unexpectedly, the 3-geranylbenzofuran II.

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Clough, John M. published the artcileTransition metal-mediated organic synthesis: synthesis of moracin M, Category: benzofurans, the main research area is halobenzofuran metalloresorcinol chromium carbonyl coupling; metallobenzofuran haloresorcinol chromium carbonyl coupling; coupling benzofuran resorcinol palladium catalyst; moracin M.

The Pd-catalyzed cross-coupling of 2-halo- or 2-metallobenzofurans with both 5-metallo- or 5-haloresorcinol tricarbonyl chromium(0) complexes or with the uncomplexed resorcinols, has been evaluated and in consequence, moracin M (I) has been synthesized in good yield by the cross-coupling of 6-(tert-butyldiphenylsiloxy)-2-trimethylstannylbenzofuran with 5-iodoresorcinol bis(triisopropylsilyl) ether and fluoride ion deprotection of the product.

Tetrahedron Letters published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yamaguchi, Yuki published the artcileSynthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6, HPLC of Formula: 50551-63-8, the main research area is benzofuran derivative preparation human microsomal cytochrome inhibitor; coumarin derivative preparation human microsomal cytochrome inhibitor; human microsomal cytochrome inhibitor reduce smoking tobacco cancer.

Human microsomal cytochrome P 450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. A series of benzofuran and coumarin derivatives having inhibitory effects on the activity of human CYP2A6 have been described. Synthesized benzofuran I [IC50 = 2.20 μM] and coumarin II [R= 5-methoxy: IC50 = 0.13μM , R=6-methoxy: IC50 = 0.64 μM] derivatives were found to be more selective than methoxalen and menthofuran. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.

Chemical & Pharmaceutical Bulletin published new progress about Coumarins Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Velasco-Negueruela, A. published the artcileAnalysis by gas chromatography-mass spectrometry of the essential oils from the aerial parts of Pimpinella anagodendron Bolle and Pimpinella rupicola Svent., two endemic species to the Canary Islands, Spain, Application of 5-Methoxy-2-methylbenzofuran, the main research area is terpene arylpropanoid essential oil Pimpinella GC MS.

The essential oils from the aerial parts of Pimpinella anagodendron Bolle and Pimpinella rupicola Svent., two endemic species growing in Tenerife, Canary Islands, Spain, were studied by gas chromatog. and gas chromatog.-mass spectrometry. The major components of the flowering tops (flowers + unripe fruits) of P. rupicola (PRFT) were found to be β-bisabolene (34.8%), limonene (10.9%) and α-zingiberene (10.5%), whereas in the flowering tops of P. anagodendron (PAFT), the main constituents were α-zingiberene (32.9%), β-bisabolene (17.9%), β-pinene (15.8%) and ar-curcumene (11.5%). The major compounds found in the stems + leaves of P. rupicola (PRSL) were β-bisabolene (31.6%), α-zingiberene (11.4%) and limonene (10.8%), whereas those of P. anagodendron (PASL) were α-zingiberene (32.3%), β-bisabolene (14.0%) and ar-curcumene (12.6%). In all the oils were found the characteristic constituents of genus Pimpinella, the pseudoisoeugenol esters. In accordance with the morphol., chorol. and chem. differences between both species, we suggest that P. rupicola Svent. is a good taxon and not a synonym of P. anagodendron.

Journal of Chromatography A published new progress about Gas chromatography-mass spectrometry. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Application of 5-Methoxy-2-methylbenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Velasco-Negueruela, A. published the artcileAnalysis by gas chromatography-mass spectrometry of the essential oil from the aerial parts of Pimpinella junoniae Ceb. & Ort., gathered in La Gomera, Canary Islands, Spain, Quality Control of 13391-27-0, the main research area is terpene arylpropanoid gas chromatog oil Pimpinella.

The essential oil from the aerial parts of Pimpinella junoniae Ceb.& Ort., growing in La Gomera, Canary Islands, Spain, was studied by gas chromatog. and gas chromatog.-mass spectrometry, and 43 constituents were identified. The major components were found to be α-zingiberene (20.6%), α-pinene (17.9%), (E)-β-farnesene (9.3%), ar-curcumene (7.4%), β-phellandrene (7.0%), β-bisabolene (6.1%) and epoxypseudoisoeugenyl 2-methylbutyrate (6.0%). The decomposition product of epoxypseudoisoeugenol derivatives, 5-methoxy-2-methylbenzofuran (5.7%), moderate amounts of other arylpropanoids with the pseudoisoeugenol skeleton (total percentage, 5.2%) and other compounds such as β-sesquiphellandrene (3.0%), cis-β-guaiene (1.5%), α-phellandrene (1.5%) and α-bisabolol (1.3%), were also found.

Journal of Chromatography A published new progress about Gas chromatography-mass spectrometry. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Quality Control of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Vargas, David A. published the artcileBiocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds, Quality Control of 50551-63-8, the main research area is diastereoselective enantioselective synthesis dihydrobenzofuran scaffold myoglobin engineering; benzofuran cyclopropanation; biocatalysis; carbene transfer; dihydrobenzofurans; myoglobin.

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive mols. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochem. rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochem. model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug mol. and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asym. C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

Angewandte Chemie, International Edition published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem