Category: 87-41-2

An article Oxidative Kinetic Resolution of Cyclic Benzylic Ethers WOS:000585986100001 published article about C-H BONDS; RACEMIC SECONDARY ALCOHOLS; HYDROGEN-PEROXIDE; ASYMMETRIC EPOXIDATION; OXOCARBENIUM IONS; AEROBIC OXIDATION; HYDROXYLATION; MECHANISM; COMPLEX; DESYMMETRIZATION in [Sun, Shutao; Ma, Yingang; Liu, Ziqiang; Liu, Lei] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Peoples R China; [Sun, Shutao; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China in 2021, Cited 69. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp(3))-H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the alpha position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 J AGR FOOD CHEM published article about LIQUID-CHROMATOGRAPHY; FUNGAL ENDOPHYTES; PLANT; DERIVATIVES; HOST in [Cui, Jin-Long; Gong, Yi; Wang, Meng-Liang; Wang, Jun -Hong; Xue, Xiao-Zan] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China; [Zhang, Gang] Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Shaanxi, Peoples R China; [Vijayakurnar, Vinod] Ohio State Univ, Dept Food Sci & Technol, Coll Food Agr & Environm Sci, Columbus, OH 43210 USA; [Gong, Yi; Xue, Xiao-Zan] Shanxi Univ, Inst Biotechnol, Taiyuan 030006, Shanxi, Peoples R China in 2019, Cited 42. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. SDS of cas: 87-41-2

Cynomorium songaricum Rupr. is a valuable food and medicinal plant with functions, such as an increase in sexual function, mainly attributed to its complex secondary metabolites. However, the effect of internal microbes on metabolite production in C. songaricum is still largely unclear. In this study, the relationship between endophytes and differential secondary metabolites in C. songaricum from seven major producing regions of China were explored based on established methods of metabolomics and high-throughput sequencing. The results showed that there were 13 different marker metabolites, seven shared fungal OTUs, and numerous unshared OTUs among C. songaricum distributed at different locations in China and identified significant correlations between metabolites and endophytic fungi. Our study revealed that endophytic fungi may be one possible factor that can affect the plant secondary metabolite composition.

Welcome to talk about 87-41-2, If you have any questions, you can contact Cui, JL; Gong, Y; Vijayakurnar, V; Zhang, G; Wang, ML; Wang, JH; Xue, XZ or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 published in 2019. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Pittayakhajonwut, P (corresponding author), Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P or send Email.

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Benzofuran – Wikipedia,
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Abbod, M; Safaie, N; Gholivand, K; Mehrabadi, M; Bonsaii, M in [Abbod, Mohsen; Safaie, Naser] Tarbiat Modares Univ, Fac Agr, Dept Plant Pathol, POB 14115-336, Tehran, Iran; [Gholivand, Khodayar; Bonsaii, Mahyar] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Mehrabadi, Mohammad] Tarbiat Modares Univ, Fac Agr, Dept Entomol, POB 14115-336, Tehran, Iran published Mode of action of 3-butylidene phthalide as a competent natural pesticide in 2020, Cited 64. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

In this study, the biological activities and mode of action of 3-butylidene phthalide (3-BPH) were studied. 3-BPH had a superior efficiency against microsclerotia of Macrophomina phaseolina compared to the commercial fungicide tricyclazole. The microsclerotia formation and pigmentation were inhibited at 100 mu g/mL. Moreover, the fungicide exhibited in silico affinity toward trihydroxy naphthalene reductase (3HNR). Both 3-BPH and tricyclazole showed congruence in the orientation and interaction within the 3HNR active site. 3-BPH displayed a strong interaction with SER-164, TYR-178, and TYR-223, with estimated binding energy and inhibition constant of -6.78 kcal mol(-1), and Ki = 12.6 mu M, respectively. Furthermore, it showed in vitro and in silico inhibitory activity against Drosophila melanogaster acetylcholinesterase in a concentration-dependent manner with IC50 = 730 mu g/mL. It also impaired Galleria mellonella phenol oxidase enzyme, which corresponds with the insect’s immune system. Phytotoxicity of 3-BPH was evident against Lemna minor at 1000 mu g/mL; nevertheless, it was nontoxic at the concentrations inhibiting M. phaseolina microsclerotia and dark pigments suggest that it may be safe for use on other plants at low doses. Further assays are wanted to develop 3-BPH as a novel crop protection compound.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. In 2019 CHEM COMMUN published article about DIMERS in [Zou, Jian; Chen, Guo-Dong; Wang, Xiao-Xia; He, Rong-Rong; Yao, Xin-Sheng; Gao, Hao] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdon Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China; [Zou, Jian] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China; [Zhao, Huan] Jinan Univ, Coll Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China; [Zhang, Zai-Jun; So, Kwok-Fai] Jinan Univ, Inst New Drug Res, Coll Pharm, Guangzhou Key Lab Innovat Chem Drug Res Cardiocer, Guangzhou 510632, Guangdong, Peoples R China; [Qu, Yi-Bo] Jinan Univ, GMH Inst Cent Nervous Syst Regenerat, Guangdong Med Key Lab Brain Funct & Dis, Guangzhou 510632, Guangdong, Peoples R China in 2019, Cited 18. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Triangeliphthalides A-D (1-4), four novel phthalide trimers with two new linkage styles, were isolated from Angelica sinensis, together with two related phthalide dimers (5-6). Their structures including absolute configurations were determined. The production mechanism of phthalide polymers was proposed, and their bioactivities were also evaluated.

Welcome to talk about 87-41-2, If you have any questions, you can contact Zou, J; Chen, GD; Zhao, H; Wang, XX; Zhang, ZJ; Qu, YB; He, RR; So, KF; Yao, XS; Gao, H or send Email.. Category: benzofurans

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about RADICAL REACTIONS; INTERMEDIATE; PHOTOLYSIS; CHEMISTRY, Saw an article supported by the Hellenic Foundation for Research and Innovation (HFRI); General Secretariat for Research and Technology (GSRT), under the HFRI PhD Fellowship grant [4813]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Tzirakis, MD; Malliaros, NG; Orfanopoulos, M. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Safety of Isobenzofuran-1(3H)-one

A new, simple, and rapid photochemical reaction of o-phthalaldehyde with C-60 has been disclosed. This reaction afforded exclusively the unanticipated C-60-phthalide derivative 11 in good yield. The formation of this product is consistent with the intervention of a key free-radical intermediate -a benzylic radical- in the course of the reaction. The structure of 11 has been determined by the combined use of experimental and theoretical NMR studies. In the course of this study we further disclosed a new mode of radical reactivity of C-60 with a series of substituted phthalides (2, 15-17) catalyzed by tetrabutylammonium decatungstate.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about TRADITIONAL CHINESE MEDICINE; CORONARY-HEART-DISEASE; UP-REGULATION; ATHEROGENESIS; CHOLESTEROL; ACTIVATION; MACROPHAGE in [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Ni, Jia-Nan] Tianjing Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China in 2019, Cited 36. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

Welcome to talk about 87-41-2, If you have any questions, you can contact Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G or send Email.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Recently I am researching about FRIEDEL-CRAFTS ALKYLATION; CYCLIZATION; HALIDES; ARENES; ACID; NUCLEOPHILES; ALCOHOLS; BROMIDES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21703061]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Lv, F; Xiao, J; Xiang, JC; Guo, FZ; Tang, ZL; Han, LB. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I-2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about C-H BONDS; CATALYZED AEROBIC OXIDATION; ELECTRON-TRANSFER REACTIONS; LIGHT PHOTOREDOX CATALYSIS; VISIBLE-LIGHT; SINGLET OXYGEN; METAL-FREE; MOLECULAR-OXYGEN; PHOTOCATALYTIC OXIDATION; KIKUCHII MATSUMOTO, Saw an article supported by the National Key R&D Program of China [2018YFA0901700]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21703036]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20160167]; Thousand Talents Plan (Young Professionals); Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [JUSRP51712B]; Postdoctoral Foundation in Jiangsu Province [2018K153C]; National First-class Discipline Program of Light Industry Technology and Engineering [LITE2018-14]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, J; Bao, WH; Tang, ZC; Guo, BD; Zhang, SW; Liu, HL; Huang, SP; Zhang, Y; Rao, YJ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Quality Control of Isobenzofuran-1(3H)-one

The development of an efficient system for selective oxidation of organic compounds to generate more valuable compounds with molecular oxygen is a significant challenge in industrial chemistry. Bioinspired by the ability of naturally occurring perylenequinonoid pigments (PQPs) to generate reactive oxygen species (ROS) upon photoirradiation, here we report that cercosporin, one of the perylenequinonoid pigments, can function as a cost-effective and environmentally friendly photocatalyst for a wide range of selective oxidations, including benzylic C-H bonds to carbonyls, amines to aldehydes, and sulfides to sulfoxides. All of the representative reactions proceeded smoothly with high efficiency under mild conditions. Owing to the use of inexpensive metal-free visible light-driven photocatalyst produced from microbial fermentation with cheap glucose as the starting material and the ease of handling, we expect that this developed method will be particularly attractive for many more applications in synthetic transformation.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Aldehyde effect and ligand discovery in Ru-catalyzed dehydrogenative cross-coupling of alcohols to esters WOS:000460683700012 published article about ACCEPTORLESS DEHYDROGENATION; ALIPHATIC-ALCOHOLS; COMPLEXES; OXIDATION; ESTERIFICATION in [Jiang, Xiaolin; Zhao, Dongmei] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China; [Jiang, Xiaolin; Zhang, Jiahui; Li, Yuehui] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Suzhou Res Inst LICP, Lanzhou 730000, Peoples R China; [Zhang, Jiahui] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

The presence of different aldehydes is found to have a significant influence on the catalytic performance when using PN(H)P type ligands for dehydrogenation of alcohols. Accordingly, hybrid multi-dentate ligands were discovered based on an oxygen-transfer alkylation of PNP ligands by aldehydes. The relevant Ru-PNN(PO) system provided the desired unsymmetrical esters in good yields via acceptorless dehydrogenation of alcohols. Hydrogen bonding interactions between the phosphine oxide moieties and alcohol substrates likely assisted the observed high chemoselectivity.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem